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AI-Enhanced Technology Predicts Fatal and Non-Fatal Cardiac Events from Routine CCTA
By MedImaging International staff writers Posted on 20 Nov 2023
Image: The CaRi-Heart Analysis imaging solution applies AI to standard CCTA images (Photo courtesy of Caristo Diagnostics)
Annually, over 8 million people in the United States seek emergency medical attention due to chest pain. Typically, these patients undergo coronary computed tomography angiography (CCTA) to check for coronary artery disease (CAD), which is caused by the narrowing or obstruction of the arteries supplying blood to the heart. However, significant narrowing is not always detected during CCTA in many of these cases. Despite this, a considerable number of these individuals suffer fatal heart attacks in subsequent years due to minor, yet inflamed plaques that burst. Now, an innovative artificial intelligence (AI) technology has been developed that can predict both fatal and non-fatal cardiac events. This prediction is independent of standard clinical risk assessments and CCTA results, and it has the potential to revolutionize the way CAD is treated by transforming the risk evaluation and management of patients who undergo routine CCTA.
The CaRi-Heart technology from Caristo Diagnostics (Oxford, UK) is an AI-powered imaging tool that assesses coronary inflammation and characterizes plaque, aiding clinicians in better decision-making for patient care. This cloud-based software as a service (SaaS) medical device utilizes AI to process standard CCTA images. It introduces a unique imaging biomarker, the Fat Attenuation Index (FAI), to measure the extent of coronary inflammation and provides detailed analysis of plaque characteristics that are often linked with heart attacks.
The ORFAN study, the largest of its kind aimed at evaluating the effectiveness of CT imaging biomarkers in predicting long-term cardiovascular outcomes, demonstrated that coronary inflammation measured by Caristo's CaRi-Heart FAI-Score could foresee fatal and non-fatal cardiac events. These predictions were made independently of routine risk factors and standard CCTA interpretations. In this study, CaRi-Heart Risk functioned as the "AI-Risk" model, which reclassified about 30% of patients into higher risk categories and around 10% into lower risk categories. When these results were reviewed by clinicians, it led to changes in patient management in nearly half of the cases, primarily targeting previously unrecognized coronary inflammation.
"We are excited to see these exceptional clinical results enabled by our CaRi-Heart technology," said Frank Cheng, CEO of Caristo Diagnostics. "To eradicate heart disease as the number one cause of death globally, it is important for us to realize that people may have heart attack soon after a 'normal' CCTA test showing zero calcium score, no plaque, and no stenosis. The CaRi-Heart technology has the potential to save millions of lives worldwide by improving risk stratification based on CCTA-based coronary inflammation measurement. We look forward to introducing our technology across geographies to transform cardiac care and make heart attacks a preventable reality worldwide."
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(30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799342 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 189
(33.140182495117): SELECT id,name,title
FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
AND id != 294743300
AND id != 294743301
AND id != 294743302
AND id != 294743303
AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`90
(46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 191
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 192
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 193
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 194
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 195
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 196
(33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 197
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 198
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 199
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1105
(42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1106
(77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1107
(72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1108
(96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1109
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1110
(53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(467.06199645996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1112
(554.08477783203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1113
(321.1498260498): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1114
(75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1115
(56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1116
(65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1117
(39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1118
(92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1119
(39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1120
(272.98927307129): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`121
(!!!!! 29363.870620728): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7122
(199.0795135498): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1123
(92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1124
(437.02125549316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799342 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799342 AND type='deeppockets_item' AND published='1' LIMIT 1125
(!!!!! 570088.14811707): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3126
(98.943710327148): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3127
(66.995620727539): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1128
(39.815902709961): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1129
(66.995620727539): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1130
(36.954879760742): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1131
(36.954879760742): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1132
(32.901763916016): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1133
(491.85752868652): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294799342
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1134
(335.9317779541): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294799342
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1135
(38.14697265625): SELECT name FROM jos_deeppockets WHERE id=215136
(29.087066650391): SELECT name FROM jos_deeppockets WHERE id=215137
(442.9817199707): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3138
(350.9521484375): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3139
(58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1140
(47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1141
(!!!!! 9318.1133270264): TRUNCATE TABLE jos_trademed_module142
(92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1143
(54.836273193359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294799342
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1144
(822.06726074219): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294799342
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1145
(54.121017456055): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294799342
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1146
(52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1147
(38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1148
(!!!!! 1034.0213775635): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6149
(77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1150
(58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1151
(37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294799342 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294799342 AND type='deeppockets_item' AND published='1' LIMIT 1152
(30.994415283203): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)153
(26.941299438477): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)154
(28.133392333984): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1155
(103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1156
(46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294799342 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294799342 AND published='1'
LIMIT 1157
(37.908554077148): select jos_twitters.link from jos_twitters where cat=10158
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10159
(30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10160
(30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10161
(275.1350402832): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)162
(!!!!! 1252.1743774414): insert into jos_banners_delta values (14615,'2025-05-01 23:44:48','13.58.115.236','view'),(14202,'2025-05-01 23:44:48','13.58.115.236','view'),(14203,'2025-05-01 23:44:48','13.58.115.236','view')
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