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Tau PET Scans Superior at Predicting Cognitive Decline in Patients than Commonly Used Imaging Techniques
By MedImaging International staff writers Posted on 10 Aug 2023
Image: Tau imaging with 18F-Flortaucipir PET in Alzheimer’s disease (Photo courtesy of UNIGE)
Alzheimer's disease, a common neurodegenerative disorder, results in a gradual deterioration of memory and autonomy. This condition is characterized by the buildup of neurotoxic proteins, specifically amyloid plaques and tau tangles, within the brain. Given the silent progression of these pathological changes over decades, early diagnosis is vital to initiate interventions as soon as feasible in the disease's course. Now, researchers have demonstrated that tau PET, an innovative imaging method for visualizing the tau protein, can predict cognitive decline in patients with superior accuracy compared to conventional imaging techniques. These findings support the rapid integration of tau PET into clinical practice for providing early and individualized interventions for patients.
Positron emission tomography (PET), a key diagnostic tool for Alzheimer's disease, employs injected tracers to visualize specific brain pathologies. While amyloid plaques may not invariably correlate with cognitive or memory impairment, the presence of tau aligns closely with clinical symptoms and significantly influences whether a patient remains stable or deteriorates rapidly. Visualizing tau using imaging techniques has posed challenges due to its intricate structure and lower concentration. Flortaucipir, a radiotracer approved by the U.S. Food and Drug Administration (FDA) in 2020, binds with the tau protein. This tracer facilitates the detection of tau accumulation and its spatial distribution in the brain, enabling precise evaluation of its role in the clinical manifestation of the disease.
Scientists from the University of Geneva (UNIGE, Geneva, Switzerland) and the Geneva University Hospitals (HUG, Geneva, Switzerland) embarked on a study to determine which imaging technique—amyloid PET, glucose metabolism PET, or tau PET—best predicted future cognitive decline in Alzheimer's disease. The study enrolled around 90 participants from the HUG Memory Centre. The study revealed that while all PET measures correlated with the presence of cognitive symptoms, validating their role as strong indicators of Alzheimer's disease, tau PET exhibited the greatest predictive capacity for cognitive decline rates, even in individuals with minimal symptoms. These findings support incorporating tau PET into routine clinical assessments to assess individual prognosis and select the most appropriate therapeutic plan for each patient.
“This breakthrough is crucial for better management of Alzheimer’s disease. Recently, drugs targeting amyloid have shown positive results. New drugs targeting the tau protein also look promising,” said Associate Professor Valentina Garibotto who directed the research. “By detecting the pathology as early as possible, before the brain is further damaged, and thanks to new treatments, we hope to be able to make a greater impact on patients’ future and quality of life. Similarly, we are beginning to map the distribution of tau in order to understand how its location in the different regions of the brain influences symptoms.”
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(152.1110534668): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798227 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 189
(35.04753112793): SELECT id,name,title
FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
AND id != 294743300
AND id != 294743301
AND id != 294743302
AND id != 294743303
AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`90
(50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 191
(30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 192
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 193
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 194
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 195
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 196
(32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 197
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 198
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 199
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1105
(43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1106
(50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1107
(46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1108
(81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1109
(45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1110
(46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(516.89147949219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1112
(517.12989807129): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1113
(347.85270690918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1114
(73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1115
(44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1116
(79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1117
(38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1118
(98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1119
(40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1120
(260.1146697998): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`121
(!!!!! 18314.838409424): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7122
(121.8318939209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1123
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1124
(452.99530029297): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798227 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798227 AND type='deeppockets_item' AND published='1' LIMIT 1125
(!!!!! 394112.82539368): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3126
(82.969665527344): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3127
(36.954879760742): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1128
(30.040740966797): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1129
(39.815902709961): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1130
(29.087066650391): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1131
(40.054321289062): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1132
(30.040740966797): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1133
(455.85632324219): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294798227
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1134
(437.02125549316): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294798227
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1135
(40.054321289062): SELECT name FROM jos_deeppockets WHERE id=215136
(30.040740966797): SELECT name FROM jos_deeppockets WHERE id=215137
(492.09594726562): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3138
(352.14424133301): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3139
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1140
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1141
(!!!!! 14547.824859619): TRUNCATE TABLE jos_trademed_module142
(91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1143
(54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294798227
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1144
(437.97492980957): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294798227
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1145
(53.167343139648): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294798227
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1146
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1147
(45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1148
(!!!!! 1147.0317840576): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6149
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1150
(41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1151
(57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294798227 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294798227 AND type='deeppockets_item' AND published='1' LIMIT 1152
(43.869018554688): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)153
(42.915344238281): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)154
(35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1155
(86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1156
(51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294798227 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294798227 AND published='1'
LIMIT 1157
(48.160552978516): select jos_twitters.link from jos_twitters where cat=10158
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10159
(30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10160
(30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10161
(287.05596923828): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)162
(!!!!! 1236.2003326416): insert into jos_banners_delta values (14615,'2025-05-17 11:50:40','3.147.79.68','view'),(14202,'2025-05-17 11:50:40','3.147.79.68','view'),(14203,'2025-05-17 11:50:40','3.147.79.68','view')
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