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Photon-Counting CT Allows for Comprehensive Lung Imaging
By MedImaging International staff writers Posted on 18 Jul 2023
Image: Photon-counting CT can evaluate lung function (Photo courtesy of Freepik)
Chest CT scans are the preferred imaging method for analyzing lung disease and monitoring its progression. However, CT studies assessing lung function and blood flow require specific protocols that cannot be integrated. Now, a study has discovered that a new CT technology facilitates a comprehensive, simultaneous analysis of lung structure and function, an achievement beyond the capabilities of standard CT.
Researchers at Hannover Medical School (Hannover, Germany) have developed a chest imaging protocol that provides information about the structure and function of the lungs. This protocol employs the recently introduced photon-counting CT technology, which allows for high-quality images at a radiation dose lower than that of a standard chest CT. It also delivers improved spatial resolution and spectral imaging capabilities, which leverage the energy information from X-rays to determine tissue composition. The novel protocol requires advanced software, but no additional hardware. It was tested on 197 patients with varying known and unknown lung function impairments who had clinically indicated CT scans. After an intravenous contrast agent was administered, a photon-counting CT scan was conducted during inhalation, followed by another scan during exhalation. All CT-derived parameters were acquired successfully in 166 patients, reflecting an 85% success rate.
The protocol enabled simultaneous assessment of lung structure, ventilation, vasculature, and perfusion of the parenchyma, the region containing gas-exchanging alveoli, the tiny air sacs involved in the exchange of oxygen and carbon dioxide during respiration. This protocol demonstrated benefits over standard CT. The photon-counting CT protocol has the potential for further applications in lung imaging. It can be crucial for preoperative identification of emphysema areas and perfusion defects in patients with chronic thromboembolic pulmonary hypertension, a progressive disease caused by unresolved blood clots in the lungs. Postoperatively, it facilitated the evaluation of surgical success and was useful in assessing the lungs after lung or stem cell transplant procedures. It may also be valuable in the follow-up of chronic obstructive pulmonary disease and in examining pathological findings in lung tissue. Currently, the researchers are focused on enhancing processing time and bolstering the technique's robustness.
"The improvement in the contrast-to-noise ratio and spatial resolution of the pulmonary blood volume images was substantial," said study senior author Hoen-oh Shin, M.D., professor of radiology at the Institute of Diagnostic and Interventional Radiology at Hannover Medical School. "In my opinion, the most important advantage is the significantly improved spectral resolution, which enables new applications such as functional imaging of the lungs with CT."
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(96.797943115234): SELECT id,name,title
FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
AND id != 294743300
AND id != 294743301
AND id != 294743302
AND id != 294743303
AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`90
(46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 191
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 192
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 193
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 194
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 195
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 196
(32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 197
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 198
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 199
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1105
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1106
(50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1107
(49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1108
(76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1109
(43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1110
(51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(572.91984558105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1112
(730.99136352539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1113
(627.99453735352): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1114
(126.12342834473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1115
(133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1116
(82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1117
(59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1118
(79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1119
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1120
(457.0484161377): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`121
(!!!!! 23967.981338501): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7122
(99.18212890625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1123
(47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1124
(452.99530029297): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797922 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797922 AND type='deeppockets_item' AND published='1' LIMIT 1125
(!!!!! 451572.89505005): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3126
(99.18212890625): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3127
(49.114227294922): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1128
(39.815902709961): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800513
LIMIT 1129
(46.968460083008): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1130
(37.193298339844): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800359
LIMIT 1131
(36.954879760742): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1132
(34.093856811523): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294800361
LIMIT 1133
(602.96058654785): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294797922
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1134
(469.92301940918): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294797922
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1135
(46.014785766602): SELECT name FROM jos_deeppockets WHERE id=215136
(35.04753112793): SELECT name FROM jos_deeppockets WHERE id=215137
(601.05323791504): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3138
(520.94459533691): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3139
(78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1140
(69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1141
(!!!!! 9988.0695343018): TRUNCATE TABLE jos_trademed_module142
(138.99803161621): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1143
(73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294797922
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1144
(838.04130554199): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294797922
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1145
(73.909759521484): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294797922
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1146
(71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1147
(59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1148
(!!!!! 1528.0246734619): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6149
(72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1150
(64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1151
(51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797922 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797922 AND type='deeppockets_item' AND published='1' LIMIT 1152
(41.961669921875): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)153
(41.961669921875): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)154
(43.869018554688): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1155
(84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1156
(64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797922 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797922 AND published='1'
LIMIT 1157
(85.115432739258): select jos_twitters.link from jos_twitters where cat=10158
(36.954879760742): select jos_facebook.link from jos_facebook where cat=10159
(51.975250244141): select jos_google_plus.link from jos_google_plus where cat=10160
(40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10161
(323.05717468262): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)162
(!!!!! 1482.0098876953): insert into jos_banners_delta values (14615,'2025-05-08 14:27:56','3.15.164.223','view'),(14202,'2025-05-08 14:27:56','3.15.164.223','view'),(14203,'2025-05-08 14:27:56','3.15.164.223','view')
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