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Low-Dose Molecular Breast Imaging (MBI) Could Improve Cancer Detection in Dense Breast Tissue

By MedImaging International staff writers
Posted on 02 Feb 2023

Image: CZT gamma detector for SPECT imaging (Photo courtesy of Kromek)

Traditional mammography is often less able to clearly image tumors due to the density of the breast tissue. Molecular breast imaging (MBI) technology uses a radioactive tracer that ‘lights up’ areas of cancer in the breast and is effective even in dense breast tissue – which is prevalent in people who are at higher risk of cancer. However, MBI currently involves a much greater exposure to radiation than mammograms. Now, two research programs will aim to further develop low-dose MBI technology based on cadmium zinc telluride CZT-based SPECT (single-photon emission computed tomography) detector technology.

CZT is transforming gamma detectors used in medical imaging, leading to better diagnosis, faster treatment and lower costs for hospitals. The change from conventional scintillator technology to CZT is similar to upgrading from a black-and-white vacuum-tube television to a color digital high-definition flat-screen TV. Kromek (Sedgefield UK), which is at the forefront of CZT detector development, provides a way for medical device manufacturers to be part of this transformation sooner, integrate CZT gamma detectors into their SPECT systems, and bring new products to market cost-effectively. Kromek’s CZT-based SPECT detector technology uses low-dose MBI – to provide effective cancer detection with lower radiation exposure. CZT creates much clearer images and requires far lower radiation doses to do so, than comparable detectors, enabling the solution to deliver eight times less radiation than existing MBI technology. Kromek has now been awarded funding from the UK’s innovation agency, Innovate UK, for two research programs to further develop a low-dose MBI technology based on the company’s CZT-based SPECT detectors.

“Current routine breast screening does not meet everyone’s needs because of its shortcomings in detecting cancers in dense breast tissue, a particular concern for younger women. Low-dose molecular breast imaging, which solves this, has the capacity to save thousands more lives, detecting cancers earlier, before they have time to spread,” said Arnab Basu, CEO of Kromek Group. “This helps not only the patient, but also the public health authorities who can provide the right treatment earlier and, ultimately, more cost effectively. This additional funding from Innovate UK will allow us and our partners to collate the data needed to progress to clinical tests and then deployment. We look forward to working with our partners to complete the program.”

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70 (200.03318786621): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (200.98686218262): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (573.87351989746): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (375.98609924316): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (252.96211242676): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (108.95729064941): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (564.0983581543): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (216.96090698242): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (425.81558227539): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (175.95291137695): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (574.11193847656): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (565.0520324707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

105 (797.98698425293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

106 (480.89027404785): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1430.0346374512): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

109 (749.11117553711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

110 (355.00526428223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (707.86476135254): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (626.0871887207): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (381.9465637207): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

115 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

116 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

117 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

120 (262.97569274902): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 73002.099990845): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (177.14500427246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

123 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

124 (!!!!! 1235.0082397461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294796139 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294796139 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 836843.01376343): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 690794.94476318): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (93.936920166016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (534.0576171875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (331.87866210938): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (194.07272338867): SELECT name FROM jos_deeppockets WHERE id=215

136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=215

137 (582.93342590332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (500.91743469238): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

140 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

141 (!!!!! 9517.9080963135): TRUNCATE TABLE jos_trademed_module

142 (117.06352233887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294796139 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (447.03483581543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

147 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

148 (!!!!! 1416.9216156006): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

150 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

151 (64.13459777832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294796139 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294796139 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (92.983245849609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (126.12342834473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

156 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294796139 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294796139 AND published='1' LIMIT 1

157 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10

158 (36.001205444336): select jos_facebook.link from jos_facebook where cat=10

159 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

160 (33.855438232422): select jos_linkedin.link from jos_linkedin where cat=10

161 (347.85270690918): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 3348.1121063232): insert into jos_banners_delta values (14615,'2025-04-30 18:53:41','3.23.102.52','view'),(14202,'2025-04-30 18:53:41','3.23.102.52','view'),(14203,'2025-04-30 18:53:41','3.23.102.52','view')

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