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Artificial Intelligence Technology Produces CT Images Based on MRI Without Exposure to Radiation

By MedImaging International staff writers
Posted on 11 Nov 2021

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Researchers have developed an artificial intelligence (AI) technology to generate CT images based on MRI images without exposure to radiation.

The results of a simulation experiment conducted by researchers at the Korea Institute of Science and Technology (KIST; Seoul, South Korea) have shown that the transcranial focused ultrasound procedure could be performed with MRI alone. Transcranial focused ultrasound can be used to treat degenerative movement disorders, intractable pain, and mental disorders by delivering ultrasound energy to a specific area of the brain without opening the skull. This treatment must be performed with an image-based technology that can locate the brain lesions.

Doctors typically use CT to obtain information about a patient's skull that is difficult to identify with MRI alone and to accurately focus the ultrasound on the lesions through the skull. However, there have been concerns about the safety of CT scans, during which radiation exposure is inevitable, especially in pediatric and pregnant patients. Efforts have been made to obtain cranial information from MRI images, but special coils for the MRI or imaging protocols that are not widely available in the medical field are required. As an alternative, interest for acquiring AI-based CT images has been high worldwide, but their clinical efficacy has not been proven.

The KIST research team proved that CT images obtained by AI have clinical utility. The researchers developed a three-dimensional conditional adversarial generative network that learns the nonlinear CT transformation process from T1-weighted MRI images, which is one of the most commonly used images in the medical field. The team devised a loss function that minimizes the Hounsfield unit pixel variation error of the CT images, and also optimized the neural network performance by comparing the changes in quality of the synthetic CT images according to the normalization methods of MRI image signals, such as Z-score normalization and partial linear histogram matching normalization.

For safe and effective ultrasound treatment, it is imperative to understand each patient's skull density ratio and skull thickness in advance, and when these skull factors were obtained via the synthetic CT, both factors showed >0.90 correlation with the actual CT. There was no statistically significant difference. Moreover, when simulated ultrasound treatment was performed, the ultrasound focal distance had an error of less than 1 mm, the intracranial peak acoustic pressure had an error of approximately 3.1%, and the focal volume similarity was approximately 83%. This demonstrated that the transcranial focused ultrasound treatment system can be performed with only the MRI image.

"Patients can receive focused ultrasound treatment without being worried about radiation exposure, and as the additional imaging and alignment processes can be omitted, this will reduce the staff's workload, leading to a reduction in time and economic costs," said Dr. Hyungmin Kim at KIST’s Bionics Research Center. "Through follow-up studies on identifying the error associated with the ultrasound parameters and transducers and understanding the possibility of artificial intelligence CT application in various parts of the body, we plan to continue developing the technology for its applicability in various treatment technologies."

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69 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (232.21969604492): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (217.91458129883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (34.809112548828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (34.093856811523): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

105 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

106 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

109 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

110 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (406.02684020996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (589.84756469727): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (321.86508178711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

115 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

116 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

117 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

118 (138.0443572998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

119 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

120 (238.89541625977): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 17976.999282837): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

123 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

124 (476.83715820312): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790472 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790472 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 422148.94294739): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (77.962875366211): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1456.0222625732): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (200.98686218262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (129.22286987305): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (329.97131347656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (238.89541625977): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (112.05673217773): SELECT name FROM jos_deeppockets WHERE id=215

136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=215

137 (423.19297790527): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (331.16340637207): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

140 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

141 (!!!!! 8341.0739898682): TRUNCATE TABLE jos_trademed_module

142 (176.90658569336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (99.897384643555): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790472 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 1108.1695556641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

147 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

148 (!!!!! 1488.9240264893): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (132.08389282227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

150 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

151 (67.949295043945): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790472 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790472 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (49.829483032227): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (75.817108154297): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (168.0850982666): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

156 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790472 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790472 AND published='1' LIMIT 1

157 (141.14379882812): select jos_twitters.link from jos_twitters where cat=10

158 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

159 (38.14697265625): select jos_google_plus.link from jos_google_plus where cat=10

160 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

161 (349.04479980469): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1399.9938964844): insert into jos_banners_delta values (14615,'2025-05-01 19:48:12','18.219.40.177','view'),(14202,'2025-05-01 19:48:12','18.219.40.177','view'),(14203,'2025-05-01 19:48:12','18.219.40.177','view')

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