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AI Chest CT Analysis Distinguishes COVID-19 from Pneumonia

By MedImaging International staff writers
Posted on 31 Mar 2020

$Image: Heatmaps of COVID-19 activation regions (Photo courtesy of Wuhan Huangpi People\'s Hospital)$

Image: Heatmaps of COVID-19 activation regions (Photo courtesy of Wuhan Huangpi People\'s Hospital)

An artificial intelligence (AI) deep learning model can accurately detect COVID-19 and differentiate it from community acquired pneumonia (CAP) and other lung diseases, according to a new study.

Researchers at Wuhan Huangpi People's Hospital (China), Shenzhen University Health Science Center (Shenzhen, China), and other institutions conducted a multicenter, retrospective study to develop the COVID-19 detection neural network (COVNet), a fully automatic AI framework that extracts visual features from volumetric chest CT exams for the detection of COVID-19, and differentiates them from CAP and other lung findings. Datasets were collected from six hospitals and diagnostic performance was assessed and evaluated.

In all, the collected dataset consisted of 4,356 volumetric chest CT exams from 3,322 patients (average age 49 years, 55% male). Overall per-exam sensitivity and specificity for detecting COVID-19 in the independent test set was 90% and 96%, respectively. The researchers also showed that the per-exam sensitivity and specificity for detecting CAP was 87% and 92%, respectively. The study was published on March 19, 2020, in Radiology.

“We were able to collect a large number of CT exams from multiple hospitals, which included 1,296 COVID-19 CT exams,” concluded lead author Lin Li, MD, of the Wuhan Huangpi People's Hospital department of radiology. “More importantly, 1,735 CAP and 1,325 non-pneumonia CT exams were also collected as the control groups in this study in order to ensure the detection robustness, considering that certain similar imaging features may be observed in COVID-19 and other types of lung diseases.”

The coronavirus Disease 2019 (COVID-19) outbreak has rapidly spread all over the world. On January 30, 2020, it was declared as a public health emergency of international concern by the World Health Organization (WHO). It is typically confirmed by reverse-transcription polymerase chain reaction (PCR), but CT can detect certain characteristic manifestations in the lung associated with COVID-19, such as bilateral ground-glass, consolidative pulmonary opacities on CT, and a crazy-paving pattern, among others.

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66 (314.95094299316): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

67 (48.160552978516): select jos_twitters.link from jos_twitters where cat=10

68 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

69 (34.809112548828): select jos_google_plus.link from jos_google_plus where cat=10

70 (32.186508178711): select jos_linkedin.link from jos_linkedin where cat=10

71 (33.855438232422): SELECT fid FROM jos_deeppockets WHERE id=294781425 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294781425 AND published='1' LIMIT 1

72 (33.140182495117): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

73 (271.79718017578): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (216.96090698242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

76 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (42.915344238281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

93 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

108 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

109 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (43.153762817383): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

112 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

113 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (530.00450134277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (640.869140625): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (415.08674621582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (141.85905456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

118 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

119 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

120 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

121 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

122 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

123 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

124 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

125 (401.02005004883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

126 (!!!!! 20747.184753418): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

127 (590.08598327637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781425 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781425 AND type='deeppockets_item' AND published='1' LIMIT 1

128 (!!!!! 8808.1359863281): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (111.81831359863): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (59.843063354492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (371.93298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (549.0779876709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (406.02684020996): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (267.98248291016): SELECT name FROM jos_deeppockets WHERE id=215

141 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=215

142 (593.90068054199): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (581.97975158691): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

145 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

146 (!!!!! 16110.897064209): TRUNCATE TABLE jos_trademed_module

147 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294781425 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (!!!!! 1040.9355163574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

152 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

153 (!!!!! 1425.02784729): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

154 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

155 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

156 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294781425 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294781425 AND type='deeppockets_item' AND published='1' LIMIT 1

157 (42.200088500977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

158 (38.862228393555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

159 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

160 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

161 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294781425 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294781425 AND published='1' LIMIT 1

162 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

163 (34.809112548828): select jos_facebook.link from jos_facebook where cat=10

164 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

165 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

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