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Hybrid Nanomaterial Platform Effectively Kills Cancer Cells

By MedImaging International staff writers
Posted on 27 Aug 2018
Print article
Image: A new study claims magnetite-gold hybrid nanomaterials advance theranostic therapies (Photo courtesy of NUST-MISiS).
Image: A new study claims magnetite-gold hybrid nanomaterials advance theranostic therapies (Photo courtesy of NUST-MISiS).
A magnetite-gold particle hybrid nanomaterial could serve as a universal platform to both detect cancer cells and target drug delivery to kill them, claims a new study.

Developed at the Russian National University of Science and Technology (NUST-MISiS; Moscow, Russia), the University of Duisburg-Essen (Germany), and other institutions, the hybrid nanomaterial is the result of successful epitaxial growth of 25 nm octahedral-shaped magnetite (Fe3O4) nanocrystals on 9 nm gold (Au) seed nanoparticles, using a modified wet-chemical synthesis. The nanoparticles exhibit bulk-like magnetic properties and an octahedral spatial morphology resembling a so-called “nanodumbbell” that is capable of carrying almost any drug to a tumor cell.

The nanoparticles can thus provide two functional surfaces. For instance, they could be conjugated with two fluorescent dyes, or a combination of drug and dye, thus allowing for simultaneous tracking of the nanoparticle vehicle and the drug cargo both in-vitro and in-vivo. For the study, the researchers verified delivery to tumors and payload release in real time using intravital microscopy. Replacing the dyes with cell-specific molecules and drugs could make the Fe3O4-Au hybrids a unique platform for theranostics, claim the researchers.

For example, if the pathogenic cells are tagged with magnetic nanoparticles, they can be diagnosed with the help of magnetic resonance imaging (MRI) and subsequently destroyed using either a chemotherapy drug or via a strong magnetic field that could heats and kills cancer cells. Preliminary laboratory tests in mice with grafted tumors have already been completed, and the most optimistic researchers on the project say it will be possible to proceed to pre-clinical trials in just two to three years. The study was published on July 26, 2018, in Nature Scientific Reports.

“Hybrid materials for theranostics are increasingly attracting attention since they enable the combination of different properties and functions in one multipurpose hybrid material. In particular, high adaptability is achieved by controlling the surface chemistry,” concluded lead author Mariya Efremova, PhD, of NUST-MISiS, and colleagues. “Due to biocompatibility, Fe3O4 and Au are the materials of choice for therapeutic and diagnostic dual use. Such NPs represent a unique platform for modern theranostics, comprising the diagnostics function together with the ability for studying the cargo and vehicle functions separately and in conjugation.”

Theranostics uses specific biological pathways to acquire diagnostic images and deliver a therapeutic dose of radiation. Once a specific diagnostic test shows a particular molecular target on a tumor, the therapy agent can be specifically targeted to that receptor, providing a more targeted and efficient form of pharmacotherapy.

Related Links:
Russian National University of Science and Technology
University of Duisburg-Essen
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				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
49
(68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
50
(386.95335388184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
51
(209.09309387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
52
(253.20053100586): SELECT name FROM jos_deeppockets WHERE id=294774610 LIMIT 1
53
(128.98445129395): SELECT name FROM jos_deeppockets_archive WHERE id=294774610 LIMIT 1
54
(146.15058898926): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'
55
(68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294774610
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
56
(422.00088500977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294774610
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
57
(!!!!! 1148.9391326904): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
58
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
59
(100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
60
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
61
(123.02398681641): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 1
62
(555.99212646484): SELECT fid FROM jos_deeppockets WHERE id=294774610 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774610 AND published='1'  LIMIT 1
63
(284.91020202637): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
64
(46.968460083008): select jos_twitters.link from jos_twitters where cat=10
65
(27.894973754883): select jos_facebook.link from jos_facebook where cat=10
66
(30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10
67
(28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10
68
(33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294774610 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774610 AND published='1'  LIMIT 1
69
(61.988830566406): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
70
(543.11752319336): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294774610
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
71
(246.04797363281): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774610 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
72
(37.908554077148): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
73
(50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1
74
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
75
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
76
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
77
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
78
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
79
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
80
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
81
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
82
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
83
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
84
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
85
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
86
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
87
(41.961669921875): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294774610
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
88
(30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774610 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89
(32.901763916016): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
90
(355.95893859863): SELECT show_live FROM jos_com_show_setting LIMIT 1
91
(71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1
92
(93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1
93
(66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1
94
(95.129013061523): SELECT show_live FROM jos_com_show_setting LIMIT 1
95
(66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1
96
(40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
97
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
98
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
99
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
101
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
102
(82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1
103
(28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
104
(582.93342590332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
105
(59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
106
(55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294774610
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
107
(591.03965759277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294774610
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
108
(769.13833618164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
109
(147.81951904297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
110
(463.00888061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294774610
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
111
(490.18859863281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294774610
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
112
(540.01808166504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
113
(373.12507629395): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
114
(77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
115
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
116
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
117
(38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
118
(94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
119
(36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
120
(423.19297790527): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121
(!!!!! 38879.871368408): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7
122
(99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
123
(44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
124
(305.8910369873): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774610 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774610 AND type='deeppockets_item' AND published='1'  LIMIT 1
125
(!!!!! 535143.13697815): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
126
(95.844268798828): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
127
(241.04118347168): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
128
(41.961669921875): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
129
(138.0443572998): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
130
(36.001205444336): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
131
(104.90417480469): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
132
(91.075897216797): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
133
(716.9246673584): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294774610
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
134
(483.98971557617): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294774610
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
135
(274.8966217041): SELECT name FROM jos_deeppockets WHERE id=215
136
(31.948089599609): SELECT name FROM jos_deeppockets WHERE id=215
137
(614.16625976562): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
138
(458.0020904541): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
139
(334.02442932129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
140
(273.9429473877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
141
(!!!!! 14715.909957886): TRUNCATE TABLE jos_trademed_module
142
(346.89903259277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294774610
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
143
(97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294774610
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
144
(780.82084655762): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294774610
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145
(61.03515625): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294774610
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146
(53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
147
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
148
(!!!!! 3530.0254821777): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6
149
(155.92575073242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
150
(246.04797363281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
151
(107.0499420166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774610 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774610 AND type='deeppockets_item' AND published='1'  LIMIT 1
152
(102.04315185547): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
153
(113.96408081055): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
154
(636.10076904297): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155
(138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
156
(254.86946105957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774610 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774610 AND published='1'
		LIMIT 1
157
(106.8115234375): select jos_twitters.link from jos_twitters where cat=10
158
(27.894973754883): select jos_facebook.link from jos_facebook where cat=10
159
(26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10
160
(244.8558807373): select jos_linkedin.link from jos_linkedin where cat=10
161
(319.00405883789): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)
162
(!!!!! 2958.0593109131): insert into jos_banners_delta values (14615,'2025-04-30 17:17:26','18.118.14.81','view'),(14202,'2025-04-30 17:17:26','18.118.14.81','view'),(14203,'2025-04-30 17:17:26','18.118.14.81','view')