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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

New PET Tracer Images Epigenetics of the Human Brain

By MedImaging International staff writers
Posted on 25 Aug 2016

Image: Human brain MR-PET image using Martinostat (Photo courtesy of NMR).

A novel positron emission tomography (PET) radiotracer can help reveal epigenetic activity within the human brain, claims a new study.

Developed by researchers at the Martinos Center for Biomedical Imaging (NMR; Charlestown, MA, USA), part of Massachusetts General Hospital (MGH; Boston, USA), Martinostat is patterned after histone deacetylase (HDAC) inhibitors in order to tightly bind to HDAC molecules in the brain. PET scans of the brains of eight healthy human volunteers who received Martinostat revealed characteristic patterns of uptake--reflecting HDAC expression levels--that were consistent among all participants.

The results revealed that HDAC expression was almost twice as high in gray matter as in white matter; and within gray matter structures, uptake was highest in the hippocampus and amygdala, and lowest in the putamen and cerebellum. Experiments with brain tissues from humans and baboons confirmed Martinostat's binding to HDAC, and studies with neural progenitor stem cells revealed specific genes regulated by this group of HDACs, many of which are known to be important in brain health and disease. The study was published on August 10, 2016, in Science Translational Medicine.

“HDAC dysregulation has been implicated in a growing number of brain diseases, so being able to study HDAC regulation both in the normal brain and through the progression of disease should help us better understand disease processes,” said senior author associate professor of radiology Jacob Hooker, PhD. “We've now started studies of patients with several neurologic or psychiatric disorders, and I believe Martinostat will help us understand the different ways these conditions are manifested and provide new insights into potential therapies.”

“The ability to image the epigenetic machinery in the human brain can provide a way to begin understanding interactions between genes and the environment,” added Dr. Hooker. “This could allow us to investigate questions such as why some people genetically predisposed to a disease are protected from it? Why events during early life and adolescence have such a lasting impact on brain health? Is it possible to ‘reset’ gene expression in the human brain?”

Epigenetics is the study of heritable changes in gene expression that does not involve changes to the underlying DNA sequence--i.e. a change in phenotype without a change in genotype--which in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence, but can also be influenced by several factors including age, the environment/lifestyle, and disease state. Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells, etc. Epigenetic change can also have more damaging effects that can result in diseases like cancer.

Related Links:
Martinos Center for Biomedical Imaging
Massachusetts General Hospital

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63 (419.85511779785): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

64 (64.849853515625): select jos_twitters.link from jos_twitters where cat=10

65 (91.075897216797): select jos_facebook.link from jos_facebook where cat=10

66 (46.014785766602): select jos_google_plus.link from jos_google_plus where cat=10

67 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

68 (167.1314239502): SELECT fid FROM jos_deeppockets WHERE id=294765735 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294765735 AND published='1' LIMIT 1

69 (67.949295043945): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (308.99047851562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (280.85708618164): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (63.180923461914): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (122.0703125): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

105 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

106 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

110 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (422.00088500977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (761.03210449219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (474.92980957031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (214.81513977051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

115 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

116 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

117 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

118 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

120 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

121 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

122 (360.96572875977): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19315.004348755): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (490.90385437012): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765735 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765735 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7265.8061981201): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.983245849609): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (292.06275939941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (215.05355834961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (181.91337585449): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (289.9169921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (535.01129150391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (334.9781036377): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (200.03318786621): SELECT name FROM jos_deeppockets WHERE id=215

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=215

139 (583.17184448242): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (531.19659423828): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

142 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

143 (!!!!! 8138.89503479): TRUNCATE TABLE jos_trademed_module

144 (78.916549682617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294765735 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (774.86038208008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

149 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

150 (!!!!! 1104.1164398193): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

152 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

153 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294765735 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294765735 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (29.802322387695): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (25.98762512207): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (27.894973754883): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

158 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294765735 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294765735 AND published='1' LIMIT 1

159 (103.95050048828): select jos_twitters.link from jos_twitters where cat=10

160 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

161 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

162 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

163 (267.02880859375): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1102.9243469238): insert into jos_banners_delta values (14202,'2025-06-22 19:22:38','216.73.216.120','view'),(14203,'2025-06-22 19:22:38','216.73.216.120','view')

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