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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

New Imaging Agent Detects Rare Neuroendocrine Tumors

By MedImaging International staff writers
Posted on 23 Jun 2016

Image: Neuroendocrine tumor cells (Photo courtesy of MedScape).

A novel radioactive probe will help locate tumors in adult and pediatric patients suffering from somatostatin receptor positive neuroendocrine tumors (NETs).

Netspot, a product of Advanced Accelerator Applications (AAA; Saint-Genis-Pouilly, France), is a sterile, single-dose kit for the preparation of Ga 68 dotatate injection, a radioactive diagnostic agent used in positron emission tomography (PET) imaging. The imaging agent functions as an analogue of somatostatin, with uptake of the dotatate reflecting levels of somatostatin receptor density in NETs. As Netspot contributes to the overall long-term cumulative radiation exposure, patients should drink and urinate as often as possible during the first hours following administration to help reduce risk.

“Use of advanced imaging techniques to detect rare neuroendocrine tumors at an early stage in patients is critical,” said Libero Marzella, MD, PhD, director of the division of medical imaging products at the U.S. Food and Drug Administration (FDA, Silver Spring, MD, USA) Center for Drug Evaluation and Research (CDER). “Netspot provides another diagnostic tool whose results will help clinicians determine the location and extent of the tumor. This information is important for planning the appropriate course of therapy.”

“The FDA approval of Netspot is a key milestone in our mission of improving the lives of NET patients,” said Stefano Buono, CEO of AAA. “NETSPOT has the potential to significantly improve the accuracy of NET diagnosis, while reducing radiation exposure for patients. We believe that the use of Netspot should also offer increased comfort for patients by potentially shortening a procedure that is currently performed over 24 hours or more to just a few hours.”

NETs are rare benign or malignant tumors that develop in the hormone-producing cells of the body’s neuroendocrine system. These cells are found throughout the body in distinct organs, such as the stomach, intestines, pancreas, lungs, and other locations. NETs have receptors for somatostatin, a hormone that regulates the endocrine system. The estimated incidence of NETs for the combined populations of the United States and the European Union is approximately 47,300 patients per year.

Related Links:
Advanced Accelerator Applications
U.S. Food and Drug Administration

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67 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

68 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294764751 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294764751 AND published='1' LIMIT 1

69 (36.001205444336): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (430.82237243652): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (499.96376037598): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (49.114227294922): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.848648071289): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.186508178711): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

105 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

106 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (44.822692871094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

109 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

110 (44.822692871094): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (468.96934509277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (540.01808166504): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (551.93901062012): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

115 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

116 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

117 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

118 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

119 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

120 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

121 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

122 (304.9373626709): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 25356.05430603): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (896.93069458008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764751 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764751 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9860.9924316406): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (106.0962677002): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (64.849853515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (401.97372436523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (467.77725219727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (322.10350036621): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=215

138 (29.087066650391): SELECT name FROM jos_deeppockets WHERE id=215

139 (584.12551879883): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (519.0372467041): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

142 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

143 (!!!!! 8913.9938354492): TRUNCATE TABLE jos_trademed_module

144 (108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764751 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (591.03965759277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

149 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

150 (!!!!! 1620.0542449951): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

152 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

153 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764751 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764751 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

158 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764751 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764751 AND published='1' LIMIT 1

159 (36.001205444336): select jos_twitters.link from jos_twitters where cat=10

160 (29.802322387695): select jos_facebook.link from jos_facebook where cat=10

161 (33.855438232422): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

163 (278.94973754883): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 2366.0659790039): insert into jos_banners_delta values (14202,'2025-06-22 18:10:47','216.73.216.120','view'),(14203,'2025-06-22 18:10:47','216.73.216.120','view')

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