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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Multispectral Optoacoustic Tomography and siRNA Molecules Used as Nano-Guides to the Liver

By MedImaging International staff writers
Posted on 30 Dec 2014

Image: Scheme of a nanoparticle loaded with drug in the core (purple) and specific dye marker at the surface of the particle (blue dots) (Photo courtesy of JCSM/SmartDyeLivery, GmbH).

Highly specific nanoparticles have been developed that, depending on the bound dye, are guided to the liver or to the kidney and designed to deliver their cargo of active ingredients directly to the targeted tissue.

The reduction of cholesterol production induced by small interfering RNA-molecule (siRNA) served as the proof-of-principle for the developed technology. The scientists have been successful in generating very specific nanoparticles. Depending on the bound dye the particles are guided to the liver or to the kidney and deliver their cargo of active substances directly to the targeted tissue. Moreover, the dyes enable the monitoring of the transport processes by intravital microscopy or, in a noninvasive way, by multispectral optoacoustic tomography. The reduction of cholesterol production triggered by siRNA served as the proof-of-principle for the developed method. The scientists, from Friedrich Schiller University Jena (Germany), reported their data December 3, 2014, in the scientific journal Nature Communications.

This new technology is one of the great hopes for target-oriented treatment approaches: the so-called siRNA. These are able to silent specific genes, by preventing them from generating proteins that are encoded on them. To accomplish this, the siRNA has to be delivered specifically into the targeted cells to perform only there and nowhere else. Moreover, the siRNA should not be just excreted or, even worse, damage healthy tissue. This is what makes the management of siRNA extremely difficult. Physicians and chemists from Jena and Munich (Germany) and the United States have now succeeded in creating nanotransporters for this genetic material, which are able to specifically and effectively target selected cell types and release their active payload there.

The particles which are based on polymers are marked with near infrared fluorescent dyes and loaded with siRNA. The dyes work similar to address labels and tracking numbers for the particles all in one. “Depending on the chemical structure of the dye the particles are filtered out of the blood either via the kidney tissue or via liver cells. At the same time, this route can easily be tracked by optical methods with the aid of the dyes,” stated intensive care physician Prof. Dr. Michael Bauer. His research team at the Jena University Hospital Centre for Sepsis Control and Care (CSCC) was also able to demonstrate that the dye is specifically absorbed by a specific cellular transporter of the liver epithelial cells and taken up into the cells.

In this manner, the siRNA load is exclusively released in the target cells. The specifically functionalized nanocontainers have been designed and produced in the laboratories of the Jena Center for Soft Matter (JCSM) of the Friedrich Schiller University in Jena. “This method can be regarded as a kind of toolbox for a multitude of different siRNA-nanotransporters which can ensure the targeted, switch-off of specific protein biosynthesis in different cell types,” stated the director of the JCSM, Prof. Dr. Ulrich S. Schubert.

With the possibility to test the non-coupled dyes in advance and to switch off genes, which are associated with illnesses, the principle offers new approaches to a personalized therapy of various diseases. In the newly founded SmartDyeLivery, GmbH, the scientists want to further develop the technology to use it in the clinical environment, particularly in cases of acute septic infections.

The nanomedicine researchers clarified in their study the working basis of their toolbox using the example of cholesterol production. They loaded the nanoparticles with targeting dyes attached with siRNA-molecules. The siRNA molecules interfered with cholesterol production in hepatocytes, which resulted in a distinct reduction in the cholesterol level in the blood of test animals.

Related Links:
Friedrich Schiller University Jena

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60 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

61 (!!!!! 8574.9626159668): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (675.20141601562): SELECT fid FROM jos_deeppockets WHERE id=294756454 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756454 AND published='1' LIMIT 1

63 (54.836273193359): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

64 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

65 (332.83233642578): select jos_facebook.link from jos_facebook where cat=10

66 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

67 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

68 (117.06352233887): SELECT fid FROM jos_deeppockets WHERE id=294756454 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756454 AND published='1' LIMIT 1

69 (!!!!! 2722.0249176025): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (!!!!! 2067.0890808105): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (440.12069702148): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (52.928924560547): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2728.9390563965): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (96.08268737793): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (37.193298339844): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

105 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

106 (64.13459777832): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (623.22616577148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

109 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

110 (68.902969360352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (782.01293945312): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 2820.9686279297): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1103.1627655029): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (126.12342834473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

115 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

116 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

117 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

118 (!!!!! 1296.9970703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

119 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

120 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

121 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

122 (553.84635925293): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 68426.847457886): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1384.0198516846): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756454 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756454 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 21646.022796631): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (62.942504882812): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (353.09791564941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 4498.9585876465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (!!!!! 6283.9984893799): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 5774.0211486816): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 3768.9208984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 2239.9425506592): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (188.11225891113): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1491.0697937012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (526.18980407715): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (55.074691772461): SELECT name FROM jos_deeppockets WHERE id=215

138 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=215

139 (643.96858215332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (478.02925109863): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (383.85391235352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

142 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

143 (!!!!! 10035.991668701): TRUNCATE TABLE jos_trademed_module

144 (603.91426086426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756454 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (502.8247833252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (316.85829162598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (448.94218444824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

149 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

150 (!!!!! 1808.8817596436): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (371.93298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

152 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

153 (309.94415283203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756454 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756454 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (301.12266540527): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

158 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756454 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756454 AND published='1' LIMIT 1

159 (380.9928894043): select jos_twitters.link from jos_twitters where cat=10

160 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

163 (518.798828125): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1172.0657348633): insert into jos_banners_delta values (14202,'2025-06-23 14:14:17','216.73.216.120','view'),(14203,'2025-06-23 14:14:17','216.73.216.120','view')

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