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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

3D Optical Projection Tomography Imaging Detects Lung Cancer with High Sensitivity, Specificity

By MedImaging International staff writers
Posted on 06 Nov 2013

Image: The Cell-CT platform enables the quantitative analysis of the in situ 3D distribution of targeted molecular markers, stains and other absorbing structures within a cell at submicron resolution in a manner that links to traditional pathology, but with the third dimension (Photo courtesy of VisionGate).

A new study showed that a new automated three-dimensional (3D) cell-imaging platform could identify lung cancer in sputum samples with high sensitivity and specificity.

The Cell-CT technology, developed by VisionGate, Inc. (Sydney, Australia), a company developing a noninvasive test for the early detection of lung cancer, uses a technique called optical projection tomography to image cells in 3D. A cell is transported through the Cell-CT’s glass micro-capillary by applying pressure to a gel that embeds cells. As the capillary spins, the cell is scanned from multiple perspectives, providing a set of pseudo-projection images. These images are combined together using a method known as filtered back-projection, producing the final 3D cell volume.

These new findings were presented at the International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer, held October 27-30, 2013, in Sydney (NSW, Australia). The pilot study analyzed sputum samples from patients with confirmed lung cancer and from healthy individuals. The findings revealed that the Cell-CT platform and the LuCED sputum test effectively detected the presence or absence of lung cancer cells in patient sputum from a spontaneous cough. In the 53 individuals studied up to now, LuCED and the Cell-CT achieved a sensitivity of more than 95% and specificity of 99.8%. The high sensitivity indicates that the Cell-CT detects most tumors, and the high specificity means that the rate of false-positive readings is exceedingly low. This is far greater accuracy than has been demonstrated with any other lung cancer-screening test.

“Lung cancer remains the leading cause of cancer death in the US, primarily because it is not detected until after the cancer has spread,” commented Alan Nelson, PhD, founder and CEO of VisionGate. “Results to date from this ongoing clinical study suggest that LuCED and the Cell-CT correctly identify more than nine out of every 10 cases of lung cancer with virtually no false-positive results, supporting the goal of developing a new lung cancer screening paradigm that is both accurate and cost-effective.”

The automated Cell-CT platform creates extremely clear and detailed 3D digital images of the cells contained in sputum. It uses sophisticated algorithms to identify the presence or absence of cell biosignatures tied to malignant or normal status, making it possible to determine with great accuracy whether a patient has cancer.

Low-dose computed tomography (CT) screening can detect lung cancer at early stages and save lives. However, CT screening has a very high rate of false-positive results, which can require expensive and invasive follow-up procedures. The large US National Cancer Institute (NCI; Bethesda, MD, USA) National Lung Screening Trial showed that more than 96% of the “positive” results from CT screening were actually false-positives. As a result, its use is recommended only in the highest-risk individuals. The potential ability of VisionGate’s Cell-CT platform to noninvasively and cost-effectively confirm or contradict positive findings from CT scans would make widespread use of lung cancer screening far more feasible.

Glen J. Weiss, MD, director of clinical research, Cancer Treatment Centers of America Western Regional Medical Center (Goodyear, AZ, USA), noted, “The urgency of developing accurate, cost-effective tools for early detection of lung cancer is highlighted by the thousands of preventable lung cancer deaths each year. These data showing that the Cell-CT platform can detect lung cancer with high accuracy from sputum samples in patients at all stages of the disease, as well as identifying those who are cancer-free, is very encouraging. We look forward to continuing to work with VisionGate to enlarge the study population and generate the data needed to advance development of this promising lung cancer screening test.”

Earlier research had validated that analyzing cells in sputum could be useful in the early detection of lung cancer. However, the typically poor sensitivity of raw sputum analysis and the labor-intensive nature of the process made it impracticable for widespread use. The Cell-CT’s high-resolution 3D technology and its automated image analysis software for the first time make a cell-based diagnostic approach using sputum samples logistically practicable and cost-effective.

Scarlett Spring, president of VisionGate, added, “We soon expect to supplement these exciting efficacy results with peer-reviewed economic analysis data that confirm the cost-effectiveness of our approach. We also are expanding our collaborative efforts with a variety of institutions as we focus on generating the additional data needed to gain FDA regulatory clearance of LuCED and the Cell-CT platform for adjunctive use with X-ray CT screening, and then possibly as a stand-alone test for lung cancer screening that would be readily available at moderate cost to the broader population.”

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56 (359.05838012695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 2077.1026611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

58 (913.85841369629): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

59 (!!!!! 1363.99269104): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

60 (321.86508178711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

61 (!!!!! 3385.066986084): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (687.1223449707): SELECT fid FROM jos_deeppockets WHERE id=294749020 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749020 AND published='1' LIMIT 1

63 (!!!!! 1185.8940124512): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

64 (544.07119750977): select jos_twitters.link from jos_twitters where cat=10

65 (909.80529785156): select jos_facebook.link from jos_facebook where cat=10

66 (32.901763916016): select jos_google_plus.link from jos_google_plus where cat=10

67 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.040740966797): SELECT fid FROM jos_deeppockets WHERE id=294749020 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749020 AND published='1' LIMIT 1

69 (29.087066650391): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (180.95970153809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1252.8896331787): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (199.0795135498): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (133.99124145508): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (72.956085205078): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (47.206878662109): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (236.03439331055): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (211.00044250488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

105 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

106 (83.92333984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

109 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

110 (119.92454528809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (500.91743469238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (844.00177001953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (348.09112548828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1842.0219421387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

115 (!!!!! 2640.962600708): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

116 (188.82751464844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

117 (443.93539428711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

118 (231.02760314941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

119 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

120 (114.20249938965): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

121 (!!!!! 2068.9964294434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

122 (223.15979003906): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 168395.99609375): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 2053.0223846436): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749020 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749020 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 37843.942642212): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (67.949295043945): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (278.94973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (511.88468933105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (385.99967956543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (196.93374633789): SELECT name FROM jos_deeppockets WHERE id=215

138 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=215

139 (!!!!! 4747.8675842285): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (624.8950958252): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

142 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

143 (!!!!! 29844.999313354): TRUNCATE TABLE jos_trademed_module

144 (915.0505065918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749020 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (491.14227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

149 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

150 (!!!!! 1183.032989502): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

152 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

153 (34.093856811523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749020 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749020 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (27.894973754883): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (962.97264099121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

158 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749020 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749020 AND published='1' LIMIT 1

159 (46.014785766602): select jos_twitters.link from jos_twitters where cat=10

160 (27.179718017578): select jos_facebook.link from jos_facebook where cat=10

161 (27.179718017578): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

163 (267.98248291016): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 23216.009140015): insert into jos_banners_delta values (14202,'2025-06-23 15:14:27','216.73.216.120','view'),(14203,'2025-06-23 15:14:27','216.73.216.120','view')

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