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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Optical Mammography Effectively Diagnoses Breast Cancer

By MedImaging International staff writers
Posted on 10 Oct 2012

Image: Shown is an optical mammography image of hemoglobin oxygenation of a duct carcinoma in situ (DCIS), a breast cancer in the lining of the milk ducts that has not yet invaded nearby tissues. In this image, the boxed area corresponds to the cancer location and indicates lower values of hemoglobin oxygenation. For cancerous tissue that is associated with abnormal hemoglobin concentration and oxygenation, optical mammography can be used to help diagnose breast cancer and also indicate how well a patient responds to breast cancer chemotherapy (Photo courtesy of Tufts University Medical Center).

New optical imaging technology could provide clinicians with strategies to both identify breast cancer and track individual patients’ response to initial treatment of the disease.

The noninvasive technology utilizes near infrared (NIR) light to scan breast tissue, and then applies an algorithm to interpret the data. Differences in light absorption allow identification of water, fats, and oxygen-rich and oxygen-poor tissue, the basic structures in breast tissue.

A five-year clinical study of the procedure, funded by a USD 3.5 million grant from the US National Institutes of Health (NIH; Bethesda, MD, USA), is now underway at Tufts University Medical Center (Boston, MA, USA).

“The consensus is that X-ray mammography is very good at detecting lesions but it’s not as good at determining which suspicious lesions are really cancer,” said professor of biomedical engineering Sergio Fantini, PhD, who is leading the research project. The Tufts NIR technique could complement traditional mammography, particularly for women younger than 40 who may have dense breast tissue that has a tendency to blur features in X-rays.

The NIR technique, because it does not employ ionizing radiation, can be applied multiple times over a short period without risk of radiation exposure, Dr. Fantini noted. Another benefit of the technology is that, dissimilar to other breast imaging modalities, it can gather functional real-time images of metabolic alterations, such as levels of hemoglobin concentration and oxygenation.

“It’s been reported that patients who respond to breast cancer chemotherapy show a decrease in hemoglobin and water concentration and an increase in lipid concentration at the cancer site,” explained Dr. Fantini. “This suggests that NIR imaging can be valuable not only in diagnosing breast cancer but in monitoring individual response to therapies without requiring repeated X-rays. For example, it could help determine if a patient is responding to neoadjuvant chemotherapy administered to shrink a tumor before surgery.”

Optical mammography is also more comfortable than standard mammograms. The patient’s breasts are only slightly compressed between two horizontal glass panels and then illuminated by NIR light. A specialized software program displays real-time images of the breast as the optical system scans back and forth. A light detector within the system displays the intensity of the NIR beam as it is transmitted through the breast.

By using an algorithm based on the optical data, the technology generates breast images utilizing the intensity of the transmitted light. The images are displayed automatically and can be read soon after the procedure, as is the case with X-ray mammograms. The technology can be fit into compact, portable, and handheld devices.

In collaboration with Roger Graham, MD, director of Tufts Medical Center’s Breast Health Center, and Marc Homer, MD, chief of mammography at Tufts Medical Center, Dr. Fantini and colleagues conducted proof of concept evaluations to see if their procedure could validate data gathered with X-rays on two patients who each had suspicious lesions in one of their breasts.

The optical imaging was effective in enabling the investigators to identify cancerous tissue. “The test results were compatible with what we found in the X-ray mammography,” Dr. Graham stated. “It was also painless for the patients and eliminated radiation exposure.”

The NIH-funded study will examine women with breast cancer, healthy women, and women with benign breast lesions in an effort to investigate the effectiveness of optical mammography in identifying breast cancer and differentiating between malignant and benign tumors. The study will also assess breast cancer patients who are undergoing chemotherapy in to clarify the ability of optical mammography to determine patient response at the beginning of therapeutic treatment.

Related Links:
Tufts University Medical Center

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59 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

60 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

61 (141.14379882812): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (689.98336791992): SELECT fid FROM jos_deeppockets WHERE id=294742889 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294742889 AND published='1' LIMIT 1

63 (488.0428314209): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

64 (77.009201049805): select jos_twitters.link from jos_twitters where cat=10

65 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

66 (50.067901611328): select jos_google_plus.link from jos_google_plus where cat=10

67 (42.915344238281): select jos_linkedin.link from jos_linkedin where cat=10

68 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE id=294742889 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294742889 AND published='1' LIMIT 1

69 (48.87580871582): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (406.98051452637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (319.00405883789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (58.174133300781): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (66.995620727539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (37.908554077148): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

105 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

106 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (65.803527832031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

109 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

110 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (669.95620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (736.95182800293): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (541.92543029785): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (192.16537475586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

115 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

116 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

117 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

118 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

120 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

121 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

122 (416.99409484863): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 28968.095779419): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (736.95182800293): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742889 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742889 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10269.8802948): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (188.11225891113): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (415.08674621582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (48.87580871582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (612.97416687012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (487.8044128418): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (336.88545227051): SELECT name FROM jos_deeppockets WHERE id=215

138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=215

139 (756.97898864746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (675.91667175293): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

142 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

143 (!!!!! 10869.026184082): TRUNCATE TABLE jos_trademed_module

144 (92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294742889 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (871.89674377441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

149 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

150 (!!!!! 1163.9595031738): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

152 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

153 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294742889 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294742889 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (41.007995605469): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

158 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294742889 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294742889 AND published='1' LIMIT 1

159 (60.796737670898): select jos_twitters.link from jos_twitters where cat=10

160 (42.915344238281): select jos_facebook.link from jos_facebook where cat=10

161 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

162 (42.915344238281): select jos_linkedin.link from jos_linkedin where cat=10

163 (425.10032653809): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

164 (!!!!! 1147.0317840576): insert into jos_banners_delta values (14202,'2025-06-23 20:29:30','216.73.216.120','view'),(14203,'2025-06-23 20:29:30','216.73.216.120','view')

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