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Developmental Drug Helps Protect Against Radiation Damage

By MedImaging International staff writers
Posted on 19 May 2009

A drug currently under development has been shown to protect cells from the damaging effects of radiation exposure, a new study suggests.

The findings of the study were presented at the 100th annual meeting of the American Association for Cancer Research (AACR), April 18-22, 2009, in Denver, CO, USA. The study, led by Joel Greenberger, M.D., professor and chairman of the department of radiation Oncology at the University of Pittsburgh School of Medicine (Pitt; PA, USA), is overseen by Pitt's Center for Medical Countermeasures Against Radiation. The center is dedicated to identifying and developing small molecule radiation protectors and mitigators that can be easily accessed and administered in the event of a large-scale radiological or nuclear emergency.

JP4-039, the new developmental drug assists mitochondria, the energy generator of all cells, in combating irradiation-induced cell death. For this study, cells treated immediately after irradiation with JP4-039 demonstrated significant radioprotection, suggesting a potential role for the drug as a mitigator of radiation damage.

"Currently, no drugs on the market counteract the effects of radiation exposure,” said Dr. Greenberger. "We know this drug can counteract the damage caused by irradiation, and now we want to develop the ideal dosage, one that is effective for the general population while remaining nontoxic. Our goal is to take this drug through a phase I clinical trial, and once the dosage is established, develop the drug for late-stage clinical trials and market licensing.”

This study was funded by the Biomedical Advanced Research and Development Authority (BARDA), U.S. Department of Health and Human Services (Washington, DC, USA). In 2008, BARDA awarded Dr. Greenberger and members of his lab US$2.7 million to help develop a radiation mitigator drug that could counteract the effects of radiation exposure in case of large-scale public exposure. The ultimate goal of the contract is to develop an easily administered drug that the Centers for Disease Control and Prevention in the Department of Health and Human Services can store and fly to hospitals and care facilities if and when an emergency occurs.

Related Links:
University of Pittsburgh School of Medicine
Biomedical Advanced Research and Development Authority
Centers for Disease Control and Prevention

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65 (!!!!! 7730.0071716309): select jos_facebook.link from jos_facebook where cat=10

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67 (!!!!! 8877.0389556885): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 4523.9925384521): SELECT fid FROM jos_deeppockets WHERE id=294723256 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294723256 AND published='1' LIMIT 1

69 (!!!!! 6516.9334411621): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (!!!!! 6784.9159240723): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 7674.9324798584): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 8284.8072052002): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 2439.9757385254): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (367.16461181641): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (216.00723266602): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (!!!!! 4747.8675842285): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (859.02214050293): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (403.16581726074): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (507.83157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (!!!!! 1358.9859008789): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (288.00964355469): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (131.13021850586): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (406.98051452637): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (283.95652770996): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (669.00253295898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (135.89859008789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (169.03877258301): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1928.0910491943): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (401.97372436523): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 1622.9152679443): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (930.7861328125): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (334.02442932129): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (222.92137145996): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (!!!!! 2294.0635681152): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 1003.0269622803): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (175.95291137695): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1718.0442810059): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (468.96934509277): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4426.0025024414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

105 (!!!!! 3921.9856262207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

106 (!!!!! 5574.9416351318): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (619.88830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 6964.9219512939): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

109 (!!!!! 8035.8982086182): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

110 (!!!!! 6873.1307983398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1098.1559753418): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1299.8580932617): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1180.1719665527): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (849.00856018066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

115 (306.84471130371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

116 (!!!!! 1003.9806365967): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

117 (526.18980407715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

118 (!!!!! 2372.9801177979): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

119 (427.0076751709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

120 (!!!!! 1075.9830474854): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

121 (219.10667419434): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

122 (!!!!! 1900.9113311768): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 80227.851867676): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1315.1168823242): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723256 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723256 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (65.088272094727): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (52.928924560547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (85.830688476562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 2309.0839385986): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (265.12145996094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (136.13700866699): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 1655.101776123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (694.03648376465): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (703.09638977051): SELECT name FROM jos_deeppockets WHERE id=215

138 (251.05476379395): SELECT name FROM jos_deeppockets WHERE id=215

139 (!!!!! 1666.0690307617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1405.0006866455): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1363.0390167236): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

142 (576.01928710938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

143 (!!!!! 17373.085021973): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 3114.9387359619): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (111.81831359863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294723256 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (389.09912109375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 1486.06300354): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 4251.9569396973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

149 (!!!!! 9392.9767608643): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

150 (!!!!! 7349.0142822266): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 8059.9784851074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

152 (!!!!! 7952.9285430908): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

153 (!!!!! 7442.9512023926): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294723256 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294723256 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (399.11270141602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (746.01173400879): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (804.18586730957): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 1230.001449585): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

158 (!!!!! 4019.9756622314): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294723256 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294723256 AND published='1' LIMIT 1

159 (646.11434936523): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 2557.9929351807): select jos_facebook.link from jos_facebook where cat=10

161 (339.98489379883): select jos_google_plus.link from jos_google_plus where cat=10

162 (!!!!! 3806.1141967773): select jos_linkedin.link from jos_linkedin where cat=10

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