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Imaging Technique Tracks Cancer-Killing Cells over Long Periods in First-Ever Study

By MedImaging International staff writers
Posted on 16 Dec 2008

Persuading a patient's own cells to search and destroy infected or diseased cells is a promising therapeutic approach for many disorders. But until now, efforts to track these specially modified cells after their reintroduction to the body have relied on short-term monitoring techniques that do not provide a complete picture of the cells' status.

Now, for the first time, researchers from the Stanford University School of Medicine (CA, USA; http://med.stanford.edu) have devised a way to obtain repeated "snapshots” of the location and survival of such cells in a living human patient months and possibly years later. This is a promising application for individual patients and clinicians who may want to assess the cells' disease-fighting performance over time, as well as for researchers trying to design more effective cell-based therapies.

"This has never before been done in a human,” said the senior author of the research, Sanjiv Gambhir, M.D., Ph.D., director of Stanford's Molecular Imaging Program. "Until now, we've been shooting blind-never knowing why failed therapies didn't work. Did the cells die? Did they not get where we wanted them to go? Now we can repeatedly monitor them throughout their lifetime.” Dr. Gambhir is a professor of radiology and a member of Stanford's Cancer Center. He collaborated with researchers at City of Hope in Los Angeles (CA, USA) and at the University of California, Los Angeles (UCLA; USA) to conduct the research.

Dr. Gambhir and his colleagues evaluated the technique in a middle-aged man with an aggressive brain tumor (called a glioblastoma) who was enrolled in a clinical trial of cell-based therapy at City of Hope. However, they believe similar strategies will work to monitor cell-based therapies for many disorders. The results of the case study was published online November 18, 2008, in the journal Nature Clinical Practice Oncology.

The new approach relies on a two-step process: first, the therapeutic cells are engineered to express a unique reporter gene shared by no other cells in the body. Second, an imaging agent that is trapped only in cells expressing the reporter gene is injected into the patient. The unbound imaging agent is otherwise quickly cleared from the body. Each time the imaging agent is used, the researchers get a new, up-to-date map showing the cells' locations.

The technique has several advantages over previous tracking methods. Unlike an external radioactive tag, which decays over a short time and does not indicate whether a cell is living or dead, the reporter gene is expressed throughout a cell's lifetime, but not beyond. Furthermore, unlike an external tag, the reporter gene is duplicated and passed along if the original cell divides. Finally, different reporter genes can be used that may well indicate not only the location of the cells, but also what they are up to.

"In this patient, the reporter gene was always on,” said Dr. Gambhir. "But the beauty of this approach is that we could make it so the reporter gene is expressed only if the cell differentiates, or finds a certain target. Has the T cell found a tumor? Has it activated its cell-killing machinery?”

In the current study, Dr. Gambhir collaborated with Michael Jensen, M.D., associate chair of the cancer immunotherapeutics and tumor immunology program at City of Hope, and other researchers to remove cytotoxic, or "killer,” T cells from a male patient with glioblastoma. These cells naturally seek out and destroy infected or dysfunctional cells in the body. The researchers then inserted a circle of DNA encoding two key genes into these T cells. One endowed the cells with the ability to home in on the cancer cells. The other encoded a gene from a herpes simplex virus called thymide kinase, or HSV1-tk. The product of the HSV1-tk gene traps a radioactively labeled imaging molecule that can be visualized on a PET scan. Any imaging molecule that is not trapped in the modified T cells is eliminated from the body. A clinical PET-CT scanner tracks the locations of the imaging molecule and therefore the modified T cells.

The researchers then returned the modified T cells to the site of the patient's brain tumor over a period of five weeks. The patient received the imaging agent three days after the last infusion of cells. As the researchers had hoped, the following positron emission tomography-computed tomography (PET-CT) imaging scan revealed that the T cells had narrowed in on the tumor. However, they also migrated through the patient's brain to highlight a second, previously unsuspected tumor site. Although this study did not evaluate the capability of the T cells to kill the tumor cells, the imaging results suggested they did indeed arrive at their targets.

"The cells were actually good at finding the tumor,” said Dr. Gambhir, who pointed out that the same technique could be used to follow other immune cells or ultimately stem cells throughout the body. He plans to collaborate with other researchers at Stanford and elsewhere to not only continue his study with T cells and other tumor types, but also to investigate the movement of therapeutic cells in patients with arthritis and diabetes. "It took all of the institutions to come together to make such a complex trial work, but, because we're not limited to just one cell population, the results are tremendously exciting.”

Related Links:
Stanford University School of Medicine
University of California, Los Angeles

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56 (391.00646972656): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1186.1324310303): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (!!!!! 5433.7978363037): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

59 (275.1350402832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

60 (!!!!! 4076.0040283203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

61 (627.04086303711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

62 (!!!!! 2930.8795928955): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (!!!!! 5219.9363708496): SELECT fid FROM jos_deeppockets WHERE id=294721413 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721413 AND published='1' LIMIT 1

64 (599.14588928223): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

65 (827.07405090332): select jos_twitters.link from jos_twitters where cat=10

66 (85.115432739258): select jos_facebook.link from jos_facebook where cat=10

67 (49.829483032227): select jos_google_plus.link from jos_google_plus where cat=10

68 (47.922134399414): select jos_linkedin.link from jos_linkedin where cat=10

69 (380.9928894043): SELECT fid FROM jos_deeppockets WHERE id=294721413 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294721413 AND published='1' LIMIT 1

70 (59.127807617188): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

71 (!!!!! 1549.9591827393): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (782.96661376953): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (241.04118347168): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (270.12825012207): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (185.96649169922): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (882.86399841309): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (!!!!! 6479.024887085): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (260.1146697998): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (657.08160400391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (250.10108947754): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (916.95785522461): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (!!!!! 1070.9762573242): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (48.87580871582): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (319.9577331543): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (!!!!! 4883.0509185791): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (359.05838012695): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (149.96528625488): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (304.9373626709): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (850.20065307617): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (!!!!! 2233.9820861816): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (535.01129150391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (422.00088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (282.04917907715): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (108.00361633301): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (337.12387084961): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (!!!!! 3385.066986084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

106 (!!!!! 1250.9822845459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

107 (!!!!! 1677.0362854004): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1299.1428375244): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (!!!!! 7862.0910644531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

110 (!!!!! 4816.0552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

111 (!!!!! 1063.8236999512): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (722.88513183594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 1697.0634460449): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1079.0824890137): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (!!!!! 12523.174285889): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

116 (482.08236694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

117 (!!!!! 1471.0426330566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

118 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

119 (925.06408691406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

120 (298.02322387695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

121 (!!!!! 1054.048538208): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

122 (459.19418334961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

123 (365.9725189209): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 80251.932144165): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (688.07601928711): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721413 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721413 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 12209.892272949): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 9152.889251709): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (!!!!! 7766.0083770752): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 7999.8970031738): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (!!!!! 11475.086212158): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 7994.1749572754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 7903.0990600586): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 7986.0687255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (!!!!! 7614.1357421875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 7980.1082611084): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (!!!!! 1101.016998291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (982.99980163574): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (709.77210998535): SELECT name FROM jos_deeppockets WHERE id=215

139 (!!!!! 2444.9825286865): SELECT name FROM jos_deeppockets WHERE id=215

140 (!!!!! 1729.9652099609): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1013.0405426025): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (538.11073303223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

143 (641.1075592041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

144 (!!!!! 22253.99017334): TRUNCATE TABLE jos_trademed_module

145 (!!!!! 6885.0517272949): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (124.93133544922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294721413 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (!!!!! 4876.8520355225): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (790.83442687988): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (316.14303588867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

150 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

151 (!!!!! 3554.105758667): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (!!!!! 3873.8250732422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

153 (414.13307189941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

154 (!!!!! 3566.9803619385): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294721413 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294721413 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (!!!!! 3774.1661071777): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (140.19012451172): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

157 (!!!!! 5078.0773162842): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (432.01446533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

159 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294721413 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294721413 AND published='1' LIMIT 1

160 (!!!!! 3669.0235137939): select jos_twitters.link from jos_twitters where cat=10

161 (111.81831359863): select jos_facebook.link from jos_facebook where cat=10

162 (47.922134399414): select jos_google_plus.link from jos_google_plus where cat=10

163 (190.01960754395): select jos_linkedin.link from jos_linkedin where cat=10

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