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Imaging Reveals New Pathway for Anti-Cancer Treatment

By MedImaging staff writers
Posted on 22 May 2008

Researchers have discovered a possible new pathway for anti-tumor drugs to kill cancer cells and proposed how to improve the design of tiny drug-delivery particles for use in "nanomedicine.”

The synthetic "polymer micelles” are drug-delivery spheres 60-100 nanometers in diameter, or about 100 times smaller than a red blood cell. The spheres contain drugs in their inner core and contain an outer shell made of a material called polyethylene glycol.

Researchers showed for the first time how this shell of polyethylene glycol latches onto the membranes of cancer cells, allowing fluorescent probes mimicking cancer drugs to enter the cancer cells, according to Dr. Ji-Xin Cheng, an assistant professor in the Weldon School of Biomedical Engineering and department of chemistry at Purdue University (West Lafayette, IN, USA). "This is an interesting new step in developing nanomedicine techniques in drug delivery,” he said.

The research is being led by Dr. Cheng and Dr. Kinam Park, a professor of biomedical engineering and pharmaceutics. New findings are detailed in two research articles. One study was published in the May 6, 2008 issue of the Proceedings of the [U.S.] National Academy of Sciences (PNAS), and another study was published in the May 2008 issue of the journal Langmuir.

The researchers utilized an imaging technique called Förster resonance energy transfer imaging (FRET) to make two significant findings: how fluorescent molecules mimicking the cancer drug paclitaxel enter tumor cells and how the micelles break down in the blood before they have an opportunity to deliver the drug to cancer cells.

An important feature of micelles is that they combine two types of polymers, one being hydrophobic, and the other hydrophilic, meaning they are either unable or able to mix with water. The hydrophobic core was loaded with a green dye and the hydrophilic part labeled with a red dye.

Experiments demonstrated that "core-loaded” fluorescent molecules mimicking the drug entered cancer cells within 15 minutes, suggesting a new drug-delivery pathway to destroy tumor cells, according to Dr. Cheng. The fluorescent probes produced a green color on the membranes and a yellowish color inside the cells. "So this technique provides a system to monitor in real time how well anti-cancer drug delivery is working,” Dr. Cheng said.

Further findings made by the investigators using mice demonstrate specifically how the drug is released prematurely in the blood. "We first proved that micelles are unstable in the blood, and then we answered why they don't remain intact,” Dr. Cheng said.

The researchers also propose a possible way to correct the problem by "crosslinking,” or reinforcing polymer strands in the micelles with chemical bonds made of two sulfur atoms. This reinforced structure might remain intact in the blood long enough to deliver the micelles to tumor sites, where they would biodegrade, according to Dr. Cheng.

The researchers are the first to use FRET to study drug release from polymer micelles into a tumor cell. Because micelles remain intact in water, researchers had thought the particles were stable in blood, but Canadian scientists in 2003 showed that the micelles are quickly broken down, releasing the drug into the blood. "The reason is very simple,” Dr. Cheng said. "Unlike water, blood has many components like surfactants and lipids and proteins that interact with the whole micelle structure. As a result, the micelles are unstable in blood and the drug is released too soon.”

The Purdue researchers evaluated how stable micelles are in different blood components. Findings indicated that the micelles remained intact in red blood cells and components of blood plasma except for a class of plasma proteins called alpha and beta globulins, which caused the drug to be released. "There could also be other blood components that cause the drug to be released, but our proposal of using crosslinking could prevent this from happening,” Dr. Cheng said.

Future study, according to the researchers, may concentrate on creating micelles that remain intact longer in the blood by using crosslinking.

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61 (!!!!! 11436.939239502): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 5379.9152374268): SELECT fid FROM jos_deeppockets WHERE id=282890000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=282890000 AND published='1' LIMIT 1

63 (!!!!! 2597.8088378906): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

64 (!!!!! 5868.9117431641): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 5965.9481048584): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 2792.8352355957): select jos_google_plus.link from jos_google_plus where cat=10

67 (345.94535827637): select jos_linkedin.link from jos_linkedin where cat=10

68 (283.95652770996): SELECT fid FROM jos_deeppockets WHERE id=282890000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=282890000 AND published='1' LIMIT 1

69 (!!!!! 1770.01953125): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (385.04600524902): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (232.93495178223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 1142.0249938965): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (!!!!! 2170.0859069824): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (550.0316619873): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.982040405273): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (42.915344238281): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 1572.1321105957): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (954.86640930176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

105 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

106 (904.79850769043): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (667.09518432617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2883.9111328125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

109 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

110 (!!!!! 1358.0322265625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (485.89706420898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (741.00494384766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (374.07875061035): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

115 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

116 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

117 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

118 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

120 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

121 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

122 (369.78721618652): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 47147.035598755): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (571.01249694824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=282890000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=282890000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16360.998153687): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (84.877014160156): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (322.81875610352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (479.93659973145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (394.10591125488): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (280.85708618164): SELECT name FROM jos_deeppockets WHERE id=215

138 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=215

139 (599.14588928223): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (485.89706420898): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (76.770782470703): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

142 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

143 (!!!!! 35768.032073975): TRUNCATE TABLE jos_trademed_module

144 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (853.06167602539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=282890000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 4999.1607666016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 4113.9125823975): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (767.94624328613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

149 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

150 (!!!!! 1718.9979553223): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (413.17939758301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

152 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

153 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=282890000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=282890000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

156 (579.833984375): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

158 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=282890000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=282890000 AND published='1' LIMIT 1

159 (48.160552978516): select jos_twitters.link from jos_twitters where cat=10

160 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

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