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Guerbet and Bracco Enter Into Global Collaboration for Next-Generation MRI Contrast Agent Gadopiclenol

By MedImaging International staff writers
Posted on 15 Dec 2021

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Guerbet (Paris, France) and Bracco Imaging S.p.A. (Milan, Italy) have signed a global collaboration for Gadopiclenol, a next-generation magnetic resonance imaging (MRI) contrast agent, that will result in the companies commercializing the product independently under different brand names. The companies will also collaborate on manufacturing, as well as research and development for future indications.

A next-generation, macrocyclic gadolinium-based contrast agent with high relaxivity, Gadopiclenol is intended to improve lesion detection and visualization in MRI scanning, with lower doses of gadolinium compared to other agents already on the market. In March 2021, positive results from two Phase III studies comparing the diagnostic efficacy and safety of Gadopiclenol, which uses half the dose of gadolinium compared to Gadobutrol, in a wide range of indications, covering the central nervous system and various other anatomical areas (head and neck, thorax, breast, abdomen, pelvis, musculoskeletal system) were published by Guerbet. Both Guerbet and Bracco each own valuable intellectual property relating to Gadopiclenol.

Guerbet will manufacture Gadopiclenol active ingredient and vials for Bracco for up to seven years. Following a technology transfer, both companies will have the ability to manufacture the product. The first marketing authorizations are anticipated in 2023, initially in the US and the European Union (EU), with other geographies to follow.

"Gadopiclenol will be an excellent extension of Guerbet's UNIK MRI solutions of contrast media, injectors, consumables, services and software. It will enable our customers to use a lower dose of gadolinium in their everyday clinical practice. Our ambition is to make this available to as many patients as soon as possible. This is a bold decision which will accelerate our ability to further develop Gadopiclenol, which will bring significant health benefits worldwide," said CEO of Guerbet, David Hale

"Gadopiclenol represents real and valuable innovation in MRI, with a unique profile of stability and contrast enhancement properties that will allow a low dose to be effectively used in a large number of clinical settings and clinical indications," said CEO of Bracco Imaging, Fulvio Renoldi Bracco. "We are excited about this strategic addition to Bracco Imaging's MRI portfolio. Once approved, the addition of Gadopiclenol will expand our portfolio to include three different products that will help to shape the future of prevention and precision diagnostic imaging, in accordance with our global strategy."

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68 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294790954 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294790954 AND published='1' LIMIT 1

69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

70 (308.99047851562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (373.12507629395): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (51.021575927734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (49.829483032227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.133392333984): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

105 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

106 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790954 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294790954 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

109 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

110 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790954 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (504.97055053711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294790954 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (674.96299743652): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (541.92543029785): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (150.91896057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

115 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

116 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

117 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

118 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

119 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

120 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

121 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

122 (425.10032653809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790954 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790954 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 501118.89839172): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (109.91096496582): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (392.91381835938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

126 (42.200088500977): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

127 (241.04118347168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

128 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

129 (221.01402282715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

130 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

131 (515.93780517578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (364.06517028809): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (252.96211242676): SELECT name FROM jos_deeppockets WHERE id=217

134 (54.121017456055): SELECT name FROM jos_deeppockets WHERE id=217

135 (462.05520629883): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

136 (346.18377685547): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

137 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

138 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

139 (!!!!! 2099.9908447266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

142 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

143 (!!!!! 1090.0497436523): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

144 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

145 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

146 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294790954 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294790954 AND type='deeppockets_item' AND published='1' LIMIT 1

147 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

148 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

149 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

150 (136.13700866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

151 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294790954 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294790954 AND published='1' LIMIT 1

152 (70.810317993164): select jos_twitters.link from jos_twitters where cat=10

153 (25.98762512207): select jos_facebook.link from jos_facebook where cat=10

154 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

155 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

156 (285.86387634277): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

157 (!!!!! 1529.9320220947): insert into jos_banners_delta values (14615,'2025-04-30 16:05:48','3.144.112.72','view'),(14202,'2025-04-30 16:05:48','3.144.112.72','view'),(14203,'2025-04-30 16:05:48','3.144.112.72','view')

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