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Machine-Learning Algorithm Diagnoses Cancer Early and Accurately

By MedImaging International staff writers
Posted on 29 Aug 2019

Image: Researchers used synthetic images to train a machine-learning algorithm that can assist in more quickly and correctly detecting breast cancer (Photo courtesy of the University of Southern California).

A team of researchers from the University of Southern California (Los Angeles, CA, USA) used synthetic images to train a machine-learning algorithm that can assist in more quickly and correctly detecting breast cancer. The researchers first created physics-based models that showed varying levels of key properties and then used thousands of data inputs derived from those models to train the machine-learning algorithm. These kinds of techniques become important in situations where data is scarce, such as in the case of medical imaging.

The researchers used about 12,000 synthetic images to train the machine-learning algorithm. By providing enough examples, the algorithm can glean different features inherent to a benign tumor versus a malignant tumor and make the correct determination. After achieving nearly 100% classification accuracy on other synthetic images, the researchers tested the algorithm on real-world images to determine its accuracy in providing a diagnosis and measured the results against biopsy-confirmed diagnoses associated with those images. The machine-learning algorithm achieved an accuracy rate of about 80% and is now being further refined by using more real-world images as inputs.

Based on the principles used for training the machine-learning algorithm for breast cancer diagnosis, the researchers are now looking to train the algorithm to better diagnose renal cancer through contrast-enhanced CT images. The researchers believe that machine-learning algorithms are unlikely to replace a radiologist’s role in determining diagnosis, but will instead serve as a tool for guiding radiologists to reach more accurate conclusions.

“The general consensus is these types of algorithms have a significant role to play, including from imaging professionals whom it will impact the most. However, these algorithms will be most useful when they do not serve as black boxes,” said Assad Oberai, Hughes Professor in the Aerospace and Mechanical Engineering Department at the USC Viterbi School of Engineering. “What did it see that led it to the final conclusion? The algorithm must be explainable for it to work as intended.”

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72 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (59.843063354492): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

105 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

106 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

109 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

110 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (460.14785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (569.10514831543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (386.95335388184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (148.05793762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

115 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

116 (122.7855682373): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

117 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

118 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

119 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

120 (243.9022064209): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 17992.973327637): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

123 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

124 (379.80079650879): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779171 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779171 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 405472.04017639): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (72.956085205078): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (524.99771118164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (365.9725189209): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (236.03439331055): SELECT name FROM jos_deeppockets WHERE id=217

136 (33.855438232422): SELECT name FROM jos_deeppockets WHERE id=217

137 (427.0076751709): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (338.07754516602): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

140 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

141 (!!!!! 8134.126663208): TRUNCATE TABLE jos_trademed_module

142 (121.8318939209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779171 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (746.01173400879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

147 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

148 (!!!!! 1024.9614715576): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

150 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

151 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779171 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779171 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

153 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

154 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

156 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779171 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779171 AND published='1' LIMIT 1

157 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

158 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

159 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

161 (226.97448730469): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1235.9619140625): insert into jos_banners_delta values (14615,'2025-05-01 14:26:44','3.129.58.166','view'),(14202,'2025-05-01 14:26:44','3.129.58.166','view'),(14203,'2025-05-01 14:26:44','3.129.58.166','view')

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