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New Machine Learning System Aids Pathologists in Cancer Diagnoses

By MedImaging International staff writers
Posted on 22 Aug 2019

Researchers from the University of Washington (Seattle, WA, USA) and University of California (Los Angeles, CA; USA) have developed an artificial intelligence (AI) system that could help pathologists read biopsies more accurately, and lead to better detection and diagnosis of breast cancer. The new algorithm can interpret images of breast tissue biopsies to diagnose breast cancer nearly as accurately, or even better than an experienced pathologist, depending upon the task.

In 2015, a study by the UW School of Medicine found that pathologists often disagreed on the interpretation of breast biopsies, which are performed on millions of women each year. The study revealed that diagnostic errors occurred for about one out of every six women who had a non-invasive type of breast cancer called “ductal carcinoma in situ.” Additionally, incorrect diagnoses were given in about half of the biopsy cases with abnormal cells that are associated with a higher risk for breast cancer — a condition called breast atypia.

The researchers reasoned that AI could provide more accurate readings consistently as it uses a large dataset that makes it possible for the machine learning system to recognize patterns associated with cancer that are difficult for doctors to see. After studying the strategies used by pathologists during breast biopsy interpretations, the team developed image analysis methods to address these challenges. The researchers fed 240 breast biopsy images into a computer, training it to recognize patterns associated with several types of breast lesions, ranging from noncancerous and atypia to ductal carcinoma in situ and invasive breast cancer. The correct diagnoses were determined by a consensus among three expert pathologists.

The researchers then tested the system by comparing its readings with independent diagnoses made by 87 practicing US pathologists who interpreted the same cases. The algorithm came close to performing as well as the human doctors in differentiating cancer from non-cancer. However, the algorithm outperformed doctors when differentiating ductal carcinoma in situ from atypia, correctly diagnosing pre-invasive breast cancer biopsies about 89% of the time, as compared to 70% for pathologists. The researchers have already begun working on training the system to diagnose skin cancer.

“These results are very encouraging,” said the study’s co-author Dr. Joann Elmore, a professor of medicine at the David Geffen School of Medicine at UCLA, who was previously a professor of internal medicine at the UW School of Medicine. “There is low accuracy among practicing pathologists in the U.S. when it comes to the diagnosis of atypia and ductal carcinoma in situ, and the computer-based automated approach shows great promise.”

Related Links:
University of Washington
University of California

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70 (475.16822814941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (378.13186645508): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (70.095062255859): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (74.863433837891): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (87.976455688477): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (54.121017456055): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (61.03515625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (132.08389282227): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (69.141387939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (172.13821411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

105 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

106 (96.08268737793): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (84.161758422852): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

109 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

110 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (865.93627929688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (807.04689025879): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (632.04765319824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

115 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

116 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

117 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

118 (216.96090698242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

119 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

120 (400.78163146973): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 29661.178588867): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (157.11784362793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

123 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

124 (649.92904663086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779086 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779086 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 602868.7953949): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (114.91775512695): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (74.863433837891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (84.877014160156): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (67.949295043945): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (639.20021057129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (531.91184997559): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (84.877014160156): SELECT name FROM jos_deeppockets WHERE id=217

136 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=217

137 (732.1834564209): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (658.98895263672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

140 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

141 (!!!!! 14130.115509033): TRUNCATE TABLE jos_trademed_module

142 (711.20262145996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (641.82281494141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779086 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (606.06002807617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (684.02290344238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

147 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

148 (!!!!! 1722.0973968506): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

150 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

151 (77.962875366211): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779086 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779086 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (59.843063354492): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

153 (58.889389038086): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

154 (80.82389831543): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

156 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779086 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779086 AND published='1' LIMIT 1

157 (89.883804321289): select jos_twitters.link from jos_twitters where cat=10

158 (52.213668823242): select jos_facebook.link from jos_facebook where cat=10

159 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

160 (42.915344238281): select jos_linkedin.link from jos_linkedin where cat=10

161 (467.06199645996): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1529.9320220947): insert into jos_banners_delta values (14615,'2025-05-01 15:06:08','18.116.230.250','view'),(14202,'2025-05-01 15:06:08','18.116.230.250','view'),(14203,'2025-05-01 15:06:08','18.116.230.250','view')

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