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New AI System Can Diagnose and Classify Intracranial Hemorrhage

By MedImaging International staff writers
Posted on 23 Jan 2019
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Image: These images show the system’s ability to explain its diagnosis of subarachnoid (left above) and intraventricular (left below) hemorrhage by displaying images with similar appearances (right) from an atlas of images used to train the system (Photo courtesy of Hyunkwang Lee, Harvard School of Engineering and Applied Sciences, and Sehyo Yune, MD, Massachusetts General Hospital Department of Radiology).
Image: These images show the system’s ability to explain its diagnosis of subarachnoid (left above) and intraventricular (left below) hemorrhage by displaying images with similar appearances (right) from an atlas of images used to train the system (Photo courtesy of Hyunkwang Lee, Harvard School of Engineering and Applied Sciences, and Sehyo Yune, MD, Massachusetts General Hospital Department of Radiology).
Researchers from the Massachusetts General Hospital (Boston, MA, USA) have developed an artificial intelligence (AI) system that can quickly diagnose and classify brain hemorrhages, as well as provide the basis of its decisions from relatively small image datasets. The system could help hospital emergency departments in evaluating patients with symptoms of a potentially life-threatening stroke, allowing rapid application of the correct treatment.

The researchers trained the system with 904 head CT scans, each consisting of around 40 individual images, that were labeled by neuroradiologists as to whether they depicted one of five hemorrhage subtypes, based on the location within the brain, or no hemorrhage. The team improved the accuracy of the deep-learning system by building in steps mimicking the way radiologists analyze images. These included adjusting factors such as contrast and brightness to reveal subtle differences not immediately apparent and scrolling through adjacent CT scan slices to determine whether or not something that appears on a single image reflects a real problem or is a meaningless artifact.

After the model system was created, the investigators tested it on two separate sets of CT scans – a retrospective set taken before the system was developed, consisting of 100 scans with and 100 without intracranial hemorrhage, and a prospective set of 79 scans with and 117 without hemorrhage, taken after the model was created. In its analysis of the retrospective set, the model system was as accurate in detecting and classifying intracranial hemorrhages as the radiologists that had reviewed the scans had been. In its analysis of the prospective set, the system proved to be even better than non-expert human readers.

To solve the “black box” problem, or the inability of systems to explain how they arrived at a decision, the team had the system review and save the images from the training dataset that most clearly represented the classic features of each of the five hemorrhage subtypes. Using this atlas of distinguishing features, the system is able to display a group of images similar to those of the CT scan being analyzed in order to explain the basis of its decisions.

“Rapid recognition of intracranial hemorrhage, leading to prompt appropriate treatment of patients with acute stroke symptoms, can prevent or mitigate major disability or death,” said co-author Michael Lev, MD, MGH Radiology. “Many facilities do not have access to specially trained neuroradiologists – especially at night or over weekends – which can require non-expert providers to determine whether or not a hemorrhage is the cause of a patient’s symptoms. The availability of a reliable, ‘virtual second opinion’ – trained by neuroradiologists – could make those providers more efficient and confident and help ensure that patients get the right treatment.”

“In addition to providing that much needed virtual second opinion, this system also could be deployed directly onto scanners, alerting the care team to the presence of a hemorrhage and triggering appropriate further testing before the patient is even off the scanner,” added co-author Shahein Tajmir, MD, MGH Radiology. “The next step will be to deploy the system into clinical areas and further validate its performance with many more cases. We are currently building a platform to allow for the widespread application of such tools throughout the department. Once we have this running in the clinical setting, we can evaluate its impact on turnaround time, clinical accuracy and the time to diagnosis.”

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87 (364.06517028809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (85.830688476562): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (61.988830566406): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (481.12869262695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
105 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
106 (111.81831359863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 1899.0039825439): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
109 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
110 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (635.86235046387): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (991.1060333252): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (769.85359191895): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (189.06593322754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
116 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
117 (117.06352233887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
118 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
119 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
120 (458.95576477051): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121 (!!!!! 130759.0007782): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
122 (416.04042053223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
123 (213.8614654541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
124 (!!!!! 1724.0047454834): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294776566 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294776566 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 761344.90966797): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (90.122222900391): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
128 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
129 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
130 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
131 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
133 (539.06440734863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
134 (467.06199645996): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
135 (70.095062255859): SELECT name FROM jos_deeppockets WHERE id=217
136 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=217
137 (695.94383239746): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
138 (618.93463134766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
139 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
140 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
141 (!!!!! 9268.9990997314): TRUNCATE TABLE jos_trademed_module
142 (110.14938354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
143 (57.220458984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294776566 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
144 (!!!!! 1065.0157928467): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
147 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
148 (!!!!! 1350.1644134521): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
149 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
150 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
151 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294776566 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294776566 AND type='deeppockets_item' AND published='1' LIMIT 1
152 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)
153 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)
154 (43.153762817383): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155 (247.95532226562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
156 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294776566 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294776566 AND published='1' LIMIT 1
157 (64.13459777832): select jos_twitters.link from jos_twitters where cat=10
158 (42.200088500977): select jos_facebook.link from jos_facebook where cat=10
159 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10
160 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10
161 (329.01763916016): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
162 (!!!!! 1498.9376068115): insert into jos_banners_delta values (14615,'2025-05-02 09:15:04','3.145.2.74','view'),(14202,'2025-05-02 09:15:04','3.145.2.74','view'),(14203,'2025-05-02 09:15:04','3.145.2.74','view')