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New All-Optical System Could Revolutionize Image-Guided Interventions

By MedImaging International staff writers
Posted on 29 Aug 2018

Image: All-optical ultrasound imager. This prototype is the first all-optical ultrasound imager to demonstrate video-rate, real-time 2D imaging of biological tissue. The achievement is an important step toward making all-optical ultrasound practical for routine clinical use, where it could offer significant advantages over current imaging technology (Photo courtesy of Erwin J. Alles, University College London).

A new ultrasound system that uses optical, instead of electronic components, could improve performance while providing doctors with significantly more flexibility in the way they use ultrasound to diagnose and treat medical problems. For the first time, researchers have demonstrated the use of an all-optical ultrasound imager for video-rate, real-time 2D imaging of biological tissue, marking a significant step towards making all-optical ultrasound practical for routine clinical use. Since all-optical ultrasound systems do not require any electronic components in the imaging probe, they could be safely used at the same time as magnetic resonance imaging (MRI) scanners. This can provide doctors with a more comprehensive picture of the tissues around an area of interest, such as a tumor or blood vessel, according to a recent paper published in the Optical Society (OSA) journal Biomedical Optics Express.

Conventional ultrasound imagers use arrays of electronic transducers to transmit high-frequency sound waves into tissue and receive the reflections, whereas all-optical ultrasound imagers use light to both transmit and receive ultrasound waves. Pulsed laser light is used to generate ultrasound waves, and scanning mirrors control where the waves are transmitted into the tissue. A fiber optic sensor then receives the reflected waves.

The researchers demonstrated how the light source can be manipulated to generate either low frequency ultrasound, resulting in greater penetration into the tissue, or high frequency ultrasound, which offers higher resolution images at a shallower depth. The team tested their prototype system by imaging a deceased zebrafish and a pig artery that was manipulated to emulate the dynamics of pulsing blood. The demonstration showed imaging capabilities comparable to an electronic high-frequency ultrasound system, with a sustained frame rate of 15 Hertz, a dynamic range of 30 decibels, a penetration depth of 6 millimeters and a resolution of 75 by 100 micrometers.

The researchers are now working to adapt the technology for clinical use by developing a long, flexible imaging probe for free-hand operation, as well as miniaturized versions for endoscopic applications. In conventional ultrasound devices, the electronic components make it difficult to miniaturize the devices for internal use. On the other hand, optical components are easily miniaturized and tiny all-optical ultrasound probes are likely be significantly less expensive to manufacture as compared to compact electronic ultrasound systems, according to the researchers.

“All-optical ultrasound imaging probes have the potential to revolutionize image-guided interventions,” said Erwin J. Alles, University College London. “A lack of electronics and the resulting MRI compatibility will allow for true multimodality image guidance, with probes that are potentially just a fraction of the cost of conventional electronic counterparts.”

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68 (72.002410888672): SELECT fid FROM jos_deeppockets WHERE id=294774650 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774650 AND published='1' LIMIT 1

69 (417.94776916504): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

70 (292.06275939941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1278.1620025635): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (911.95106506348): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 2497.9114532471): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (243.9022064209): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (450.13427734375): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (88.930130004883): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

105 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

106 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (105.14259338379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

109 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

110 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (581.97975158691): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (550.98533630371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1808.8817596436): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (224.11346435547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

115 (205.99365234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

116 (169.99244689941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

117 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

118 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

119 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

120 (406.02684020996): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 75029.850006104): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

123 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

124 (!!!!! 1413.8221740723): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774650 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774650 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1719740.8676147): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (101.08947753906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (77.962875366211): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (669.00253295898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (600.09956359863): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (335.9317779541): SELECT name FROM jos_deeppockets WHERE id=217

136 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=217

137 (699.99694824219): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (608.92105102539): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

140 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

141 (!!!!! 11790.037155151): TRUNCATE TABLE jos_trademed_module

142 (136.13700866699): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (168.0850982666): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774650 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 2350.0919342041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

147 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

148 (!!!!! 1616.0011291504): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

150 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

151 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774650 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774650 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (684.02290344238): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

153 (110.14938354492): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

154 (60.081481933594): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (!!!!! 1502.0370483398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

156 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774650 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774650 AND published='1' LIMIT 1

157 (65.088272094727): select jos_twitters.link from jos_twitters where cat=10

158 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

159 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

160 (46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10

161 (356.91261291504): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1688.0035400391): insert into jos_banners_delta values (14615,'2025-06-18 01:18:01','216.73.216.120','view'),(14202,'2025-06-18 01:18:01','216.73.216.120','view'),(14203,'2025-06-18 01:18:01','216.73.216.120','view')

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