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Machine-Learning Algorithm Analyzes Images to Identify Schizophrenia Patients

By MedImaging International staff writers
Posted on 31 Jul 2018

A team of researchers from the University of Alberta (Edmonton, Alberta, Canada) has developed a machine-learning algorithm to examine functional magnetic resonance imaging (fMRI) images for identifying patients suffering from schizophrenia and ascertaining if they would respond to treatment. More...

In a study, the algorithm examined MRI images of both newly diagnosed, previously untreated schizophrenia patients and healthy subjects and successfully identified patients with schizophrenia at 78% accuracy. It also predicted whether or not a patient would respond positively to a specific antipsychotic treatment named risperidone with 82% accuracy.

Schizophrenia, a severe and disabling psychiatric disorder that comes with delusions, hallucinations and cognitive impairments, affects approximately one in 100 people at some point in their lives. Early diagnosis of schizophrenia and other mental disorders still remains a challenge, while clinicians face the difficult task of devising a personalized treatment strategy during the first visit with a patient. Currently, the treatment of schizophrenia is usually determined using a trial-and-error style. However, if a drug does not work properly, the patient can suffer prolonged symptoms and side effects, and miss the best time window to control and treat the disease.

The initial trial results of the machine-learning algorithm for the diagnosis and treatment of schizophrenia have been encouraging. However, further validations on large samples will be required and more refinement is needed to improve its accuracy before using it in a clinical environment. The researchers also expect to expand their work to include other mental illness such as major depressive and bipolar disorders.

"This is the first step, but ultimately we hope to find reliable biomarkers that can predict schizophrenia before the symptoms show up," said Bo Cao, an assistant professor of psychiatry at the University of Alberta, who led the research. "We also want to use machine learning to optimize a patient's treatment plan. It wouldn't replace the doctor. In the future, with the help of machine learning, if the doctor can select the best medicine or procedure for a specific patient at the first visit, it would be a good step forward."

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University of Alberta

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63 (84.877014160156): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (577.92663574219): SELECT fid FROM jos_deeppockets WHERE id=294774300 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774300 AND published='1' LIMIT 1

65 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

66 (45.061111450195): select jos_twitters.link from jos_twitters where cat=10

67 (29.802322387695): select jos_facebook.link from jos_facebook where cat=10

68 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

69 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

70 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294774300 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294774300 AND published='1' LIMIT 1

71 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

72 (271.08192443848): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (201.94053649902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (43.153762817383): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

107 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

108 (48.160552978516): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

111 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

112 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (583.88710021973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (521.89826965332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (308.03680419922): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

116 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

117 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

118 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

119 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

121 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

122 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

123 (34.093856811523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

124 (257.01522827148): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 18708.944320679): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (488.9965057373): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774300 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774300 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 7009.9830627441): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (67.949295043945): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

131 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

133 (267.98248291016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (86.069107055664): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

135 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

137 (496.14906311035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (369.07196044922): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (38.14697265625): SELECT name FROM jos_deeppockets WHERE id=217

140 (27.894973754883): SELECT name FROM jos_deeppockets WHERE id=217

141 (527.85873413086): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (423.19297790527): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

144 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

145 (!!!!! 7282.018661499): TRUNCATE TABLE jos_trademed_module

146 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294774300 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (764.13154602051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

151 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

152 (!!!!! 1158.9527130127): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

154 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

155 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294774300 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294774300 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (28.848648071289): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

157 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

158 (29.087066650391): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

160 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294774300 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294774300 AND published='1' LIMIT 1

161 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

162 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

163 (43.153762817383): select jos_google_plus.link from jos_google_plus where cat=10

164 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

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