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Collaboration in Singapore to Develop in vivo Molecular Imaging Agent

By MedImaging International staff writers
Posted on 24 Jun 2014

A new partnership for the establishment of an imaging research laboratory based in Singapore will focus on developing biomarkers for the study of diseases such as cancer and immune dysregulation.

ImaginAb (Inglewood, CA, USA), and Duke-National University Singapore (NUS) Graduate Medical School will partner to develop in vivo molecular imaging agents focused on cancer, immunology, and disease areas unique to the Asian region.

Duke-NUS Medical School is a Singapore-based venture between Duke University (Durham, NC, USA) and the National University of Singapore, a US-style medical school that is focused on training scientists and researchers targeted to biosciences discoveries and development for Singapore’s biomedical research hub.

The USD 12 million collaboration between ImaginAb and Duke-NUS has resulted in a joint corporate laboratory to develop new in vivo molecular imaging agents with an Asian disease-centric focus. The parties have earlier reported the establishment of protein engineering and molecular imaging capabilities designed to interface with Duke-NUS’s Signature Research Programs (SRPs) in cancer and stem cell biology, cardiovascular, and metabolic diseases, neuroscience, and immunology. These new capabilities will also be used to support ImaginAb’s internal R&D activities and serve as a focal point for several of ImaginAb’s key collaborations in cancer and immunology.

Called the Imaging Biomarker Development Lab (IBDL), the joint laboratory is the latest initiative under the National Research Foundation (NRF) Corp Lab @ University scheme. The IBDL program represents a USD 15 million commitment between ImaginAb, Duke-NUS and the NRF. The laboratory is available to industry and academic collaborators with the goal of developing precision medicine applications for healthcare.

“We are pleased to have this new capability on-line and to have recruited the initial team that will launch this exciting new translational research opportunity,” noted Prof. Patrick Casey, senior vice dean, research, of Duke-NUS Graduate Medical School. “It is particularly important that, in addition to our collaborations with ImaginAb and internal use of the facility, we send a message to our academic and industry collaborators that this capability is available,” he added.

The IBDL will incorporate several specialty core facilities designed to operate in an integrated fashion with Duke-NUS’ existing research services. Furthermore, the IBDL will feature a state-of-the-art molecular imaging facility, operating within Duke-NUS’s specific pathogen-free (SPF) space, a vital resource for immunology-based research.

The new lab was formally launched June 5, 2014, in a public ceremony at the Singapore ArtScience Museum, with Philip Yeo (chairman of SPRING), presiding. Mr. Yeo, chairman of SPRING, commented, “Part of building an effective biomedical ecosystem in Singapore is not just the engagement of global pharmaceutical companies and best-in-class researchers, but the high-growth and high-innovation segments of industry. Singapore has the potential to be a leading “hot spot” in life sciences and biotechnology but this will only happen if we are also able to recruit, and ultimately develop, high-growth firms that can harness Singapore’s entrepreneurial mindset.”

ImaginAb is taking a new approach to diagnostic imaging agents, relying on developing antibodies into smaller protein fragments that zero in on their targets during a PET scan, visualizing a tumor or disease on the molecular level.

Duke-NUS has been involved in diagnostics research before. In 2013, for example, Lim Soon Thye, a researcher from the school and the National Cancer Center Singapore, was part of a group of investigators that developed a diagnostic test to help target and treat a new type of deadly intestinal lymphoma common in Asia.

ImaginAb reported that it would use its new venture funds to expand its pipeline of in vivo imaging agents.

Related Links:
ImaginAb
Duke-National University Singapore

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59 (!!!!! 3024.1012573242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

60 (!!!!! 2200.1266479492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

61 (765.08522033691): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (735.04447937012): SELECT fid FROM jos_deeppockets WHERE id=294753186 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753186 AND published='1' LIMIT 1

63 (434.87548828125): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

64 (283.95652770996): select jos_twitters.link from jos_twitters where cat=10

65 (76.055526733398): select jos_facebook.link from jos_facebook where cat=10

66 (117.06352233887): select jos_google_plus.link from jos_google_plus where cat=10

67 (513.07678222656): select jos_linkedin.link from jos_linkedin where cat=10

68 (288.00964355469): SELECT fid FROM jos_deeppockets WHERE id=294753186 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753186 AND published='1' LIMIT 1

69 (291.10908508301): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

70 (193.11904907227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 2905.8456420898): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (62.942504882812): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (60.796737670898): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (143.05114746094): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 1559.0190887451): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (630.14030456543): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (150.20370483398): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 6381.9885253906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

105 (!!!!! 4878.9978027344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

106 (68.187713623047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (535.01129150391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

110 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (650.88272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (866.17469787598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (467.06199645996): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (385.04600524902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

115 (166.89300537109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

116 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

117 (364.06517028809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

118 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

119 (682.83081054688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

120 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

121 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

122 (334.02442932129): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 42502.880096436): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (905.99060058594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753186 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753186 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 20501.852035522): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (52.928924560547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (687.1223449707): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (279.90341186523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (363.11149597168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (333.07075500488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (422.95455932617): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (459.90943908691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (342.13066101074): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (667.09518432617): SELECT name FROM jos_deeppockets WHERE id=217

138 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=217

139 (567.91305541992): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (423.19297790527): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

142 (623.94142150879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

143 (!!!!! 23600.101470947): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1004.9343109131): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (239.13383483887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753186 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (406.02684020996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (305.17578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

150 (!!!!! 7880.9261322021): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 7725.9540557861): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

152 (!!!!! 7984.1613769531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

153 (!!!!! 5896.8067169189): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753186 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753186 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (961.0652923584): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

155 (55.074691772461): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

156 (168.0850982666): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (372.88665771484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

158 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753186 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753186 AND published='1' LIMIT 1

159 (277.04238891602): select jos_twitters.link from jos_twitters where cat=10

160 (36.001205444336): select jos_facebook.link from jos_facebook where cat=10

161 (241.99485778809): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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