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Targeted MRI to Transform Imaging Market

By MedImaging International staff writers
Posted on 17 Nov 2010

Targeted magnetic resonance imaging (MRI), a technology in development that would reveal specific disease indicators present in a patient to clinicians at the molecular level, would considerably improve demand for imaging procedures, according to recent healthcare market research.

In a recent report, Kalorama Information (New York, NY, USA), a publisher of healthcare market research, found that if the type of targeted agents now available for single photon emission computed tomography (SPECT) training were applied to MRI and ultrasound in a clinical setting, the world market for contrast agents would see a dramatic increase.

"The development of targeted MRI contrast agents that are directed to specific molecular entities could dramatically expand the range of MRI market applications by combining the noninvasiveness and high spatial resolution of MRI with the specific localization of molecular targets,” said Joe Constance, Kalorama analyst and author of the report. "The technologies have the potential to make imaging definitive for a range of clinical applications such as the detection of tumors and heart disease.”

Targeted imaging involves adding special molecules to imaging agents that can attach directly to specific molecular entities. The application combines the effectiveness of a contrast agent with an adhesion molecule in order to target the contrast directly to the desired target. The imaging approach differs depending on whether the target is a single disease control point (a specific receptor or transport protein tied to the mechanistic activity of a drug) or a general disease control point applicable to a number of treatment paradigms (proliferation, angiogenesis, or inflammation).

Currently, there are no targeted MRI contrast agents available for specific imaging of tumor and cardiovascular diseases, but many MRI applications are under development, according to the report. However, several targeted SPECT imaging agents are available for clinical applications. Because of the fundamentally low sensitivity of MRI, in comparison with nuclear imaging, high concentrations of the contrast agent at the target site would be required, along with high affinity and specificity of cell recognition.

Scientists have successfully targeted MRI and nuclear medicine contrast agents to the alpha-V/beta 3 integrin, permitting noninvasive monitoring of angiogenesis.

In some instances, the targeted approach may require the use of less contrast. Differential contrast in soft tissues depends on endogenous differences in water content, relaxation times, or the diffusion characteristics of the tissue of interest. Gadolinium chelates, for example, have been successfully used for imaging hemodynamic parameters, including blood perfusion and vascular permeability.

Kalorama estimated the 2010 market for all contrast media at over US$7.5 billion. The firm sees realistic growth rates based on existing market conditions, but noted that a trend such as targeting agents could considerably increase revenue potential for companies in this industry.

Kalorama Information supplies independent market research in the life sciences, as well as a full range of custom research services.

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63 (!!!!! 6309.986114502): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

64 (!!!!! 7540.9412384033): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 7922.887802124): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 7942.1997070312): select jos_google_plus.link from jos_google_plus where cat=10

67 (!!!!! 7956.9816589355): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 5445.0035095215): SELECT fid FROM jos_deeppockets WHERE id=294732081 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294732081 AND published='1' LIMIT 1

69 (!!!!! 6256.103515625): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

70 (!!!!! 7653.9516448975): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 7912.1589660645): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 7812.0231628418): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (474.92980957031): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (129.93812561035): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (141.85905456543): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (122.0703125): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (133.03756713867): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (124.21607971191): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (142.09747314453): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (149.01161193848): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 1338.9587402344): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (186.92016601562): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (314.95094299316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (139.95170593262): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (631.09397888184): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1107.931137085): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (123.97766113281): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (602.96058654785): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (147.10426330566): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (232.93495178223): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (131.84547424316): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (270.84350585938): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (812.05368041992): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (159.97886657715): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (147.10426330566): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2135.0383758545): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

105 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

106 (725.98457336426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (602.00691223145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2775.9075164795): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

109 (674.96299743652): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

110 (!!!!! 4688.9781951904): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (563.8599395752): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1094.1028594971): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (462.05520629883): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1359.9395751953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

115 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

116 (977.99301147461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

117 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

118 (!!!!! 1296.0433959961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

119 (213.8614654541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

120 (!!!!! 1260.0421905518): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

121 (715.97099304199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

122 (!!!!! 1703.0239105225): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 47312.021255493): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 5577.0874023438): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732081 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732081 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (801.08642578125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (244.8558807373): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (484.94338989258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (111.10305786133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (787.01972961426): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (258.20732116699): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (212.9077911377): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (371.93298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (757.93266296387): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (451.80320739746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (!!!!! 1203.0601501465): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 1620.0542449951): SELECT name FROM jos_deeppockets WHERE id=217

138 (!!!!! 4992.9618835449): SELECT name FROM jos_deeppockets WHERE id=217

139 (!!!!! 1543.9987182617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 5215.1679992676): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 4858.9706420898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

142 (785.82763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

143 (!!!!! 10900.974273682): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 4775.0473022461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 1481.0562133789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732081 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (989.91394042969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (329.97131347656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 1838.9225006104): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

149 (!!!!! 1655.101776123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

150 (!!!!! 1768.8274383545): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 10362.148284912): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

152 (!!!!! 3217.9355621338): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

153 (185.96649169922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732081 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732081 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (753.87954711914): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

155 (519.99092102051): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

156 (916.95785522461): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 1869.9169158936): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

158 (537.87231445312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732081 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732081 AND published='1' LIMIT 1

159 (!!!!! 1929.9983978271): select jos_twitters.link from jos_twitters where cat=10

160 (45.061111450195): select jos_facebook.link from jos_facebook where cat=10

161 (407.93418884277): select jos_google_plus.link from jos_google_plus where cat=10

162 (44.107437133789): select jos_linkedin.link from jos_linkedin where cat=10

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