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Companies Collaborate on Nuclear Medicine Therapy for Neuroendocrine Tumors

By HospiMedica staff writers
Posted on 15 Nov 2007

Covidien, Ltd. (St. Louis, MO, USA) and BioSynthema, Inc. (St. Louis, MO, USA) have signed an agreement to develop and commercialize a nuclear medicine therapy for neuroendocrine cancer patients.

Under the terms of an exclusive license agreement, BioSynthema will gain access to specific Covidien proprietary peptide technology. The license will enable BioSynthema to use this technology in conjunction with its own technology and proprietary clinical research to further develop a new targeted-radionuclide therapy product. Under the terms of a separate agreement, Covidien will have exclusive marketing rights to the resulting cancer therapy technology.

"We are very pleased to be working with BioSynthema on this important technology,” said Steve Hanley, president of Covidien Imaging Solutions. "This project reflects Covidien's commitment to the future of nuclear medicine and to the development of new and unique radiolabeled products.”

The new technology utilizes a radiolabeled peptide that targets specific somatostatin receptors on neuroendocrine cancer cells. If approved, this drug candidate will add to Covidien's range of nuclear medicine oncology agents, including OctreoScan (kit for the preparation of indium In-111 pentetreotide), a molecular imaging agent that is indicated for the scintigraphic detection and localization of primary and metastatic neuroendocrine tumors bearing somatostatin receptors. The safety and effectiveness of OctreoScan imaging agent in pediatric patients have not been established, and use in patients with impaired renal function should be carefully considered.

Covidien Imaging Solutions is a provider of imaging products used by physicians to detect and diagnose various diseases. BioSynthema is a drug discovery and development company focusing on unique pharmaceuticals that target cell surface receptors overexpressed in cancer cells.

Using this technology, BioSynthema has collaborated with Eric Krenning, M.D., Ph.D., FRCP, and professor of nuclear medicine at the Erasmus Medical Centre (Rotterdam, The Netherlands), for more than five years on a clinical therapy study, which has enrolled over 600 patients. "I am very encouraged that Covidien and BioSynthema have agreed to cooperate in the development and commercialization of this product,” said Prof. Krenning.

"The incidence of neuroendocrine tumors is approximately 20,000 new cases per year in the U.S. and Europe,” said Jack Erion, Ph.D., president and CEO of BioSynthema. "If approved, this technology would provide a new therapeutic drug for those patients who currently have very limited treatment options.”

Under the terms of the agreements, BioSynthema will develop and manufacture the product and Covidien will be responsible for worldwide marketing, sales, and distribution. The companies plan to pursue marketing authorization in Europe and the United States initially.

Related Links:
Covidien
BioSynthema

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58 (613.92784118652): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1612.9016876221): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

60 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

61 (178.09867858887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

62 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

63 (130.17654418945): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (694.99015808105): SELECT fid FROM jos_deeppockets WHERE id=262280000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=262280000 AND published='1' LIMIT 1

65 (58.174133300781): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

66 (90.122222900391): select jos_twitters.link from jos_twitters where cat=10

67 (51.021575927734): select jos_facebook.link from jos_facebook where cat=10

68 (49.829483032227): select jos_google_plus.link from jos_google_plus where cat=10

69 (45.7763671875): select jos_linkedin.link from jos_linkedin where cat=10

70 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE id=262280000 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=262280000 AND published='1' LIMIT 1

71 (64.13459777832): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

72 (386.95335388184): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (245.80955505371): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (54.836273193359): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (79.154968261719): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (144.00482177734): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (85.115432739258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (84.877014160156): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (49.829483032227): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

107 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

108 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

111 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

112 (493.04962158203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (416.04042053223): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (63.180923461914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=262260000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (375.03242492676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=262260000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (792.9801940918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (586.03286743164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (174.99923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

119 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

120 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

122 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

123 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

124 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

125 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

126 (327.11029052734): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 19833.087921143): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (607.96737670898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=262280000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=262280000 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 8076.9062042236): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (86.069107055664): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (49.829483032227): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (60.796737670898): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (371.93298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (71.048736572266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (550.98533630371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (413.89465332031): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (47.922134399414): SELECT name FROM jos_deeppockets WHERE id=217

142 (59.127807617188): SELECT name FROM jos_deeppockets WHERE id=217

143 (689.98336791992): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (554.08477783203): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

146 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

147 (!!!!! 9592.0562744141): TRUNCATE TABLE jos_trademed_module

148 (144.00482177734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=262280000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (597.00012207031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

153 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

154 (!!!!! 1155.1380157471): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

156 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

157 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=262280000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=262280000 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (369.07196044922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

162 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=262280000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=262280000 AND published='1' LIMIT 1

163 (41.007995605469): select jos_twitters.link from jos_twitters where cat=10

164 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

165 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

166 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

167 (277.99606323242): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14202,14203)

168 (!!!!! 1041.8891906738): insert into jos_banners_delta values (14202,'2025-08-19 22:35:23','216.73.216.0','view'),(14203,'2025-08-19 22:35:23','216.73.216.0','view')

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