Radiotherapy Advances Presented at Research Summit

By MedImaging staff writers
Posted on 16 Mar 2006

Varian Medical Systems (Palo Alto, CA, USA) gathered over 100 radiation oncology researchers for a Research Partnership Summit in early February 2006. The two-and-a-half-day gathering, held in Charleston, SC, USA, brought together physicists, biologists, veterinarians, and physicians who are conducting Varian-funded research.

"These presentations incorporate data that is only days or weeks old. It's an amazing snapshot of where the technology is at this point in time, for people who are really pushing the envelope,” commented Frank Bova, Ph.D., professor of neurosurgery at the University of Florida (Gainesville, FL, USA), who moderated a session on stereotactic radiosurgery, a procedure that involves treating a malignancy or neurological malformation with a carefully targeted single dose of radiation.

Other presentations covered product strategies for dealing with tumor motion during treatment, including the use of respiratory gating and other 4D imaging procedures and software that track and compensate for tumor motion caused by breathing.

Paul Keall, Ph.D., associate professor of medical physics at Virginia Commonwealth University provided a look at technology in development that can locate and track a tumor and adjust the treatment beam in direct response to internal or skeletal motion. Such a "dynamic compensation” approach would enable treatments that respond to tumor motion in real time by shaping and reshaping the radiation beams--something that is not yet possible in a commercially-available radiotherapy system.

Researchers also presented on projects involving biosynergy, ways in which biologically active agents can be used to enhance the clinical effects of radiation. Scientists from a number of U.S. colleges also presented data on compounds that make tumor cells more responsive to radiation, substances that protect normal tissues from the effects of radiation, and biomarkers that can be used to generate functional images with detailed information about tumor metabolism.

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69 (37.908554077148): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=217 ORDER BY `ordering`

70 (668.04885864258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1831.0546875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (328.77922058105): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 6711.9598388672): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (78.916549682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (361.20414733887): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (303.03001403809): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (302.79159545898): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (277.04238891602): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1151.0848999023): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (289.9169921875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (66.995620727539): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (907.89794921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (226.02081298828): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (472.06878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (369.07196044922): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (481.84394836426): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (971.07887268066): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (232.93495178223): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1349.925994873): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (283.95652770996): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1415.0142669678): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

105 (261.78359985352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

106 (120.16296386719): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (661.13471984863): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3307.8193664551): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

109 (!!!!! 1082.8971862793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

110 (!!!!! 1466.0358428955): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1533.9851379395): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (629.90188598633): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (856.16111755371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (433.20655822754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

115 (!!!!! 1936.1972808838): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

116 (804.90112304688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

117 (186.92016601562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

118 (190.97328186035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

119 (274.1813659668): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

120 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

121 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

122 (406.98051452637): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 55888.175964355): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1460.075378418): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=182100000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=182100000 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (54.836273193359): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (47.922134399414): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (486.13548278809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (751.97219848633): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 1326.7993927002): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (252.00843811035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (403.16581726074): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (582.93342590332): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (437.97492980957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (591.99333190918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (501.15585327148): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (66.041946411133): SELECT name FROM jos_deeppockets WHERE id=217

138 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=217

139 (846.14753723145): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (731.9450378418): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))217((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

142 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

143 (!!!!! 31449.07951355): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 6989.9559020996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 7692.0986175537): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=182100000 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 4132.9860687256): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 7753.1337738037): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 7442.9512023926): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

149 (!!!!! 8342.0276641846): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

150 (!!!!! 7705.9268951416): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 7673.0251312256): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

152 (!!!!! 7973.1941223145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

153 (!!!!! 7494.2111968994): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=182100000 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=182100000 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 12124.061584473): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

155 (!!!!! 7915.0199890137): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=217 or channel_id is null)

156 (!!!!! 7797.9564666748): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 7049.0837097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

158 (!!!!! 5735.8741760254): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=182100000 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=182100000 AND published='1' LIMIT 1

159 (65.088272094727): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 1424.0741729736): select jos_facebook.link from jos_facebook where cat=10

161 (48.160552978516): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

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