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3D Modeling System Accurately Predicts Pediatric Donor Heart Volumes

By MedImaging International staff writers
Posted on 24 Nov 2015

Image: 3D scan a child’s heart born with congenital heart defects (Photo courtesy of the Phoenix Children’s Hospital).

A new three dimensional (3D) computer modeling system may more accurately identify the best donor heart for a pediatric transplant patient.

To develop the new 3D system, researchers at Arizona State University (ASU; Tempe, USA) and Phoenix Children’s Hospital (AZ, USA) first created a library of 3D reconstructed hearts in healthy children weighing up to 45 kilograms, using magnetic resonance imaging (MRI) and computerized tomography (CT) scans. They then used the virtual library to predict the best donor body weight/heart size correlation needed for pediatric transplant recipients. Concomitantly, they examined before and after images from infants who had already received a heart transplant.

When the researchers compared the post-operative data from the real infants with the virtual transplant images, they found that the 3D imaging system accurately identified an appropriate size heart, validating their findings. The researchers are currently expanding the virtual library to improve prognostic capabilities, thus allowing more effective organ allocation and minimizing the number of otherwise acceptable organs that are ultimately discarded. The study was presented at the annual American Heart Association (AHA) Scientific Sessions, held during November 2015 in Orlando (FL, USA).

“It is critical to optimize the range of acceptable donors for each child. 3D reconstruction has tremendous potential to improve donor size matching,” said lead author and study presenter Jonathan Plasencia, BSc, of the ASU image processing applications lab. “We feel that we now have evidence that 3D matching can improve selection and hope this will soon help transplant doctors, patients, and their parents make the best decision by taking some of the uncertainty out of this difficult situation.”

“Analyzing future transplant cases using 3D matching will allow us to predict the true upper and lower limits of acceptable donor size. The big question is how long it will take to further test the technique and move it into actual use,” concluded Mr. Plasencia, who is a PhD student at ASU. “One day transplant teams may be able to use the 3D process to perform virtual transplants before an actual procedure to rapidly measure a donated heart to ensure a better fit and to reduce the risk of mismatching in pediatric transplants.”

Transplant centers currently assess compatibility of a potential donor heart by comparing the donor weight to the recipient weight, and then picking an upper and lower limit based on the size of the patient’s heart on chest X-ray. But the assessment is not precise and variations in size and volume can have a major effect on the recipient’s outcome.

Related Links:
Arizona State University
Phoenix Children’s Hospital

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67 (!!!!! 2643.8236236572): select jos_linkedin.link from jos_linkedin where cat=10

68 (80.82389831543): SELECT fid FROM jos_deeppockets WHERE id=294761475 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294761475 AND published='1' LIMIT 1

69 (50.067901611328): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

70 (605.10635375977): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (447.98851013184): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (72.956085205078): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (988.00659179688): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (454.18739318848): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (176.90658569336): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (98.943710327148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (121.8318939209): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (340.93856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 2547.025680542): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (412.94097900391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (135.89859008789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (174.99923706055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 1147.985458374): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (154.01840209961): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (288.00964355469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (278.94973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 1008.0337524414): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (185.01281738281): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (639.91546630859): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (498.05641174316): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1463.8900756836): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

105 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

106 (144.95849609375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (826.83563232422): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2525.0911712646): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

109 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

110 (311.85150146484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (768.18466186523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (835.89553833008): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (425.81558227539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (185.01281738281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

115 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

116 (207.90100097656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

117 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

118 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

120 (!!!!! 1100.0633239746): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 165223.12164307): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

123 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

124 (!!!!! 6736.9937896729): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761475 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761475 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1027179.0027618): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (487.8044128418): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1306.0569763184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (318.05038452148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (!!!!! 1043.7965393066): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (!!!!! 1776.9336700439): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (!!!!! 6285.1905822754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (69.141387939453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (513.07678222656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (!!!!! 4925.012588501): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (!!!!! 10236.978530884): SELECT name FROM jos_deeppockets WHERE id=216

136 (!!!!! 1200.9143829346): SELECT name FROM jos_deeppockets WHERE id=216

137 (!!!!! 4268.8846588135): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (!!!!! 4534.9597930908): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1552.1049499512): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

140 (!!!!! 3844.0227508545): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

141 (!!!!! 26096.820831299): TRUNCATE TABLE jos_trademed_module

142 (713.10997009277): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (!!!!! 1558.0654144287): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294761475 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (436.06758117676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (203.13262939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

147 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

148 (!!!!! 1632.9288482666): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (843.04809570312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

150 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

151 (123.02398681641): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761475 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761475 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (53.167343139648): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

153 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

154 (68.187713623047): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

156 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761475 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761475 AND published='1' LIMIT 1

157 (706.91108703613): select jos_twitters.link from jos_twitters where cat=10

158 (51.021575927734): select jos_facebook.link from jos_facebook where cat=10

159 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

160 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

161 (418.18618774414): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 3207.9219818115): insert into jos_banners_delta values (14615,'2025-04-30 18:50:05','3.138.113.73','view'),(14202,'2025-04-30 18:50:05','3.138.113.73','view'),(14203,'2025-04-30 18:50:05','3.138.113.73','view')

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