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Hidden Data Behind Imaging Scans for Cancer May offer New Radiotherapy Strategies

By MedImaging International staff writers
Posted on 30 Jul 2014

Information hidden in imaging tests could help clinicians more effectively choose the radiation therapy dose needed to kill tumors, suggests a study of more than 300 cancer patients.

The research, to be presented at the 56th annual meeting of the American Association of Physicists in Medicine (AAPM), held during July 28 to August 1, 2014, in Austin, TX, USA, is the largest study to date to use radiomics—extracting statistical data from images and other measurements—to help predict the probable progression of cancer or its response to treatment based on positron emission tomography (PET) imaging scans of patients with non-small-cell lung cancer and head and neck cancer.

“Currently, there is a one-size-fits-all process for selecting radiation therapy doses, which might be too much for some patients and not enough for others,” said Joseph Deasy, PhD, senior author of the study and chair of the department of medical physics at Memorial Sloan-Kettering Cancer Center (New York, NY, USA). “Radiomics will help us know when we can turn down the treatment intensity with confidence, knowing we can still control the disease.”

In the study, researchers performed PET scanning in 163 non-small-cell lung cancer patients and 174 head and neck cancer patients before and after treatment. They extracted a range of information from each tumor, including the intensity value of the PET image, the roughness of the image, and other information, such as how round the tumor was. In PET, the brighter an area is, the higher the intensity, revealing that the tumor is consuming a greater amount of energy from the injected radioactive glucose substitute tracer.

Comparing the data gathered from the before and after scans to how the patient fared—including whether the tumor shrank or how long the patient survived—researchers can create models that will help direct future therapy. In this study, for instance, researchers determined that lung tumors that have a higher uptake of the tracer need to be treated with a higher dose of radiation than is typically prescribed.

“Standard protocol today is to only use PET imaging to define the extent of a tumor to be treated,” said Dr. Deasy. “Based on the information from this study, the data would be extracted from those images and put into models that would tell the physician what dose was required to kill the tumor with a high probability.” He noted that radiomics is a team effort that requires good collaboration between physicians, physicists, and computer scientists.

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69 (47.922134399414): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

70 (396.9669342041): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (325.91819763184): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (55.074691772461): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (102.04315185547): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (47.922134399414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (68.187713623047): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

105 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

106 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (64.849853515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

109 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

110 (52.213668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (580.0724029541): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (550.0316619873): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (420.09353637695): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

115 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

116 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

117 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

118 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

119 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

120 (371.93298339844): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 26169.061660767): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

123 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

124 (516.89147949219): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753733 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753733 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 472517.96722412): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (164.98565673828): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (118.97087097168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (66.995620727539): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (665.90309143066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (536.91864013672): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (357.15103149414): SELECT name FROM jos_deeppockets WHERE id=216

136 (48.160552978516): SELECT name FROM jos_deeppockets WHERE id=216

137 (840.90232849121): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (603.19900512695): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

140 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

141 (!!!!! 12611.150741577): TRUNCATE TABLE jos_trademed_module

142 (116.82510375977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (231.98127746582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (581.02607727051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

147 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

148 (!!!!! 1548.0518341064): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

150 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

151 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753733 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753733 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (554.08477783203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

153 (103.95050048828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

154 (84.877014160156): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

156 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753733 AND published='1' LIMIT 1

157 (46.014785766602): select jos_twitters.link from jos_twitters where cat=10

158 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

159 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

160 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

161 (322.81875610352): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 2753.0193328857): insert into jos_banners_delta values (14615,'2025-05-02 07:20:58','52.14.154.79','view'),(14202,'2025-05-02 07:20:58','52.14.154.79','view'),(14203,'2025-05-02 07:20:58','52.14.154.79','view')

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