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Market Agreement Established for Next-Generation Software to Enable MRI-Guided, Catheter-Based Procedures

By MedImaging International staff writers
Posted on 03 Mar 2014

MRI Interventions (Irvine, CA, USA) and Siemens Healthcare (Erlangen, Germany) have signed an agreement to co-develop and market a next-generation software platform that will enable minimally invasive catheter-based procedures to be performed under the guidance of real-time magnetic resonance imaging (MRI).

Nearly all catheter-based interventions are currently done using fluoroscopy, an X-ray-based imaging technique. The software platform, to be used in combination with companion MRI-guided catheters, will enable procedures to be performed under MRI guidance rather than fluoroscopic guidance. This move to MRI-guided procedures is significant because MRI provides excellent visualization of soft tissue, MRI provides continuous three-dimensional (3D) visualization, and MRI scanning eliminates all radiation exposure for the patient and physician.

The new software platform will serve as the software component of MRI Interventions’ ClearTrace system. The full ClearTrace system, which is currently under development, is an integrated platform of software, reusable hardware, and disposable catheters designed to enable real-time, MRI-guided catheter interventions. MRI Interventions’ software will be a commercial successor to an innovative research software platform created by Siemens. Under a 2009 agreement between the companies, MRI Interventions and Siemens worked together closely on the development of the research platform, specifically for use in MRI-guided cardiac ablation procedures with MRI Interventions’ catheters.

MRI Interventions, under this new agreement, with cooperation and assistance from Siemens, will develop a commercial version of the research platform, for cardiac applications. Once the development work is completed, MRI Interventions will sell the software as its own product.

“We are pleased to continue our strong working relationship with MRI Interventions, a company that is helping to lead the industry into the emerging field of real-time MRI-guided procedures,” said Robert Krieg, VP of MR product innovation and definition at Siemens Healthcare. “We see tremendous potential to improve patient care by further expanding the therapeutic uses of MRI.”

MRI Interventions is an innovator in the field of real-time, MRI-guided therapeutic interventions. The company’s first product, the ClearPoint neurointervention system, is used commercially in the United States and Europe to enable MRI-guided, minimally invasive brain surgery. Similar to ClearTrace, the ClearPoint system is an integrated platform of software, reusable hardware, and disposable devices. The end result for the neurosurgeon is real-time, 3D visualization of the target neuroanatomy and surgical instruments with no radiation exposure for the patient or physician. MRI Interventions is developing these capabilities for catheter-based procedures outside of the brain with its ClearTrace system, with an initial focus on cardiac ablation procedures to treat arrhythmias.

“Effective evaluation and catheter-based treatment of patients suffering from complex cardiac arrhythmias have been impeded by poor visualization of patients’ cardiac tissue. Leading electrophysiology centers around the world are increasingly using MRI as the visualization platform to more accurately evaluate and stage their arrhythmia patients,” said Dr. Nassir Marrouche, associate professor of medicine and director of the electrophysiology lab at the University of Utah (Salt Lake City, USA) , and the executive director of the Comprehensive Arrhythmia Research & Management Center (CARMA). “As this trend gathers momentum, the next step is to move the cardiac ablation procedure into the MRI suite, with a system like ClearTrace. The CARMA team at the University of Utah has performed a large number of successful experimental studies using the ClearTrace system. Our experience with the system has been very good, and we are pleased this technology is moving forward to commercialization.”

“Interventional radiologists who have done research utilizing MRI guidance for catheter-based procedures are well aware of the many enticing benefits of moving from the fluoroscopic cath lab to the MRI suite,” said Dr. Aravind Arepally, section chief, vascular and interventional radiology, Piedmont Hospital (Atlanta, GA, USA). “It is exciting to hear that this capability is heading to a commercially-available product. This may not only provide an opportunity to improve certain current catheter-based fluoroscopic procedures but also may enable new procedures that are not currently feasible.”

“Siemens is the global market leader in MRI scanners. We have enjoyed an excellent working relationship with Siemens over the last few years and we are delighted to be taking this next step with them,” said Kimble Jenkins, CEO of MRI Interventions. “Extending the power of real-time MRI-guidance into catheter-based procedures represents another major opportunity in medicine. We believe that our ClearPoint system is transforming the way minimally invasive procedures are performed in the brain, and we hope to replicate this transformation for procedures in the body with our ClearTrace platform.”

The ClearTrace system is currently restricted for investigational use only and is not yet available for sale.

Related Links:
MRI Interventions
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58 (518.0835723877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1312.9711151123): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

60 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

61 (149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

62 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

63 (157.83309936523): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (678.06243896484): SELECT fid FROM jos_deeppockets WHERE id=294750995 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750995 AND published='1' LIMIT 1

65 (448.94218444824): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

66 (70.810317993164): select jos_twitters.link from jos_twitters where cat=10

67 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10

68 (39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10

69 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

70 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE id=294750995 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750995 AND published='1' LIMIT 1

71 (43.153762817383): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

72 (363.82675170898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (316.14303588867): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (84.161758422852): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (87.976455688477): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

107 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

108 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (198.1258392334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

111 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

112 (368.11828613281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (360.96572875977): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750995 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750992 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (350.9521484375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750992 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (609.8747253418): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (349.99847412109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

119 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

120 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

121 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

122 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

123 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

124 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

125 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

126 (437.97492980957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750995 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750995 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 557294.13032532): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (75.101852416992): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (293.01643371582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

131 (207.18574523926): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

132 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

133 (189.06593322754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

134 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

135 (427.9613494873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (427.0076751709): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (211.00044250488): SELECT name FROM jos_deeppockets WHERE id=216

138 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=216

139 (449.89585876465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (466.10832214355): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

142 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

143 (283.95652770996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

144 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

146 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

147 (!!!!! 1108.8848114014): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

148 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

149 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

150 (37.193298339844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750995 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750995 AND type='deeppockets_item' AND published='1' LIMIT 1

151 (431.06079101562): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

152 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

153 (32.901763916016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

154 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

155 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750995 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750995 AND published='1' LIMIT 1

156 (112.05673217773): select jos_twitters.link from jos_twitters where cat=10

157 (28.133392333984): select jos_facebook.link from jos_facebook where cat=10

158 (25.98762512207): select jos_google_plus.link from jos_google_plus where cat=10

159 (25.033950805664): select jos_linkedin.link from jos_linkedin where cat=10

160 (254.86946105957): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

161 (!!!!! 1409.7690582275): insert into jos_banners_delta values (14615,'2025-06-18 08:49:22','216.73.216.120','view'),(14202,'2025-06-18 08:49:22','216.73.216.120','view'),(14203,'2025-06-18 08:49:22','216.73.216.120','view')

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