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Atrophy in Thalamus Can Predict Multiple Sclerosis

By MedImaging International staff writers
Posted on 28 May 2013

Image: Composite 3D view of the thalamus of healthy controls (outlined in red) and MS patients (magenta). The whole thalamus is generally smaller in MS due to atrophy, and is also shifted (as seen in blue) slightly beyond the position of the normal thalamus due to atrophy of other parts of the brain (Photo courtesy of the University of Buffalo).

Magnetic resonance imaging (MRI) measurements of atrophy in a vital area of the brain are an accurate predictor of multiple sclerosis (MS), according to new findings. These measurements offer an improvement over current methods for evaluating patients at risk for MS.

MS develops as the body’s immune system attacks and damages myelin, the protective layer of fatty tissue that surrounds nerve cells within the brain and spinal cord. Symptoms include visual disturbances, muscle weakness, and trouble with coordination and balance. People with severe cases can lose the ability to speak or walk. About 85% of people with MS undergo a first, short-term neurologic episode known as clinically isolated syndrome (CIS). A definitive MS diagnosis is based on a combination of factors, including neurologic exams, medical history, development of a second clinical event, and detection of new and broadening lesions with contrast-enhanced or T2-weighted MRI.

The study’s findings were published online April 23, 2013, in the journal Radiology. “For some time we’ve been trying to understand MRI biomarkers that predict MS development from the first onset of the disease,” said Robert Zivadinov, MD, PhD, FAAN, from the Buffalo Neuroimaging Analysis Center of the University at Buffalo (NY, USA). “In the last couple of years, research has become much more focused on the thalamus.”

Recent studies found atrophy of the thalamus in all different MS disease types and detected thalamic volume loss in pediatric MS patients. “Thalamic atrophy may become a hallmark of how we look at the disease and how we develop drugs to treat it,” Dr. Zivadinov said.

Dr. Zivadinov and colleagues, for the study, examined the association between the development of thalamic atrophy and conversion to clinically confirmed MS. “One of the most important reasons for the study was to understand which regions of the brain are most predictive of a second clinical attack,” he said. “No one has really looked at this over the long term in a clinical trial.”

The researchers used contrast-enhanced MRI for initial assessment of 216 CIS patients. They performed follow-up scans at six months, one year, and two years. Over two years, 92 of 216 patients, or 42.6%, converted to clinically definite MS. Decreases in thalamic volume and increase in lateral ventricle volumes were the only MRI measures independently linked with the development of clinically definite MS. “First, these results show that atrophy of the thalamus is associated with MS,” Dr. Zivadinov said. “Second, they show that thalamic atrophy is a better predictor of clinically definite MS than accumulation of T2-weighted and contrast-enhanced lesions.”

The findings suggest that measurement of thalamic atrophy and increase in ventricular size may help identify patients at high risk for conversion to clinically definite MS in future clinical trials involving CIS patients. “Thalamic atrophy is an ideal MRI biomarker because it’s detectable at very early stage,” Dr. Zivadinov said. “It has very good predictive value, and you will see it used more and more in the future.”

The researchers continue to monitor the study group, with plans to publish findings from the four-year follow-up in 2015. They are also trying to determine more about the physiology of the thalamic involvement in MS. “The next step is to look at where the lesions develop over two years with respect to the location of the atrophy,” Dr. Zivadinov said. “Thalamic atrophy cannot be explained entirely by accumulation of lesions; there must be an independent component that leads to loss of thalamus.”

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62 (790.83442687988): SELECT fid FROM jos_deeppockets WHERE id=294746496 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746496 AND published='1' LIMIT 1

63 (476.83715820312): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

64 (69.856643676758): select jos_twitters.link from jos_twitters where cat=10

65 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

66 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

67 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

68 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE id=294746496 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746496 AND published='1' LIMIT 1

69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

70 (319.00405883789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (236.98806762695): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (60.796737670898): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (39.100646972656): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.200088500977): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

105 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

106 (54.836273193359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

109 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

110 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (505.92422485352): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (529.05082702637): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (325.91819763184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

115 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

116 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

118 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

119 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

120 (319.00405883789): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 19829.034805298): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

123 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

124 (370.02563476562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746496 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746496 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 441651.10588074): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (82.015991210938): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (621.08039855957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (428.91502380371): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (349.99847412109): SELECT name FROM jos_deeppockets WHERE id=216

136 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=216

137 (591.99333190918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (396.0132598877): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

140 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

141 (!!!!! 10599.851608276): TRUNCATE TABLE jos_trademed_module

142 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746496 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (663.99574279785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

147 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

148 (!!!!! 1231.1935424805): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

150 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

151 (52.213668823242): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746496 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746496 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (605.10635375977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

153 (48.87580871582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=216 or channel_id is null)

154 (51.975250244141): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

156 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746496 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746496 AND published='1' LIMIT 1

157 (44.107437133789): select jos_twitters.link from jos_twitters where cat=10

158 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

159 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

160 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

161 (307.79838562012): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1662.9695892334): insert into jos_banners_delta values (14615,'2025-06-18 14:48:32','216.73.216.120','view'),(14202,'2025-06-18 14:48:32','216.73.216.120','view'),(14203,'2025-06-18 14:48:32','216.73.216.120','view')

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