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The Biomarkers Consortium Announces Availability of Alzheimer's Disease Plasma Proteomics Data

By MedImaging International staff writers
Posted on 30 Dec 2010

A new project represents the work of a consortium venture that involves the use of targeted multiplex proteomic strategies to identify plasma-based biomarkers in Alzheimer's disease.

The Foundation for the US National Institutes of Health's (NIH) Biomarkers Consortium (Bethesda, MD, USA) announced that the results of a proteomics study performed utilizing plasma samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI; Los Angeles, CA, USA) are ready to be shared with scientists worldwide for further analysis.

This project is intended to be the first part of a multiphased effort seeking to utilize samples collected by ADNI to qualify multiplex panels in both plasma and cerebrospinal fluid (CSF) to diagnose patients with Alzheimer's disease (AD) and monitor disease progression. This information is available to the scientific community for download and further analysis via the ADNI website; more specific information about this data is available online (please see related links below).

"We are pleased to announce the release of this data, which represents a critical step towards the completion of this project,” remarked Scott E. Campbell, PhD, executive director and CEO of the Foundation for NIH.

This Biomarkers Consortium project utilized plasma samples collected by ADNI, a US$60 million project launched in 2004 which concludes by the end of 2010, which is a public-private partnership supported primarily by the NIH with pharmaceutical, imaging and clinical trial management companies; not-for-profit organizations; and donations from individuals providing support through the Foundation for the National Institutes of Health (FNIH).

One of the largest scale neuroimaging projects ever undertaken, ADNI involves longitudinal magnetic resonance imaging (MRI) and positron emission tomography (PET) brain imaging and blood, urine, and spinal fluid biomarker studies of more than 800 individuals, half of whom have mild cognitive impairment, a condition placing them at high risk for developing AD or another dementia. A renewal of the ADNI effort was announced in October 2010 by the Foundation for NIH and National Institute on Aging, which will continue ADNI for an additional five years through late 2015.

A Biomarkers Consortium-convened project team comprised of representatives from academia, industry, and government developed and executed this project and developed a statistical analysis plan, which is now being executed with the public release of these data. Holly Soares, PhD, director of clinical neuroscience biomarkers at Bristol-Myers Squibb (New York, NY, USA), who led the Biomarkers Consortium Project Team, said, "It was gratifying to work collaboratively with industry, academic, and government colleagues to generate a body of data that will tell us more about the biochemical makeup of Alzheimer's disease. Hopefully, the data may someday lead to a blood-based screening test for early diagnosis and preventative treatment of this devastating disease.”

John Q. Trojanowski, MD, PhD, who, with Dr. Leslie M. Shaw co-directs the ADNI Biomarker Core at the University of Pennsylvania (Philadelphia, PA, USA), said "This is another example of the efforts of ADNI and all ADNI stakeholders to make potentially valuable chemical biomarker data sets as broadly available to all scientists interested in Alzheimer biomarkers to accelerate the pace of biomarker discovery and validation for Alzheimer patients since this will have an important impact on the discovery and testing of disease modifying therapies for Alzheimer's disease. Dr. Trojanowski is the director of the Penn Institute on Aging and the NIA-funded Alzheimer's Disease Core Center at the University of Pennsylvania.

Established by the United States Congress to support the mission of the NIH--improving health through scientific discovery in the search for cures--the Foundation for NIH is a leader in identifying and addressing complex scientific and health issues.

The Biomarkers Consortium is a public-private biomedical research partnership managed by the Foundation for the National Institutes of Health (FNIH) that endeavors to develop, validate, and/or qualify biologic markers (biomarkers) to speed the development of medicines and therapies for detection, prevention, diagnosis, and treatment of disease and improve patient care.

Related Links:
The Foundation for the US National Institutes of Health's Biomarkers Consortium
Alzheimer's Disease Neuroimaging Initiative
ADNI Data

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58 (403.88107299805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1614.0937805176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

60 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

61 (91.791152954102): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

62 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

63 (69.141387939453): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (488.0428314209): SELECT fid FROM jos_deeppockets WHERE id=294732731 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294732731 AND published='1' LIMIT 1

65 (362.87307739258): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

66 (49.114227294922): select jos_twitters.link from jos_twitters where cat=10

67 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

68 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

69 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

70 (33.140182495117): SELECT fid FROM jos_deeppockets WHERE id=294732731 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294732731 AND published='1' LIMIT 1

71 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

72 (311.13624572754): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (234.84230041504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

107 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

108 (63.180923461914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (44.107437133789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

111 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

112 (370.02563476562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (386.95335388184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732729 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (369.07196044922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294732729 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (547.88589477539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (315.18936157227): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

120 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

121 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

122 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

123 (!!!!! 2820.0149536133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

124 (339.98489379883): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 29933.929443359): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

127 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

128 (398.87428283691): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732731 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732731 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 764825.10566711): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (!!!!! 998375.89263916): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (79.154968261719): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (464.20097351074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (420.80879211426): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (199.0795135498): SELECT name FROM jos_deeppockets WHERE id=216

140 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=216

141 (536.91864013672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (541.92543029785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (!!!!! 1145.1244354248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

144 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

145 (!!!!! 29725.790023804): TRUNCATE TABLE jos_trademed_module

146 (!!!!! 2108.097076416): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (789.88075256348): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294732731 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1015.9015655518): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (925.06408691406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (!!!!! 2414.9417877197): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

151 (317.09671020508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

152 (!!!!! 1240.9687042236): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (550.98533630371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

154 (431.77604675293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

155 (!!!!! 4245.0428009033): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294732731 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294732731 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (!!!!! 1156.0916900635): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

157 (152.8263092041): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (257.96890258789): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (937.93869018555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

160 (167.8466796875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294732731 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294732731 AND published='1' LIMIT 1

161 (319.9577331543): select jos_twitters.link from jos_twitters where cat=10

162 (110.86463928223): select jos_facebook.link from jos_facebook where cat=10

163 (91.075897216797): select jos_google_plus.link from jos_google_plus where cat=10

164 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

165 (292.06275939941): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1494.1692352295): insert into jos_banners_delta values (14615,'2025-06-20 00:03:29','216.73.216.120','view'),(14202,'2025-06-20 00:03:29','216.73.216.120','view'),(14203,'2025-06-20 00:03:29','216.73.216.120','view')

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