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Diseñan herramientas para diagnóstico más temprano de cáncer de mama

By MedImaging International staff writers
Posted on 07 Sep 2010

Técnicas avanzadas para investigar sospecha del cáncer de mama están complementando la mamografía tradicional. Un equipo de investigadores europeos y norteamericanos está desarrollando formas de combinar todos estos datos para ayudarles a los médicos a hacer diagnósticos más tempranos y más exactos.

Puesto que las causas del cáncer de mama no se entienden bien, la prioridad es detectarlo tempranamente para que se pueda dar un tratamiento efectivo. Entre más temprano se detecte el cáncer, mayor probabilidad de éxito tiene el tratamiento. Muchos países emplean ahora la mamografía con rayos X para estudiar a las mujeres de más de 40 o 50 años, pero se siguen presentando casos sin detectar debido a la dificultad de hacer un diagnóstico exacto. Aún con los mamogramas, algunos cánceres pasarán desapercibidos y habrá muchos casos de falsos positivos que requieren investigaciones adicionales. La validación se hace típicamente con ultrasonido y biopsias, pero muchas biopsias mostrarán que la masa sospechosa no es cancerosa.

"Con los mamogramas no siempre se puede ver si hay algo serio o si es algo que no es cáncer”, dijo la Dra. Sonja Guttenbrunner del Instituto Europeo de Imagenología Biomédica (Viena, Austria). "Algunas veces es muy difícil detectar el cáncer de mama y con frecuencia, se toman biopsias innecesarias”.

Aún si se confirma cáncer, algunos tipos nunca tendrán riesgo para la salud, pero no se pueden diferenciar fácilmente de tumores que tienen la posibilidad de diseminarse. El resultado es que muchas mujeres se someten a cirugía, radioterapia y quimioterapia que no necesariamente lo requieren, si hubiese sido posible un diagnóstico más preciso.

Otras herramientas diagnósticas, como el ultrasonido, se usan normalmente como un seguimiento a la mamografía. Técnicas más novedosas incluyen la tomosíntesis de rayos-X, la resonancia magnética, la mamografía de emisión de positrones (MEP) y el ultrasonido automatizado en tres dimensiones (3D). Todas estas técnicas revelan datos diversos sobre cualquier masa sospechosa y juntos le pueden ayudar al médico a tomar una decisión más informada y exacta.

¿Pero cuál es la mejor forma de usar todas estas fuentes de información? Aquí es donde ingresa el Proyecto HAMAM, financiado por la Unión Europea (UE) (Viena, Austria). HAMAM (Diagnóstico Altamente Exacto para el Cáncer de mama mediante la Integración del Conocimiento Biológico, Modalidades Novedosas de Imagenología y Modelaje) está desarrollando una herramienta que será más exacta para el diagnóstico del cáncer de mama y podrá integrar todas estas modalidades diferentes en una sola estación de trabajo clínica, sugiere la Dra. Guttenbrunner, quien está coordinando el proyecto.

Los médicos podrán comparar diferentes imágenes lado a lado, mientras que ven la historia de la paciente e información adicional. HAMAM también busca ayudarles a los médicos con un elemento de diagnóstico por computadora. La estación de trabajo estará conectada a una base de datos extensa de imágenes y otros datos clínicos. Podrá recomendar investigaciones adicionales para ayudar al médico a diagnosticar.

El proyecto tiene una estación de trabajo prototipo que se está evaluando en preparación para una demostración pública. Una base de datos prototipo está disponible y los socios clínicos han suministrado información anónima de los pacientes.

Los socios clínicos en el proyecto incluyen hospitales de Berlín (Alemania), Dundee (Reino Unido), Nijmegen (Holanda), y un socio en los Estados Unidos. El Hospital Comunitario de Boca Ratón (FL, EUA) fue elegido por su experiencia en el uso de imágenes multimodales para el diagnóstico de cáncer de mama. Están suministrando gran parte de la información usada para construir la base de datos.

"El cáncer de mama es un problema mundial, tanto epidemiológica como económicamente, pero de manejo distinto en Europa que en los Estados Unidos, agregó la Dra. Guttenbrunner. "Por lo tanto, la investigación conjunta es una buena manera de combinar las diferentes perspectivas”. Ellos están apoyados por socios tecnológicos en Londres [Reino Unido], Bremen [Alemania], Nijmegen, y Zúrich [Suiza]. "Al final del proyecto, queremos tener una estación de trabajo que pueda ser introducida en el mercado”, dijo. "Tenemos un socio industrial, Mevis Medical Solutions [Bremen], que continuará el desarrollo de la estación de trabajo para realmente llevarla al mercado para los médicos”.

HAMAM se basa en dos proyectos anteriores financiados por la UE, SCREEN y SCREEN-TRIAL, que desarrollaron métodos para leer mamografías tomadas de una pantalla de visualización digital en vez de las películas tradicionales de rayos X.

Enlaces relacionados:

European Institute for Biomedical Imaging
HAMAM Project

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50 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

51 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

52 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

53 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

54 (463.00888061523): SELECT name FROM jos_deeppockets WHERE id=294731035 LIMIT 1

55 (330.92498779297): SELECT name FROM jos_deeppockets_archive WHERE id=294731035 LIMIT 1

56 (143.05114746094): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (630.85556030273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1535.177230835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

60 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

61 (159.02519226074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

62 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

63 (153.0647277832): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (623.94142150879): SELECT fid FROM jos_deeppockets WHERE id=294731035 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731035 AND published='1' LIMIT 1

65 (466.82357788086): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

66 (69.141387939453): select jos_twitters.link from jos_twitters where cat=10

67 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

68 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

69 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

70 (50.783157348633): SELECT fid FROM jos_deeppockets WHERE id=294731035 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731035 AND published='1' LIMIT 1

71 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=216 ORDER BY `ordering`

72 (376.93977355957): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (308.99047851562): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (68.902969360352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (41.007995605469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

107 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

108 (88.930130004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (68.187713623047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

111 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

112 (500.91743469238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (498.05641174316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731031 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (567.19779968262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731031 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 5889.892578125): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (!!!!! 3229.1412353516): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

119 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

120 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

121 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

122 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

123 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

124 (506.16264343262): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 56675.19569397): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (347.85270690918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

127 (201.94053649902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

128 (!!!!! 1393.0797576904): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731035 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731035 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 660424.94773865): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (102.99682617188): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (72.956085205078): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (616.07360839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (586.98654174805): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (253.20053100586): SELECT name FROM jos_deeppockets WHERE id=216

140 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=216

141 (655.8895111084): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (474.92980957031): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))216((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

144 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

145 (!!!!! 11261.940002441): TRUNCATE TABLE jos_trademed_module

146 (144.00482177734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (88.214874267578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731035 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1000.1659393311): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

151 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

152 (!!!!! 1626.9683837891): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

154 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

155 (68.902969360352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731035 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731035 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

157 (46.014785766602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

158 (63.180923461914): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (181.91337585449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

160 (81.777572631836): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731035 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731035 AND published='1' LIMIT 1

161 (55.074691772461): select jos_twitters.link from jos_twitters where cat=10

162 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

163 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

164 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

165 (388.86070251465): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1687.0498657227): insert into jos_banners_delta values (14615,'2025-06-20 06:54:22','216.73.216.120','view'),(14202,'2025-06-20 06:54:22','216.73.216.120','view'),(14203,'2025-06-20 06:54:22','216.73.216.120','view')

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