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CT Scans Beats Genetics at Predicting Heart Attack Risk

By MedImaging International staff writers
Posted on 24 May 2023

Image: CT scan is best at predicting heart disease risk in middle age (Photo courtesy of Freepik)

Traditionally, doctors have relied on standard risk-factor levels, such as blood pressure and cholesterol, to assess an individual's likelihood of developing coronary heart disease or heart artery blockages. However, these conventional methods can fail to identify some people at risk of heart attacks or other heart-related conditions. Given the hereditary nature of heart disease, scientists have been hopeful that a person's genetics could provide insight into who is most at risk. The concept of polygenic risk scores - a compilation of over 6 million common genetic variants associated with heart disease - was seen as a potential leap forward for personalized medicine. A recent study, however, has found that CT scans are more accurate than genetics in predicting a middle-aged person’s risk for heart disease, such as a heart attack.

In the study, researchers at Northwestern University (Evanston, IL, USA) directly compared the efficacy of genetics and CT scans for coronary artery calcium and demonstrated that the CT scan is superior to genetics at predicting heart disease risk in middle-aged individuals. The study incorporated data from 3,208 adults across two cohorts - one in the U.S. and the other in Rotterdam, Netherlands. This data included risk factors for heart disease (such as smoking status, cholesterol levels, and blood pressure), genetic information, and CT scan data to estimate the risk of developing heart disease over a follow-up period of up to 17 years.

The researchers examined how using either CT scans or polygenic risk scores altered the predicted risk of individuals based on conventional risk factors such as blood pressure and cholesterol. They investigated whether adding either of these markers (CT or genetics) shifted individuals into a different risk category. A low risk individual is defined as someone with less than a 7.5% risk of developing heart disease in the next decade. Those with a risk above 7.5% are typically recommended statins. The study found that genetic data did not affect a person’s risk category based on their conventional risk factors. However, when CT scan data was considered, half the study participants were reclassified into the high-risk group.

“Finding the best way to identify who is at risk for developing heart disease can help determine what needs to be done to lower their risk,” said lead study author Dr. Sadiya Khan, an assistant professor of medicine and preventive medicine at Northwestern University Feinberg School of Medicine and a Northwestern Medicine cardiologist. “This finding can help doctors and patients in managing risk for heart disease, which is the leading cause of death in the U.S.”

“These findings support recommendations to consider CT screening to calculate risk for heart disease in middle-aged patients when their degree of risk is uncertain or in the intermediate range,” Khan said. “The data from the CT scan can help identify individuals who may benefit from medications, such as statins, to reduce their risk of heart disease.”

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68 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE id=294797315 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294797315 AND published='1' LIMIT 1

69 (36.001205444336): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (468.96934509277): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (290.87066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (511.88468933105): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (656.1279296875): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (!!!!! 1754.9991607666): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (160.93254089355): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (166.17774963379): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (427.0076751709): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (95.129013061523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (86.069107055664): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (75.101852416992): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (415.08674621582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (245.80955505371): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 1406.9080352783): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (128.03077697754): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (349.04479980469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1979.1126251221): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

105 (367.87986755371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

106 (288.96331787109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (382.1849822998): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1291.036605835): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

109 (185.96649169922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

110 (!!!!! 1868.0095672607): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (479.93659973145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (673.05564880371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (403.88107299805): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

115 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

116 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

117 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

118 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

119 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

120 (179.05235290527): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 42937.040328979): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (!!!!! 4944.0860748291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

123 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

124 (364.06517028809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797315 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797315 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 579859.01832581): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (144.95849609375): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (406.98051452637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (321.86508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (291.82434082031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (357.15103149414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (349.04479980469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (330.92498779297): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (158.07151794434): SELECT name FROM jos_deeppockets WHERE id=215

136 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=215

137 (613.92784118652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (543.11752319336): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

140 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

141 (!!!!! 13710.975646973): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 3239.8700714111): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (!!!!! 1048.0880737305): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797315 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 1169.9199676514): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (170.94612121582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

147 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

148 (!!!!! 2038.0020141602): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

150 (423.19297790527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

151 (679.96978759766): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797315 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797315 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (34.809112548828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (164.03198242188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

156 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797315 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797315 AND published='1' LIMIT 1

157 (264.88304138184): select jos_twitters.link from jos_twitters where cat=10

158 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

159 (36.954879760742): select jos_google_plus.link from jos_google_plus where cat=10

160 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

161 (337.83912658691): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 8342.981338501): insert into jos_banners_delta values (14615,'2025-04-30 12:30:42','3.128.24.183','view'),(14202,'2025-04-30 12:30:42','3.128.24.183','view'),(14203,'2025-04-30 12:30:42','3.128.24.183','view')

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