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Novel Photon-Counting CT Improves Myeloma Bone Disease Detection

By MedImaging International staff writers
Posted on 07 Sep 2022

Image: New CT technology paired with AI-based noise reduction improves myeloma bone disease detection (Photo courtesy of Pexels)

Multiple myeloma is a disease that forms in a type of white blood cell found in the bone marrow called a plasma cell. Bone disease characterized by areas of bone destruction known as lytic lesions is found in approximately 80% of multiple myeloma patients. Low-dose, whole-body CT is recommended to evaluate associated bone disease. Now, a study has found that new CT technology paired with artificial intelligence (AI)-based noise reduction offers superior detection of bone disease associated with multiple myeloma at lower radiation doses than conventional CT. The new technology, known as photon-counting detector CT, debuted in the clinic in 2021 after decades of development, although much less is known about the technology to evaluate associated bone disease.

The potential for improved image quality in whole-body low-dose scans inspired researchers at the Mayo Clinic (Rochester, MN, USA) to study the technology in people with multiple myeloma. By directly converting individual X-ray photons into an electric signal, photon-counting detector CT can decrease the detector pixel size and improve the image’s spatial resolution. For their study, the researchers compared photon-counting detector CT with conventional low-dose, whole-body CT in 27 multiple myeloma patients, median age 68 years. The patients underwent whole-body scans with both types of CT and two radiologists compared the images. The researchers also applied a deep learning AI technique developed at Mayo Clinic’s CT Clinical Innovation Center to reduce the noise in the very sharp photon-counting images.

CT noise refers to an unwanted change in pixel values in the image, often loosely defined as the grainy appearance on cross-sectional imaging. The photon-counting detector CT with deep learning noise reduction demonstrated improvement in visualization and detected more lesions relative to conventional CT. The researchers now hope to conduct follow-up studies on patients with multiple myeloma precursor states to see if photon-counting detector CT finds bone lesions that would upstage these patients to active multiple myeloma. They also want to look at photon-counting detector CT in other instances in which low-dose protocols are beneficial, for instance, in pediatric or pregnant patients or screening applications.

“We were excited to see that not only were we able to detect these features of multiple myeloma disease activity more clearly on the photon-counting scanner,” said study lead author Francis Baffour, M.D., diagnostic radiologist at the Mayo Clinic, “with deep learning denoising techniques that allowed us to generate thinner image slices, we were able to detect more lesions than on the standard CT.”

“Our excitement as scientists and radiologists in these results stems from our realization that this scanner could make a difference in the staging of disease, potentially impact therapy choice, and ultimately, patient outcomes,” added Baffour.

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68 (385.04600524902): SELECT fid FROM jos_deeppockets WHERE id=294794498 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294794498 AND published='1' LIMIT 1

69 (308.99047851562): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (299.93057250977): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (357.86628723145): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (213.8614654541): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (205.99365234375): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (!!!!! 1271.9631195068): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (205.99365234375): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (!!!!! 3610.1341247559): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (431.06079101562): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (677.10876464844): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (242.94853210449): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (519.0372467041): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (264.88304138184): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (238.89541625977): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (939.13078308105): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (725.98457336426): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (257.96890258789): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 3790.1401519775): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (115.87142944336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 3024.8165130615): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (259.1609954834): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1250.9822845459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

105 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

106 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (44.107437133789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2181.0531616211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

109 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

110 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (417.94776916504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (536.91864013672): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (347.13745117188): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

115 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

116 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

117 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

118 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

119 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

120 (344.99168395996): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 66174.030303955): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (192.88063049316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

123 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

124 (!!!!! 1164.9131774902): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794498 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794498 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1455008.9836121): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (75.101852416992): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (27.179718017578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (370.02563476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (323.05717468262): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=215

136 (27.179718017578): SELECT name FROM jos_deeppockets WHERE id=215

137 (435.11390686035): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (360.01205444336): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

140 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

141 (!!!!! 10491.847991943): TRUNCATE TABLE jos_trademed_module

142 (128.98445129395): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794498 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (391.00646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

147 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

148 (!!!!! 1083.8508605957): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

150 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

151 (37.908554077148): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794498 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794498 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (28.848648071289): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (823.02093505859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

156 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794498 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794498 AND published='1' LIMIT 1

157 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

158 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

159 (26.941299438477): select jos_google_plus.link from jos_google_plus where cat=10

160 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

161 (247.00164794922): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1108.8848114014): insert into jos_banners_delta values (14615,'2025-05-01 02:02:31','3.14.133.138','view'),(14202,'2025-05-01 02:02:31','3.14.133.138','view'),(14203,'2025-05-01 02:02:31','3.14.133.138','view')

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