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New Imaging Approach Combines MRI, CT and Optical Microscopy Images to Create Stunning 3D Visualizations of Blood Vessels

By MedImaging International staff writers
Posted on 01 Mar 2022
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Image: VascuViz imaging pipeline (Photo courtesy of Johns Hopkins Medicine)
Image: VascuViz imaging pipeline (Photo courtesy of Johns Hopkins Medicine)

Scientists have developed a new method for making blood vessels visible, from the smallest cells to the largest organs.

Researchers at Johns Hopkins Medicine (Baltimore, MD, USA) have developed and tested a new imaging approach they say will accelerate imaging-based research in the lab by allowing investigators to capture images of blood vessels at different spatial scales. Tested in mouse tissues, the method, dubbed “VascuViz,” includes a quick-setting polymer mixture to fill blood vessels and make them visible in multiple imaging techniques. The approach enables researchers to visualize the structure of a tissue’s vasculature, which in conjunction with detailed mathematical models or complementary images of other tissue elements can clarify the complex role of blood flow in health and disease. The combined images of the blood vessels should not only enhance the study of the biology of diseases that involve abnormalities in blood flow, such as cancer and stroke, but also advance our understanding of the structures and functions of tissues throughout the body.

Researchers use many different imaging methods, such as MRI, CT and microscopy to study the role of blood vessels in the lab. These images are useful for understanding the dynamics of how tissues develop disease or respond to treatment. However, integrating the data available in these images has remained a challenge because agents used to make a blood vessel visible to one imaging method can make it invisible on other tools. This limits the amount of data researchers can gather from a single sample.

VascuViz overcomes this problem by making the structure of the largest arteries to the smallest microvasculature visible to a variety of imaging tools, which allows researchers to develop a multilayered understanding of blood vessels and related tissue components with less time and effort. The development of VascuViz is particularly useful in creating computerized visualizations of how complex biological systems such as the circulatory system work, and is a hallmark of the growing field of “image-based” vascular systems biology.

To create VascuViz, the researchers tested several combinations of existing imaging agents and their suitability for different imaging methods. After multiple iterations, they found that a CT contrast agent named BriteVu and a fluorescently labeled MRI contrast agent called Galbumin-Rhodamine could be combined to create a compound that makes the macro- and microvasculature simultaneously visible when imaging with MRI, CT and optical imaging techniques without interference. With the compound working in test tubes, the researchers then tested it in a variety of mouse tissues, perfusing it through the vascular system of breast cancer models, leg muscles, the brain and kidney tissues. The resulting images of the tissues acquired with MRI, CT and optical microscopy were then combined to create stunning 3D visualizations of the vasculature and associated components comprising these disease model and organ systems. Due to VascuViz’s affordability and commercially available components, the research team hopes that it is globally adopted by scientists to help shed new light on different diseases involving the vasculature.

“Now, rather than using an approximation, we can more precisely estimate features like blood flow in actual blood vessels and combine it with complementary information, such as cell density,” said Akanksha Bhargava, Ph.D., postdoctoral fellow in the Pathak Lab within the Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine.

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90 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (96.797943115234): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (452.99530029297): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (!!!!! 2413.9881134033): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
105 (273.9429473877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
106 (494.95697021484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (699.04327392578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 6033.182144165): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
109 (!!!!! 6675.0049591064): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
110 (432.01446533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (!!!!! 1120.0904846191): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (895.97702026367): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (!!!!! 1442.9092407227): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
115 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
116 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
117 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
118 (262.02201843262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
119 (299.93057250977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
120 (!!!!! 2420.9022521973): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121 (!!!!! 56089.162826538): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
122 (358.81996154785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
123 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
124 (880.95664978027): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791777 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791777 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 1371851.9210815): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (236.98806762695): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (165.93933105469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
128 (63.180923461914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
129 (81.062316894531): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
130 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
131 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
132 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
133 (!!!!! 1039.981842041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
134 (714.77890014648): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
135 (978.94668579102): SELECT name FROM jos_deeppockets WHERE id=215
136 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=215
137 (475.16822814941): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
138 (355.00526428223): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
139 (676.15509033203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
140 (148.77319335938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
141 (!!!!! 25407.075881958): TRUNCATE TABLE jos_trademed_module
142 (!!!!! 3113.0313873291): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
143 (!!!!! 1281.9766998291): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791777 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
144 (!!!!! 1806.0207366943): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146 (390.76805114746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
147 (367.87986755371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
148 (!!!!! 1660.8238220215): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
149 (459.19418334961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
150 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
151 (222.92137145996): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791777 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791777 AND type='deeppockets_item' AND published='1' LIMIT 1
152 (229.1202545166): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)
153 (39.815902709961): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)
154 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155 (762.939453125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
156 (!!!!! 2002.9544830322): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791777 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791777 AND published='1' LIMIT 1
157 (356.91261291504): select jos_twitters.link from jos_twitters where cat=10
158 (383.85391235352): select jos_facebook.link from jos_facebook where cat=10
159 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10
160 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10
161 (!!!!! 1051.9027709961): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
162 (!!!!! 5847.9309082031): insert into jos_banners_delta values (14615,'2025-05-02 02:09:29','3.147.77.120','view'),(14202,'2025-05-02 02:09:29','3.147.77.120','view'),(14203,'2025-05-02 02:09:29','3.147.77.120','view')