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AI-Reconstructed Medical Images May Be Unreliable

By MedImaging International staff writers
Posted on 16 Jun 2020

Image: Images with small structural perturbations (text and symbols) reconstructed with AI (Photo courtesy of PNAS)

A new study suggest that the deep learning tools used to create high-quality images from short scan times produce multiple alterations and artefacts in the data that could affect diagnosis.

Researchers at the University of Oslo (Norway), the University of Cambridge (United Kingdom), and other institutions conducted a study to test six different artificial intelligence (AI) neural networks trained to create enhanced images from magnetic resonance imaging (MRI) or computerized tomography (CT) scans. The networks were fed data designed to replicate three possible issues: tiny perturbations; small structural changes; and changes in the sampling rate compared with the data on which the AI was trained on. To test the ability of the systems to detect small structural changes, the team added letters and symbols from playing cards to the images.

The results showed that only one of the networks was able to reconstruct these details, but the other five presented issues ranging from blurring to almost complete removal of the changes. Only one of the neural networks produced better images as the researchers increased the sampling rate of the scans. Another network stagnated, with no improvement in quality; and in three, the reconstructions dropped in quality as the number of samples increased. The sixth AI system did not allow the sampling rate to be changed. The study was published on May 11, 2020, in the Proceedings of the National Academy of Sciences (PNAS).

“You take a tiny little perturbation and the AI system says the image of the cat is suddenly a fire truck; researchers need to start testing the stability of these systems. What they will see on a large scale is that many of these AI systems are unstable,” said senior author Anders Hansen, PhD, of the University of Cambridge. “The big, big, problem is that there is no mathematical understanding of how these AI systems work. They become a black box, and if you don’t test these things properly you can have completely disastrous outcomes.”

Instabilities during scanning can appear as certain tiny, almost undetectable perturbations (for example due to patient movement, that appear in both the image and sampling domain, resulting in artefacts in the reconstruction; as small structural changes, for example, a tumor, that may not be captured in the reconstructed image; and differing sampling rates that do not coincide with the data on which the AI algorithm was trained.

Related Links:
University of Oslo
University of Cambridge

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70 (279.90341186523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (232.93495178223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (272.03559875488): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (120.16296386719): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (293.01643371582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (69.856643676758): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1429.7962188721): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

105 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

106 (88.930130004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

109 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

110 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (457.0484161377): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 7715.9404754639): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 8001.0890960693): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 7716.178894043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

115 (!!!!! 7988.9297485352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

116 (!!!!! 7802.9632568359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

117 (!!!!! 7966.0415649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

118 (!!!!! 7770.0614929199): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

119 (!!!!! 7177.8297424316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

120 (!!!!! 7879.9724578857): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 108035.08758545): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (!!!!! 7629.8713684082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

123 (!!!!! 7997.989654541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

124 (!!!!! 7835.865020752): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782965 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782965 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1277856.1115265): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (77.962875366211): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (26.941299438477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (445.12748718262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (344.99168395996): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (53.167343139648): SELECT name FROM jos_deeppockets WHERE id=215

136 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=215

137 (434.87548828125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (442.0280456543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

140 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

141 (!!!!! 7826.0898590088): TRUNCATE TABLE jos_trademed_module

142 (985.14556884766): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (576.97296142578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294782965 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (370.97930908203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (62.227249145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

147 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

148 (!!!!! 1100.0633239746): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

150 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

151 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294782965 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294782965 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (57.93571472168): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (41.007995605469): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

156 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294782965 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294782965 AND published='1' LIMIT 1

157 (177.86026000977): select jos_twitters.link from jos_twitters where cat=10

158 (95.844268798828): select jos_facebook.link from jos_facebook where cat=10

159 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

160 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

161 (316.85829162598): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1389.9803161621): insert into jos_banners_delta values (14615,'2025-06-18 21:31:10','216.73.216.120','view'),(14202,'2025-06-18 21:31:10','216.73.216.120','view'),(14203,'2025-06-18 21:31:10','216.73.216.120','view')

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