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Computational Electrodynamics Predict Risk of Cancer

By MedImaging International staff writers
Posted on 27 Aug 2019

Image: Nanoscale structure alterations of live cells observed using PWS optical microscopy (Photo courtesy of Vadim Backman/ NU).

A new study describes a technique to detect macromolecular alterations at the cellular level that can be used to predict and quantify cancer risk at extremely early stages.

Developed at Northwestern University (NU; Chicago, IL, USA) and Argonne National Laboratory (ANL; Lemont, IL, USA), the new method is based on high-throughput optical microscopy technique and the ANL supercomputing Mira system. Using the open-source Angora software simulation tool, the computational electrodynamics technique converts static partial wave spectroscopy (PWS, an analysis of intracellular activity based on single snapshots), into dynamic PWS, which conveys information about a cell's inner processes by observing that cell's evolution through time.

By employing dynamic PWS, the researchers were able to measure the intracellular nanoscale structure and macromolecular dynamics of living cells, sensitive to changes as small as 20 nanometers, and with millisecond temporal resolution. With Angora finite-difference time domain (FDTD) computations, the researchers explored higher-order chromatin structure and dynamics changes attributable to cellular fixation, stem-cell differentiation, and ultraviolet (UV) irradiation. They discovered a new phenomenon called cellular paroxysm, a synchronous, nearly instantaneous burst of intracellular motion that occurs early in the process of UV-induced cell death.

The researchers suggest the technique could be used to study the field effect, which posits that cancer detection can be accomplished by properly analyzing seemingly normal tissue located some distance from afflicted lesions, such as a buccal swab to identify lung cancer, or a Pap smear to detect ovarian and cervical cancer. PWS could determine the degree of randomness of nanometric fluctuations of density within the cell, which in turn could be correlated to the presence of a cancer deeper in the body whose "field" includes the cell under analysis. A study describing the PWS method was published in the April 2019 issue of Nature Communications.

“Rigorously solving Maxwell's equations on nanometer-size voxels ultimately allows Angora to create full-color pixels at the image plane. These pixels can then be analyzed for spectral content,” explained Professor Allen Taflove, PhD, of NU. “After optimizing Angora for Mira, we've been able to solve for more than one trillion vector electromagnetic field components, which we think is unique among such software. Furthermore, by distinguishing between 20-nanometer fluctuations and 50-nanometer fluctuations, Angora far exceeds the capabilities of conventional microscopes.”

“The combination of our experimental and Angora computational studies has given us confidence that dynamic PWS provides the means with which to obtain nanoscale-sensitive, millisecond-resolved information within living cells without the need for any staining,” concluded Professor Taflove. “The impressive spatial-temporal resolution capabilities of dynamic PWS open the door for high-fidelity, high-throughput, early-stage cancer screening, and possibly even novel cancer therapies.”

Spectroscopy, primarily in the electromagnetic spectrum, is a fundamental exploratory tool in the fields of physics, chemistry, biology and astronomy, allowing the composition, physical structure, and electronic structure of matter to be investigated at atomic, molecular scale, and macro scale, and even over astronomical distances.

Related Links:
Northwestern University
Argonne National Laboratory

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68 (52.928924560547): SELECT fid FROM jos_deeppockets WHERE id=294779124 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294779124 AND published='1' LIMIT 1

69 (46.968460083008): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=215 ORDER BY `ordering`

70 (355.95893859863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (295.87745666504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (70.095062255859): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (309.94415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (90.837478637695): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (121.11663818359): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (108.00361633301): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (85.830688476562): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (83.92333984375): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (877.85720825195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (73.909759521484): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (38.14697265625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 4534.9597930908): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (192.88063049316): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

105 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

106 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (292.06275939941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

109 (112.05673217773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

110 (246.04797363281): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (692.84439086914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (805.13954162598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (524.99771118164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (191.92695617676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

115 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

116 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

117 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

118 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

119 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

120 (207.90100097656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 85932.970046997): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (318.05038452148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

123 (197.8874206543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

124 (!!!!! 4087.9249572754): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779124 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779124 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1447413.9213562): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1392530.9181213): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (200.98686218262): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (109.91096496582): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (!!!!! 2372.0264434814): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (!!!!! 12621.879577637): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (!!!!! 1275.0625610352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (!!!!! 4102.9453277588): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (453.94897460938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (329.01763916016): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=215

136 (29.802322387695): SELECT name FROM jos_deeppockets WHERE id=215

137 (508.06999206543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (404.11949157715): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1019.9546813965): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

140 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

141 (!!!!! 14454.126358032): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 2986.9079589844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (747.9190826416): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294779124 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (469.92301940918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (99.18212890625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

147 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

148 (!!!!! 4414.0815734863): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (193.83430480957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

150 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

151 (532.15026855469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294779124 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294779124 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

156 (62.227249145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294779124 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294779124 AND published='1' LIMIT 1

157 (!!!!! 4115.8199310303): select jos_twitters.link from jos_twitters where cat=10

158 (92.983245849609): select jos_facebook.link from jos_facebook where cat=10

159 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

161 (329.97131347656): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1519.9184417725): insert into jos_banners_delta values (14615,'2025-06-19 13:01:58','216.73.216.120','view'),(14202,'2025-06-19 13:01:58','216.73.216.120','view'),(14203,'2025-06-19 13:01:58','216.73.216.120','view')

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