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Digital Pathology System Aids Primary Diagnosis

By MedImaging International staff writers
Posted on 11 Jun 2019

Image: The Aperio AT2 digital pathology scanner (Photo courtesy of Leica Biosystems).

A small footprint, high throughput digital pathology scanner allows slides to be available for remote viewing in less than a minute.

The Leica Biosystems (Vista, CA, USA) Aperio AT2 400-slide capacity brightfield scanner is designed to support a sustained high throughput rate of 50 slides per hour. The highly reliable autoloader, with a 400-slide capacity, can capture and prepare digitized slides from an entire carousel in less than eight hours, thanks to a smaller file size and faster scanning with skip blank stripes technology. Other features include Z-stacking with up to 25 layers and a light emitting diode (LED) light source with calibration controls that ensure consistent, high quality scanning.

An adjustable tissue finder allows the area of interest to be adjusted in order to optimize findings on difficult samples (such as fatty tissue), or to be programmed to not detect ink or stain residues. A pathologist's cockpit, clinical image management software that runs on the Microsoft Windows 10 operating system, and easy integration into laboratory information systems (LIS) provides an integrated digital pathology workflow solution.

“Leica Biosystems has always had a commitment to rapid and sustained innovation in this space. We bring to bear deep product expertise, as well as comprehensive IT implementation skills for seamless customer installs,” said Jerome Clavel, vice president and general manager of pathology imaging at Leica Biosystems. “The digital pathology market is growing very quickly; by leveraging our commercial presence in over 100 countries, we have now built an installed base of 2,000 systems. China and North America stand out with over 400 installs over the last 24 months alone.”

Digital pathology is an image-based information environment enabled by computer technology that allows for the management of information generated from a digital slide. It is enabled in part by virtual microscopy (the conversion of glass slides into digital slides) that can be viewed, managed, shared and analyzed on a computer monitor. With the advent of whole-slide imaging, digital pathology is currently regarded as one of the most promising avenues of diagnostic medicine.

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72 (51.021575927734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

105 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (45.061111450195): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

109 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

110 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (529.05082702637): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (642.06123352051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (329.97131347656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

115 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

116 (169.03877258301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

117 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

118 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

119 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

120 (364.06517028809): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 28294.801712036): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

123 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

124 (485.18180847168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294778272 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294778272 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 909772.15766907): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1692395.9255219): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (94.890594482422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (519.99092102051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (504.97055053711): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=215

136 (38.14697265625): SELECT name FROM jos_deeppockets WHERE id=215

137 (566.95938110352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (556.94580078125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1281.9766998291): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

140 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

141 (!!!!! 17657.041549683): TRUNCATE TABLE jos_trademed_module

142 (458.0020904541): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (!!!!! 6287.0979309082): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294778272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (581.97975158691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

147 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

148 (!!!!! 1494.1692352295): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

150 (140.90538024902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

151 (929.11720275879): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294778272 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294778272 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (273.9429473877): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (417.94776916504): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (48.160552978516): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

156 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294778272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294778272 AND published='1' LIMIT 1

157 (110.86463928223): select jos_twitters.link from jos_twitters where cat=10

158 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

159 (59.843063354492): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

161 (540.97175598145): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 13187.170028687): insert into jos_banners_delta values (14615,'2025-06-19 12:26:46','216.73.216.120','view'),(14202,'2025-06-19 12:26:46','216.73.216.120','view'),(14203,'2025-06-19 12:26:46','216.73.216.120','view')

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