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3D Imaging Technique Detects Uterine Contractions

By MedImaging International staff writers
Posted on 25 Mar 2019

Image: EMMI mapping of uterine contractions (Photo courtesy of WUSTL).

A new study suggests that electromyometrial imaging (EMMI) could help identify and prevent preterm labor.

Developed by researchers at Washington University School of Medicine (WUSTL; St. Louis, MO, USA), EMMI combines detailed body surface electrical recording with body-uterus geometry derived from magnetic resonance imaging (MRI) scans. The resulting color-coded, three-dimensional (3D) images and movies display uterine contractions at high spatial and temporal resolutions. By identifying where contractions begin, clinicians can better understand the velocity, direction, and coordination of uterine contractions that contribute to labor.

To show that EMMI can reconstruct uterine electrical activation patterns from electrodes placed on the abdomen, the researchers tested the technique on a sheep model. The contraction patterns measured closely match those recorded with electrodes invasively placed directly on the uterine surface. Modeling experiments showed that EMMI reconstructions are not affected by noise and geometrical deformation, and that the EMMI setup tested on the sheep was suitable for humans as well. The study was published on March 13, 2019, in Science Translational Medicine.

“Our results indicate that EMMI can noninvasively, safely, accurately, robustly, and feasibly image three-dimensional uterine electrical activation during contractions in sheep and suggest that similar results might be obtained in clinical setting,” concluded lead author Yong Wang, PhD, and colleagues. “EMMI might provide an easily accessible method to help doctors during labor and to better understand uterine electrophysiology and pathophysiology.”

“We've got imaging techniques to allow doctors to study another muscular organ – the heart. Without even touching the heart, doctors can determine where each beat comes from, the direction in which it moves, how fast it moves, and much more’” said Kelle Moley, MD, chief scientific officer of the March of Dimes (White Plains, NY, USA), which funded the study. “EMMI is a new way to study the pregnant uterus in a similar fashion, and we hope it will lead to the development of similar types of drugs and treatments to stop contractions that lead to preterm labor.”

Monitoring uterine contractions during labor is critical to ensure good health of the mother and of the baby. In current clinical practice, uterine contractions are monitored via a tocodynamometer or an intrauterine pressure catheter, both of which only provide crude information about contractions.

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71 (437.02125549316): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.982040405273): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (83.92333984375): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (45.7763671875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (47.922134399414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (80.108642578125): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (64.13459777832): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

105 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

106 (90.122222900391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

110 (53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (572.20458984375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (535.01129150391): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (332.83233642578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

115 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

116 (137.8059387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

117 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

118 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

119 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

120 (281.09550476074): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 20943.880081177): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

123 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

124 (418.90144348145): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294777365 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294777365 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 467604.16030884): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (125.88500976562): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (!!!!! 2310.037612915): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (412.94097900391): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=215

136 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=215

137 (473.97613525391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (370.02563476562): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

140 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

141 (!!!!! 13864.040374756): TRUNCATE TABLE jos_trademed_module

142 (106.8115234375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (58.174133300781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294777365 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (523.09036254883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

147 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

148 (!!!!! 1227.1404266357): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

150 (60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

151 (114.91775512695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294777365 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294777365 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (74.148178100586): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

153 (65.088272094727): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=215 or channel_id is null)

154 (108.00361633301): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (81.777572631836): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

156 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294777365 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294777365 AND published='1' LIMIT 1

157 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

158 (34.809112548828): select jos_facebook.link from jos_facebook where cat=10

159 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

160 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

161 (264.88304138184): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1391.8876647949): insert into jos_banners_delta values (14615,'2025-06-19 19:43:36','216.73.216.120','view'),(14202,'2025-06-19 19:43:36','216.73.216.120','view'),(14203,'2025-06-19 19:43:36','216.73.216.120','view')

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