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Protein Clumping May Contribute to HF Development

By MedImaging International staff writers
Posted on 22 May 2018
Image: A PET scan detects clumping proteins in HF (R) (Photo courtesy of Johns Hopkins University).
Image: A PET scan detects clumping proteins in HF (R) (Photo courtesy of Johns Hopkins University).
A new positron emission tomography (PET) study reveals that cardiac preamyloid oligomers (PAOs) form clumps in developing heart failure (HF).

Researchers at the Medical University of Vienna (MedUni; Austria), Johns Hopkins University (JHU; Baltimore, MD, USA), and other institutions conducted a study to see if the mono-phosphorylated protein desmin acts as the seed nucleating PAOs found in human HF. To do so, they used a fluorescent antibody and an amyloid fluorescent stain to visualize and quantify protein clumps in heart tissue biopsies from people with or without HF. They then used a common mouse model of HF to look for desmin clumps. The model involves surgical constriction of the aorta, which raises blood pressure and stress.

After four weeks, the mice develop symptoms of HF, such as an enlarged heart and lung congestion. The researchers used the radioactive dye Amyvid to image the protein clumps by PET. The results showed that desmin amyloid was more than doubled in the HF mice, when using the same antibody and staining techniques used for the human tissue samples. Conversely, when the researchers used epigallocatechin gallate (EGCG) to break up amyloid, the number of protein clumps halved. The study was published on May 11, 2018, in Circulation Research.

“PET imaging of protein clumps may be eventually used in patients to identify structural changes in the heart as the disease progresses, and this information likely holds prognostic value,” said lead author Peter Rainer, MD, PhD, of the Medical University of Graz. “It could be used as a nice measure of the effect of an intervention to halt or reverse disease progression.”

“From a molecular standpoint there’s not a unified, clear mechanism for why the heart goes into failure. But by figuring out this mechanism, we may be able to devise better treatments and diagnostic tools,” said senior author Giulio Agnetti, PhD, of JHU. “I think the next step is to follow up with the proteins that are dynamically modified in response to environment, which places a larger emphasis on lifestyle intervention to help prevent diseases.”

Related Links:
Medical University of Vienna
Johns Hopkins University

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(108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
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		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
51
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
52
(384.09233093262): SELECT name FROM jos_deeppockets WHERE id=294773575 LIMIT 1
53
(226.02081298828): SELECT name FROM jos_deeppockets_archive WHERE id=294773575 LIMIT 1
54
(44.107437133789): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'
55
(56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773575
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
56
(436.78283691406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773575
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
57
(!!!!! 1242.8760528564): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
58
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
59
(98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
60
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
61
(109.91096496582): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 1
62
(444.88906860352): SELECT fid FROM jos_deeppockets WHERE id=294773575 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294773575 AND published='1'  LIMIT 1
63
(43.869018554688): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
64
(56.028366088867): select jos_twitters.link from jos_twitters where cat=10
65
(39.815902709961): select jos_facebook.link from jos_facebook where cat=10
66
(31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10
67
(30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10
68
(42.200088500977): SELECT fid FROM jos_deeppockets WHERE id=294773575 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294773575 AND published='1'  LIMIT 1
69
(33.855438232422): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
70
(354.05158996582): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294773575
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
71
(232.93495178223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
72
(38.14697265625): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
73
(47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1
74
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
75
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
76
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
77
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
78
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
79
(27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
80
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
81
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
82
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
83
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
84
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
85
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
86
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
87
(51.975250244141): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294773575
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
88
(30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89
(33.140182495117): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
90
(65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1
91
(44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1
92
(47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1
93
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
94
(42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1
95
(38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1
96
(55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1
97
(39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
98
(36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
99
(38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
100
(85.115432739258): SELECT show_live FROM jos_com_show_setting LIMIT 1
101
(41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
102
(39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
103
(36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
104
(77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
105
(43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
106
(56.982040405273): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773575
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
107
(46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773575
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
108
(68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
109
(42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
110
(49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294773575
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
111
(620.12672424316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294773575
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
112
(716.9246673584): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
113
(532.86552429199): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
114
(163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
115
(86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
116
(68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
117
(41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
118
(88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
119
(41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
120
(290.87066650391): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121
(!!!!! 30405.99822998): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7
122
(197.17216491699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
123
(163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
124
(!!!!! 1385.9272003174): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773575 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773575 AND type='deeppockets_item' AND published='1'  LIMIT 1
125
(!!!!! 601722.95570374): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
126
(60.796737670898): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
127
(41.961669921875): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
128
(31.948089599609): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
129
(52.928924560547): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
130
(62.942504882812): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
131
(44.107437133789): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
132
(38.862228393555): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
133
(551.93901062012): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294773575
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
134
(430.10711669922): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294773575
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
135
(49.114227294922): SELECT name FROM jos_deeppockets WHERE id=215
136
(32.901763916016): SELECT name FROM jos_deeppockets WHERE id=215
137
(459.90943908691): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
138
(496.14906311035): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
139
(63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
140
(50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
141
(!!!!! 22179.841995239): TRUNCATE TABLE jos_trademed_module
142
(99.18212890625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773575
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
143
(53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773575
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
144
(469.92301940918): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294773575
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145
(106.8115234375): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294773575
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146
(103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
147
(90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
148
(!!!!! 1134.8724365234): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6
149
(101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
150
(87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
151
(83.92333984375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773575 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773575 AND type='deeppockets_item' AND published='1'  LIMIT 1
152
(37.908554077148): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
153
(31.948089599609): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
154
(36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155
(111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
156
(54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773575 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773575 AND published='1'
		LIMIT 1
157
(45.061111450195): select jos_twitters.link from jos_twitters where cat=10
158
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10
159
(31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10
160
(31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10
161
(273.9429473877): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)
162
(!!!!! 3262.0429992676): insert into jos_banners_delta values (14615,'2025-06-20 09:47:12','216.73.216.120','view'),(14202,'2025-06-20 09:47:12','216.73.216.120','view'),(14203,'2025-06-20 09:47:12','216.73.216.120','view')