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Cutting-Edge MRI System Incorporates Hyperpolarized Xenon Imaging for Enhanced Lung Ventilation Assessment

By MedImaging International staff writers
Posted on 09 Jun 2023

Diagnostic lung imaging has witnessed significant advancements, though the lungs still remain one of the most challenging organs for functional imaging. Current diagnostic tools like scintigraphy and CT scans display some of the upper airway structure but have limitations and risks that can hamper repeated diagnostic and therapeutic use for patients and administrators. Current modalities often fall short of visualizing the functional network of over 300 million alveoli, a vital requirement for a better understanding of lung functioning and regional ventilation efficiency. Now, a breakthrough MRI system with integrated Xenon capabilities for enhanced ventilation imaging can provide pulmonologists, surgeons, and respiratory specialists with regional ventilation maps of patients' lungs, aiding in better disease management.

Philips (Amsterdam, The Netherlands) has entered into a collaboration with Polarean Imaging (Durham, NC, USA) to advance the field of hyperpolarized Xenon MRI for patients suffering from respiratory illness. The Philips’ 3T MR 7700 system, equipped with fully integrated multi-nuclei imaging, incorporates Polarean’s XENOVIEW hyperpolarized Xenon contrast agent. XENOVIEW offers pulmonary medicine the opportunity to use the first and only inhaled MRI hyperpolarized contrast agent for unique lung ventilation visualization, without exposing patients to ionizing radiation and related risks. By integrating XENOVIEW with the Philips MR 7700 multi-nuclei MRI scanner, clinicians might be able to observe a patient's lungs in greater detail, while also accurately measuring lung ventilation. For patients with pulmonary disease, this could pave the way for early diagnosis and intervention in serious obstructive lung diseases.

In principle, any atomic element with a significant degree of magnetic polarization can be detected in an MRI scanner. However, the generated MR signal in most cases, like Xenon nuclei, is considerably small compared to the hydrogen nuclei that conventional MRI scans image. The combined expertise of Polarean in hyperpolarization physics and Philips in MR image capture and reconstruction offers a cutting-edge solution for acquiring detailed lung images. By harnessing unique capabilities in hyperpolarization physics, Polarean has devised a practical method of transferring the energy from a circularly polarized laser beam to Xenon nuclei in order to generate hyperpolarized Xenon gas, amplifying its MR signal by 10,000 times. Compared to traditional CT scans that can only image the initial few branches of a patient's airway, Xenon traces the same path as oxygen down to the small airways, visualizing gas distribution. For patients with pulmonary conditions such as COPD, asthma, cystic fibrosis, and bronchopulmonary dysplasia, assessing lung ventilation could enable the detection of early or mild disease and aid therapy monitoring.

“With the MR 7700, we have seamlessly integrated multi-nuclei MR imaging into everyday workflows, making multi-nuclei studies of six different nuclei across all anatomies as simple as dragging and dropping the selected protocol onto an exam card,” said Ruud Zwerink, General Manager of Magnetic Resonance and Digital X-Ray at Philips. “Our collaboration with Polarean to bring hyperpolarized Xenon imaging into the equation is a major breakthrough in improving the diagnosis and management of respiratory disease.”

“Having attained FDA approval for the ﬁrst and only hyperpolarized MR contrast agent with the launch of XENOVIEW at the beginning of 2023, we are excited to enter this agreement with Philips. Its strategic focus on patient and workﬂow centric multi-nuclei imaging in its 3T system provides a uniquely capable platform for clinicians to extend their assessment of lung ventilation,” said Richard Hullihen, CEO of Polarean. “By deploying this novel technology to visualize otherwise unobtainable clinical information using MRI technology, MR imaging can now be expanded into pulmonary medicine, providing a quantitative tool to help clinicians and the patients they treat.”

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61 (!!!!! 7558.1073760986): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

62 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

63 (!!!!! 1021.146774292): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

64 (!!!!! 4193.0675506592): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

65 (!!!!! 1137.0182037354): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

66 (599.14588928223): SELECT fid FROM jos_deeppockets WHERE id=294797497 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294797497 AND published='1' LIMIT 1

67 (359.05838012695): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

68 (!!!!! 1677.9899597168): select jos_twitters.link from jos_twitters where cat=10

69 (61.03515625): select jos_facebook.link from jos_facebook where cat=10

70 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

71 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

72 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE id=294797497 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294797497 AND published='1' LIMIT 1

73 (45.061111450195): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

74 (383.13865661621): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (302.07633972168): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (122.0703125): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (552.89268493652): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (190.01960754395): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (251.05476379395): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (585.07919311523): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (639.91546630859): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (414.84832763672): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (437.97492980957): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (777.00614929199): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (!!!!! 2192.0204162598): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (179.05235290527): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (308.99047851562): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (74.148178100586): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (51.975250244141): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (!!!!! 1027.1072387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (219.10667419434): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (252.00843811035): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (612.02049255371): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 2027.0347595215): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (494.00329589844): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 8970.9758758545): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (431.06079101562): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (396.9669342041): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 5916.8338775635): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1155.1380157471): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (181.91337585449): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (!!!!! 2548.9330291748): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (!!!!! 1229.0477752686): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (!!!!! 1247.8828430176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

109 (800.84800720215): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

110 (!!!!! 1354.9327850342): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797497 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1024.9614715576): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294797497 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1767.1585083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

113 (318.05038452148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

114 (299.21531677246): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797497 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (735.04447937012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294797497 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (777.00614929199): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (626.0871887207): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (231.02760314941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

119 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

120 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

121 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

122 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

123 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

124 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

125 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

126 (558.85314941406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797497 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797497 AND type='deeppockets_item' AND published='1' LIMIT 1

127 (!!!!! 1361357.9273224): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (91.075897216797): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

129 (114.91775512695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

130 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

131 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

133 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

135 (!!!!! 1654.8633575439): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (436.06758117676): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (303.03001403809): SELECT name FROM jos_deeppockets WHERE id=212

138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=212

139 (730.99136352539): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (952.00538635254): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 1587.8677368164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

142 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

143 (!!!!! 1157.0453643799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

144 (364.06517028809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (!!!!! 6639.0037536621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

146 (!!!!! 1080.9898376465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

147 (!!!!! 1884.937286377): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

148 (841.14074707031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

149 (239.13383483887): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

150 (471.11511230469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294797497 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294797497 AND type='deeppockets_item' AND published='1' LIMIT 1

151 (446.08116149902): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

152 (!!!!! 2708.911895752): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (!!!!! 3954.8873901367): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

154 (867.12837219238): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

155 (!!!!! 2861.9766235352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294797497 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294797497 AND published='1' LIMIT 1

156 (51.975250244141): select jos_twitters.link from jos_twitters where cat=10

157 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

158 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

159 (51.021575927734): select jos_linkedin.link from jos_linkedin where cat=10

160 (314.95094299316): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

161 (!!!!! 1422.8820800781): insert into jos_banners_delta values (14615,'2025-04-30 13:28:31','18.225.56.198','view'),(14202,'2025-04-30 13:28:31','18.225.56.198','view'),(14203,'2025-04-30 13:28:31','18.225.56.198','view')

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