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Fujifilm’s AI Technology Predicts Alzheimer’s Disease Progression Using MRI Images

By MedImaging International staff writers
Posted on 22 Apr 2022

In the development of new drugs for Alzheimer’s disease (AD) in recent years, many clinical trials of patients with mild cognitive impairment (MCI) have been conducted to observe amyloid-β presence, which is the major causal substance of AD and begins accumulating prior to onset of AD. However, most clinical trials have not been successful, and it is difficult to prove statistically significant differences. One of the reasons is that the percentage of patients who progress from MCI to AD within two years is less than 20%, and many MCI patients remain unchanged even if they receive placebo. Now, a new artificial intelligence (AI) technology has been shown to predict the progression from MCI to AD with a high accuracy, even with limited learning data.

FUJIFILM Corporation (Tokyo, Japan) has announced positive study results of its new AI Technology for AD Progression Prediction to predict whether patients with MCI will progress to AD within two years. The AI Technology for AD Progression Prediction with an accuracy rate of 88% was developed by Fujifilm based on its advanced image recognition technologies and machine learning expertise. Numerous research has been reported in recent years indicating that the accuracy of image recognition is enhanced by deep learning technology. In addition, accurate predictions require a large dataset of images, although the open database of NA-ADNI, the world’s largest AD research project, only has images of about 1,000 MCI patients. Generally, establishing deep learning technology requires over 10 million images in the research of object recognition. To overcome this limitation, Fujifilm has built AI Technology for AD Progression Prediction, by targeting specific areas inside the brain that are strongly correlated with the progression of AD.

Fujifilm used its advanced image recognition technologies accumulated in the fields of photography and healthcare, and focused on the hippocampus and the anterior temporal lobe, respectively, identified the regions from the three-dimensional MRI brain images that are considered to be strongly correlated with the progression of AD. The company used deep learning to extract detailed atrophy patterns from the described two regions, and calculated them as the image features. AI focused even more on the atrophy patterns in the hippocampus and the amygdala regions which are important regions for AD diagnosis in radiographic image interpretation, and then predicted the progression to AD from those patterns. Fujifilm evaluated the technology’s prediction accuracy by applying the AI Technology for AD Progression Prediction to the databases not only of NA-ADNI but also of J-ADNI that is completely unknown to AI. The findings revealed that the technology’s accuracy in predicting whether patients would progress to AD from MCI was 88% for NA-ADNI and 84% for J-ADNI. AUC, which is an important evaluation index of AI, was 0.95 for NA ADNI and 0.91 for J-ADNI.

The findings verify that the AI Technology for AD Progression Prediction has a high generalizability and can predict which patients would progress from MCI to AD with a high accuracy, even for subjects from different cohorts. Fujifilm will apply the AI technology to the patient stratification, using its prediction results on the clinical trial data, and verify the technology’s usefulness even further. Specifically, it will predict the speed of the patients’ progression to AD, and investigate the possibility of improving the clinical trial’s success rate by excluding the patients who do not progress to AD from the clinical trial, and reducing the gap in the distribution of progression speed between the control group and the treatment group. Moreover, Fujifilm will aim to apply the AI Technology for new clinical trials prospectively. It will also apply the algorithm of the AI Technology to the brain images and clinical data of diverse mental and neural diseases. Fujifilm expects these activities to lead to predicting the prognosis and response to treatment, and can play an important role in promoting personalized medicine.

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61 (!!!!! 7424.1161346436): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

62 (!!!!! 4042.8638458252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

63 (!!!!! 8893.0130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

64 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

65 (!!!!! 10495.901107788): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

66 (595.8080291748): SELECT fid FROM jos_deeppockets WHERE id=294792582 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792582 AND published='1' LIMIT 1

67 (411.03363037109): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

68 (71.048736572266): select jos_twitters.link from jos_twitters where cat=10

69 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

70 (33.855438232422): select jos_google_plus.link from jos_google_plus where cat=10

71 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

72 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294792582 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294792582 AND published='1' LIMIT 1

73 (39.100646972656): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

74 (370.97930908203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (296.11587524414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (960.11161804199): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (!!!!! 7024.0497589111): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (131.84547424316): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (83.92333984375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (420.09353637695): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (74.148178100586): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (!!!!! 2658.1287384033): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (144.00482177734): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (653.02848815918): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (231.02760314941): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (!!!!! 1123.1899261475): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 4037.8570556641): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (288.96331787109): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (408.88786315918): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (!!!!! 2285.9573364258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

109 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

110 (99.18212890625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (643.96858215332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (926.97143554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

113 (192.88063049316): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

114 (675.91667175293): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (777.9598236084): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 1152.0385742188): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (598.90747070312): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (774.86038208008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

119 (227.21290588379): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

120 (737.19024658203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

121 (162.12463378906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

122 (!!!!! 2381.8016052246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

123 (311.13624572754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

124 (315.90461730957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 42517.900466919): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (432.01446533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

127 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

128 (908.85162353516): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792582 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792582 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 1898486.8526459): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (79.154968261719): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (144.95849609375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (103.95050048828): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (73.19450378418): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (63.180923461914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (555.03845214844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (435.11390686035): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (221.01402282715): SELECT name FROM jos_deeppockets WHERE id=212

140 (56.982040405273): SELECT name FROM jos_deeppockets WHERE id=212

141 (504.0168762207): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (472.06878662109): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

144 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

145 (!!!!! 9623.0506896973): TRUNCATE TABLE jos_trademed_module

146 (!!!!! 3576.9939422607): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (136.13700866699): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294792582 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (566.95938110352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

151 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

152 (!!!!! 1287.9371643066): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

154 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

155 (66.041946411133): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294792582 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294792582 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (36.954879760742): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

158 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (!!!!! 3946.06590271): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

160 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294792582 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294792582 AND published='1' LIMIT 1

161 (245.09429931641): select jos_twitters.link from jos_twitters where cat=10

162 (79.870223999023): select jos_facebook.link from jos_facebook where cat=10

163 (80.82389831543): select jos_google_plus.link from jos_google_plus where cat=10

164 (66.995620727539): select jos_linkedin.link from jos_linkedin where cat=10

165 (399.82795715332): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 8594.0361022949): insert into jos_banners_delta values (14615,'2025-05-02 06:20:50','3.15.31.125','view'),(14202,'2025-05-02 06:20:50','3.15.31.125','view'),(14203,'2025-05-02 06:20:50','3.15.31.125','view')

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