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MRI-Guided Radiotherapy for Prostate Cancer Cuts Treatment Side Effects by 50%

By MedImaging International staff writers
Posted on 17 Feb 2022

An interim analysis of an ongoing Phase III study indicates that using magnetic resonance imaging (MRI) to guide precisely-focused high-dose radiation treatment for prostate cancer reduced side effects associated with the treatment.

The study is being conducted by investigators from the UCLA Jonsson Comprehensive Cancer Center (Los Angeles, CA, USA). Advanced radiation techniques like high-dose stereotactic body radiotherapy (SBRT) offer the opportunity to deliver high radiation doses to tumors while sparing surrounding tissues. Clinicians often use computed tomography (CT) to help make sure the dose is delivered with precision. MRI offers several theoretical advantages over CT to guide SBRT for prostate cancer, including the ability to aggressively reduce planning margins needed for radiation due to enhanced imaging capabilities.

For the current study, men undergoing SBRT for localized prostate cancer were randomly assigned to either CT-guidance or MRI-guidance. Investigators planned to compare the groups to see how often men suffered serious side effects, called toxicities, over the next 90 days after treatment. The investigators believed they would need to enroll 300 patients to be able to detect a benefit to MRI-guidance, but had planned to analyze the data after 100 patients were treated in order to see if this hypothesis were true or if fewer patients might need to be enrolled.

In this analysis of the first 100 patients treated, the investigators found that men undergoing MRI-guidance were less than half as likely to experience Grade 2 genitourinary (GU) toxicity (22% vs. 47%), like frequent urination, burning sensation while urinating, bloody urine, or urinary incontinence. And while a significant proportion of men who had CT-guidance suffered gastrointestinal (GI) toxicities, such as diarrhea, discharge, or rectal/abdominal pain to abdominal distention or obstruction, none of them men undergoing MRI-guidance did so (14% vs. 0%).

“MRI-guidance offers a statistically significant reduction in acute grade GU as well as GI toxicity for prostate SBRT,” said Dr. Amar Kishan, vice chair of clinical and translational research in the Departments of Radiation Oncology and Urology at UCLA Health Jonsson Comprehensive Cancer Center. “Because of the significant effect size we saw, we were able to cut our projected sample size in half. Thus, we finished enrolling on our trial in October 2021. Our final results are expected later this year, but we are extremely optimistic by what we’re seeing, and hope this technology will soon begin to offer men undergoing radiotherapy for prostate cancer better outcomes.”

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66 (526.90505981445): SELECT fid FROM jos_deeppockets WHERE id=294791640 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791640 AND published='1' LIMIT 1

67 (328.06396484375): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

68 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

69 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

70 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

71 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

72 (35.04753112793): SELECT fid FROM jos_deeppockets WHERE id=294791640 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791640 AND published='1' LIMIT 1

73 (30.040740966797): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

74 (255.10787963867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (248.90899658203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (53.882598876953): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

109 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

110 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (47.206878662109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

113 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

114 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (471.11511230469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (542.16384887695): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (386.95335388184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

119 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

120 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

121 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

122 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

123 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

124 (236.98806762695): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 17559.051513672): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

127 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

128 (493.04962158203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791640 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791640 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 432934.99946594): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (89.168548583984): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (545.97854614258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (422.00088500977): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (338.07754516602): SELECT name FROM jos_deeppockets WHERE id=212

140 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=212

141 (442.0280456543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (415.08674621582): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

144 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

145 (!!!!! 9717.2260284424): TRUNCATE TABLE jos_trademed_module

146 (110.14938354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791640 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (744.81964111328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (88.214874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

151 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

152 (!!!!! 1528.9783477783): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

154 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

155 (58.174133300781): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791640 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791640 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (44.822692871094): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

158 (44.822692871094): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

160 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791640 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791640 AND published='1' LIMIT 1

161 (48.160552978516): select jos_twitters.link from jos_twitters where cat=10

162 (37.193298339844): select jos_facebook.link from jos_facebook where cat=10

163 (39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10

164 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

165 (293.01643371582): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1461.0290527344): insert into jos_banners_delta values (14615,'2025-05-01 15:37:50','18.222.226.15','view'),(14202,'2025-05-01 15:37:50','18.222.226.15','view'),(14203,'2025-05-01 15:37:50','18.222.226.15','view')

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