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New MRI-Guided Therapy Navigates Magnetic Seed Through Brain to Heat and Destroy Tumors

By MedImaging International staff writers
Posted on 03 Feb 2022

Scientists have developed a novel cancer therapy that uses an MRI scanner to guide a magnetic seed through the brain to heat and destroy tumors.

The therapy, demonstrated by scientists at University College London (London, UK), in mice, is called “minimally invasive image-guided ablation” or MINIMA and comprises a ferromagnetic thermoseed navigated to a tumor using magnetic propulsion gradients generated by an MRI scanner, before being remotely heated to kill nearby cancer cells. The researchers say their findings establish ‘proof-of-concept’ for precise and effective treatment of hard-to-reach glioblastoma, along with other cancers such as prostate, that could benefit from less invasive therapies.

In the study, the UCL team demonstrated the three key components of MINIMA to a high level of accuracy: precise seed imaging; navigation through brain tissue using a tailored MRI system, tracked to within 0.3 mm accuracy; and eradicating the tumor by heating it in a mouse model. Ferromagnetic thermoseeds are spherical in shape, 2 mm in size and are made of a metal alloy; they are implanted superficially into tissue before being navigated to the cancer. MRI scanners are readily available in hospitals around the world and are pivotal in the diagnosis of diseases such as cancer. The work at UCL shows that MINIMA has the potential to elevate an MRI scanner from a diagnostic device to a therapeutic platform.

“MINIMA is a new MRI-guided therapy that has the potential to avoid traditional side effects by precisely treating the tumor without harming healthy tissues,” said senior author, Professor Mark Lythgoe (UCL Centre for Advanced Biomedical Imaging). “Because the heating seed is magnetic, the magnetic fields in the MRI scanner can be used to remotely steer the seed through tissue to the tumor. Once at the tumor, the seed can then be heated, destroying the cancer cells, while causing limited damage to surrounding healthy tissues.”

“Using an MRI scanner to deliver a therapy in this way allows the therapeutic seed and the tumor to be imaged throughout the procedure, ensuring the treatment is delivered with precision and without having to perform open surgery,” added lead author, Rebecca Baker, (UCL Centre for Advanced Biomedical Imaging). “This could be beneficial to patients by reducing recovery times and minimizing the chance of side effects.”

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62 (420.09353637695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

63 (!!!!! 1614.0937805176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

64 (86.784362792969): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

65 (141.85905456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

66 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

67 (136.8522644043): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

68 (648.02169799805): SELECT fid FROM jos_deeppockets WHERE id=294791473 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791473 AND published='1' LIMIT 1

69 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (152.1110534668): select jos_twitters.link from jos_twitters where cat=10

71 (66.041946411133): select jos_facebook.link from jos_facebook where cat=10

72 (45.061111450195): select jos_google_plus.link from jos_google_plus where cat=10

73 (38.862228393555): select jos_linkedin.link from jos_linkedin where cat=10

74 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE id=294791473 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791473 AND published='1' LIMIT 1

75 (44.822692871094): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

76 (497.10273742676): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (369.07196044922): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

78 (58.889389038086): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

79 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (71.048736572266): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (51.021575927734): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

95 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

96 (75.101852416992): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

110 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

111 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

112 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (64.13459777832): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

115 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

116 (521.89826965332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (509.02366638184): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791467 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (351.90582275391): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791467 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

120 (634.90867614746): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (348.09112548828): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

122 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

123 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

124 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

125 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

126 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

127 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

128 (249.14741516113): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

129 (!!!!! 17355.918884277): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

130 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

131 (47.206878662109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

132 (391.96014404297): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791473 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791473 AND type='deeppockets_item' AND published='1' LIMIT 1

133 (!!!!! 468760.01358032): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (76.055526733398): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

135 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

136 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

137 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

138 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

139 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

140 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

141 (492.09594726562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (391.96014404297): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=212

144 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

145 (475.88348388672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

146 (367.87986755371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

147 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

148 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

149 (!!!!! 8170.1278686523): TRUNCATE TABLE jos_trademed_module

150 (97.990036010742): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

151 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791473 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

152 (946.044921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

153 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

154 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

155 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

156 (!!!!! 1071.9299316406): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

157 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

158 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

159 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791473 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791473 AND type='deeppockets_item' AND published='1' LIMIT 1

160 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

161 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

162 (34.809112548828): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

163 (352.85949707031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

164 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791473 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791473 AND published='1' LIMIT 1

165 (37.908554077148): select jos_twitters.link from jos_twitters where cat=10

166 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

167 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

168 (54.121017456055): select jos_linkedin.link from jos_linkedin where cat=10

169 (288.00964355469): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

170 (!!!!! 1203.0601501465): insert into jos_banners_delta values (14615,'2025-05-01 12:42:47','18.191.144.80','view'),(14202,'2025-05-01 12:42:47','18.191.144.80','view'),(14203,'2025-05-01 12:42:47','18.191.144.80','view')

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