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Combining Artificial Intelligence with 30 Second MRI Scan Predicts Health of Placenta

By MedImaging International staff writers
Posted on 27 Aug 2021

Researchers have proposed a machine learning method that predicts the health of the placenta from a 30 second MRI scan.

The algorithm developed by researchers from the School of Biomedical Engineering & Imaging Sciences at King's College London (London, UK) models the normal distribution of placental tissue properties which can be used to screen for deviations from normal placental ageing and signs of pregnancy complications. The researchers use this method to detect pre-eclampsia, a condition that affects 4 to 7% of pregnancies with significant mortality and morbidity for both mother and child. The 30 second scan together with the automatic pipeline can easily be included in any fetal MRI examination and allows obtaining additional, previously not available information leading to better treatment and information.

According to the researchers, detecting pre-eclampsia is essential to achieve optimal monitoring and thus the best possible outcome. The method is most sensitive early in the second half of pregnancy which is also the typical time of onset of pre-eclampsia. This allows early detection and monitoring of this complication. The machine learning pipeline automates manual segmentation of the placenta, which can take up to one hour per case, and uses data-driven models to define normal intervals of tissue properties within the placenta. This new technique is fast and removes any laborious steps. At the same time, it uses human-inspectable and interpretable intermediate representations of the data, keeping clinicians in the loop and allowing optional corrections and alleviating issues related to black-box algorithms for clinical decision making. Also, incorporating the uncertainty associated with the data in the model improves the method’s ability to assign lower health scores to high-risk placentas (AUC ROC) from 69% to 95%.

“This method develops a clinical marker and automates its extraction which would otherwise be prohibitively time-consuming in clinical practice,” said Dr. Maximilian Pietsch, Research Associate, School of Biomedical Engineering & Imaging Sciences. “The validation on an independent clinical cohort with MRI data acquired at a different field strength shows that it can be a valuable clinical tool.”

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67 (587.94021606445): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

68 (!!!!! 1564.0258789062): select jos_twitters.link from jos_twitters where cat=10

69 (524.04403686523): select jos_facebook.link from jos_facebook where cat=10

70 (826.83563232422): select jos_google_plus.link from jos_google_plus where cat=10

71 (!!!!! 3239.8700714111): select jos_linkedin.link from jos_linkedin where cat=10

72 (!!!!! 1084.0892791748): SELECT fid FROM jos_deeppockets WHERE id=294789445 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294789445 AND published='1' LIMIT 1

73 (!!!!! 4397.8691101074): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

74 (720.97778320312): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (835.18028259277): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (!!!!! 2290.0104522705): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (!!!!! 1295.804977417): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (118.01719665527): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (507.83157348633): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (!!!!! 1883.9836120605): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (888.10920715332): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (230.07392883301): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (886.91711425781): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (550.98533630371): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 3285.1696014404): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (159.02519226074): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (87.02278137207): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (876.90353393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

109 (120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

110 (670.9098815918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 2327.9190063477): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (546.93222045898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

113 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

114 (798.22540283203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (485.18180847168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 1163.9595031738): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (891.92390441895): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (406.02684020996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

119 (343.79959106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

120 (736.95182800293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

121 (316.85829162598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

122 (482.08236694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

123 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

124 (517.84515380859): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 82360.029220581): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

127 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

128 (963.92631530762): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789445 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789445 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 643562.07847595): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (121.11663818359): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (637.05444335938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (388.86070251465): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=212

140 (30.994415283203): SELECT name FROM jos_deeppockets WHERE id=212

141 (504.97055053711): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (442.0280456543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

144 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

145 (!!!!! 9938.9553070068): TRUNCATE TABLE jos_trademed_module

146 (117.06352233887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294789445 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (578.16505432129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

151 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

152 (!!!!! 1204.0138244629): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

154 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

155 (60.796737670898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294789445 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294789445 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (85.115432739258): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

158 (56.982040405273): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

160 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294789445 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294789445 AND published='1' LIMIT 1

161 (45.061111450195): select jos_twitters.link from jos_twitters where cat=10

162 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

163 (35.04753112793): select jos_google_plus.link from jos_google_plus where cat=10

164 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

165 (316.85829162598): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1770.01953125): insert into jos_banners_delta values (14615,'2025-05-01 21:01:38','3.128.153.31','view'),(14202,'2025-05-01 21:01:38','3.128.153.31','view'),(14203,'2025-05-01 21:01:38','3.128.153.31','view')

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