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Hyperscan Proton Therapy System Offers Pinpoint Accuracy

By MedImaging International staff writers
Posted on 14 May 2018
An innovative Proton Therapy System improves on existing scanning capabilities and enables clinicians to deliver conformal fields faster and with more precision than in the past.

The Mevion Medical Systems (Mevion; Littleton, MA, USA) S250i Proton Therapy System with Hyperscan pencil beam scanning (PBS) shapes the delivered radiation dose by precisely targeting tumors with sub-atomic particles. To improve accuracy and speed, a robotically controlled adaptive aperture proton multi-leaf collimator (pMLC) is used, which trims the edges of the beam to achieve sharp lateral dose gradients. This capability can deliver up to a three times sharper drop off in radiation at the delivery field edge, sparing healthy tissue and limiting unnecessary radiation to sensitive locations.

By reducing delivery times to less than five seconds, errors resulting from target tumor shifting under normal organ motion, such as breathing, can be reduced. Other features of the S250i include a gantry mounted superconducting synchrocyclotron, a six degree-of-freedom treatment couch, and advanced in-room image guidance that creates a three-dimensional (3D) representation of the tumor and relays the information to the proton therapy device. The computerized tomography (CT) based imager can also be used to modify treatment in response to changes in the patient’s anatomy, such as tumor shrinkage.

“Proton therapy is an advanced form of radiation that can destroy cancer cells. A machine called a cyclotron speeds up protons to two thirds the speed of light and they become highly charged,” said radiation oncologist Peter Ahn, MD, of MedStar Georgetown (Washington DC, USA), which inaugurated the first system worldwide in April 2018. “Because we can more tightly control the protons than we are able with traditional radiation, proton therapy can be given without damaging critical tissues and structures near the tumor because the beam conforms precisely to the tumor’s size and shape.”

“Delivering sharp field edges has been a real challenge for PBS, especially in shallow fields. In intracranial procedures, where critical structures are in close proximity to tumors at shallow depths, having the sharpest lateral penumbra is essential,” said Skip Rosenthal, VP of clinical education at Mevion. “The sharp penumbras of the adaptive aperture system have substantial benefits for these patients. In addition, the enhanced speed of Hyperscan PBS could enable greater confidence in treating thoracic tumors.”

Proton therapy is a precise form of radiotherapy (RT) that uses charged particles instead of x-rays. It can be a more effective form of treatment than conventional RT as it directs the beam more precisely, with minimal damage to surrounding tissue. Evidence is growing that protons can be effective in treating a number of cancers, in particular children and young people with brain tumors, for whom it appears to produce fewer side effects such as secondary cancers, growth deformity, hearing loss, and learning difficulties.

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			LIMIT 1
48
(29.087066650391): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294773485

			LIMIT 1
49
(28.848648071289): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294773485

			LIMIT 1
50
(30.040740966797): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294773485

			LIMIT 1
51
(437.02125549316): select journal.name,journal.id,dpcat.livesite,journal.code
				from jos_dp_categories dpcat
				join jos_journal journal
				on journal.id=dpcat.journalid
				where dpcat.id=10
52
(!!!!! 6579.8759460449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
53
(120.87821960449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
54
(72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
55
(43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
56
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
57
(41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
58
(136.8522644043): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
59
(48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
60
(258.9225769043): SELECT name FROM jos_deeppockets WHERE id=294773485 LIMIT 1
61
(190.97328186035): SELECT name FROM jos_deeppockets_archive WHERE id=294773485 LIMIT 1
62
(45.7763671875): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'
63
(55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773485
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
64
(396.0132598877): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773485
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
65
(!!!!! 1003.0269622803): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
66
(!!!!! 7332.0865631104): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
67
(!!!!! 1332.9982757568): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
68
(594.8543548584): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
69
(!!!!! 2375.8411407471): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 1
70
(!!!!! 2105.2360534668): SELECT fid FROM jos_deeppockets WHERE id=294773485 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294773485 AND published='1'  LIMIT 1
71
(!!!!! 1219.0341949463): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
72
(!!!!! 2302.885055542): select jos_twitters.link from jos_twitters where cat=10
73
(!!!!! 2305.9844970703): select jos_facebook.link from jos_facebook where cat=10
74
(102.99682617188): select jos_google_plus.link from jos_google_plus where cat=10
75
(27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10
76
(111.10305786133): SELECT fid FROM jos_deeppockets WHERE id=294773485 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294773485 AND published='1'  LIMIT 1
77
(576.97296142578): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=215
                    ORDER BY `ordering`
78
(463.00888061523): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294773485
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
79
(435.11390686035): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773485 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
80
(!!!!! 1496.0765838623): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
81
(509.02366638184): SELECT show_live FROM jos_com_show_setting LIMIT 1
82
(388.86070251465): SELECT show_live FROM jos_com_show_setting LIMIT 1
83
(477.07557678223): SELECT show_live FROM jos_com_show_setting LIMIT 1
84
(344.03800964355): SELECT show_live FROM jos_com_show_setting LIMIT 1
85
(375.98609924316): SELECT show_live FROM jos_com_show_setting LIMIT 1
86
(347.13745117188): SELECT show_live FROM jos_com_show_setting LIMIT 1
87
(382.90023803711): SELECT show_live FROM jos_com_show_setting LIMIT 1
88
(308.03680419922): SELECT show_live FROM jos_com_show_setting LIMIT 1
89
(531.91184997559): SELECT show_live FROM jos_com_show_setting LIMIT 1
90
(104.90417480469): SELECT show_live FROM jos_com_show_setting LIMIT 1
91
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
92
(910.04371643066): SELECT show_live FROM jos_com_show_setting LIMIT 1
93
(73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1
94
(136.8522644043): SELECT show_live FROM jos_com_show_setting LIMIT 1
95
(44.107437133789): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294773485
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
96
(215.05355834961): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773485 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
97
(164.98565673828): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
98
(49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1
99
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
100
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
101
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
102
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
103
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
104
(32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1
105
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
106
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
107
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
108
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
109
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
110
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
111
(25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
112
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
113
(40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
114
(50.783157348633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773485
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
115
(46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773485
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
116
(250.81634521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
117
(!!!!! 3249.8836517334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
118
(51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294773485
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
119
(357.15103149414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294773485
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
120
(574.82719421387): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
121
(333.07075500488): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
122
(72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
123
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
124
(60.796737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
125
(37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
126
(87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
127
(36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
128
(152.8263092041): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
129
(!!!!! 61105.012893677): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7
130
(!!!!! 4586.935043335): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
131
(66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
132
(634.90867614746): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773485 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773485 AND type='deeppockets_item' AND published='1'  LIMIT 1
133
(!!!!! 860972.1660614): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
134
(158.78677368164): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
135
(161.88621520996): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
136
(181.19812011719): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
137
(160.93254089355): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
138
(212.9077911377): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
139
(131.13021850586): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
140
(129.93812561035): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
141
(!!!!! 2388.9541625977): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294773485
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
142
(967.02575683594): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294773485
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
143
(159.02519226074): SELECT name FROM jos_deeppockets WHERE id=215
144
(72.956085205078): SELECT name FROM jos_deeppockets WHERE id=215
145
(433.20655822754): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
146
(346.18377685547): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))215((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
147
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
148
(41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
149
(!!!!! 8872.9858398438): TRUNCATE TABLE jos_trademed_module
150
(110.14938354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294773485
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
151
(61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294773485
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
152
(712.15629577637): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294773485
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
153
(555.99212646484): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294773485
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
154
(51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
155
(41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
156
(!!!!! 1921.1769104004): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6
157
(152.8263092041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
158
(217.19932556152): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
159
(93.936920166016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294773485 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294773485 AND type='deeppockets_item' AND published='1'  LIMIT 1
160
(113.01040649414): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
161
(265.83671569824): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=215 or channel_id is null)
162
(90.837478637695): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
163
(380.03921508789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
164
(133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294773485 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294773485 AND published='1'
		LIMIT 1
165
(42.915344238281): select jos_twitters.link from jos_twitters where cat=10
166
(30.040740966797): select jos_facebook.link from jos_facebook where cat=10
167
(29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10
168
(27.179718017578): select jos_linkedin.link from jos_linkedin where cat=10
169
(313.04359436035): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)
170
(!!!!! 1147.0317840576): insert into jos_banners_delta values (14615,'2025-04-30 18:58:49','3.15.7.241','view'),(14202,'2025-04-30 18:58:49','3.15.7.241','view'),(14203,'2025-04-30 18:58:49','3.15.7.241','view')