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Digital PET/CT Technology to Provide Improved Image Quality

By MedImaging International staff writers
Posted on 05 Jan 2016

A new generation of PET/CT scanners could lead to improved patient care according to a study presented at the annual Radiological Society of North America (RSNA 2015) meeting in Chicago (IL, USA).

The new systems Positron Emission Tomography/Computed Tomography (PET/CT) technology uses solid-state components, and all-digital data, and provides a dramatic reduction in the tracer dose for clinical PET imaging. Other advantages of the new technology include improved accuracy and visual/quantitative quality, and improved reproducibility of measurements for PET imaging in clinical oncology.

In the Phase 1 study, blinded readers compared images made using current generation photomultiplier tubes with images scanned using Royal Philips Healthcare (Amsterdam, The Netherlands) Vereos 64 TF scanners in which the tubes were replaced by a solid-state digital photon counting chip. The readers reported higher confidence in the detection and delineation of lesions on scans of 30 patients with various malignant tumors, using the new scanners.

The new end-to-end digital solid state scanners dramatically improve image reconstruction capabilities compared to existing scanners, and temporal resolution is improved from 500 picoseconds to 325 picoseconds. Very high resolution reconstruction is possible with new scanners, without compromising image quality, and a slice thickness as thin as 1–2 mm. According to the study, the new scanners can use half the radiation dose of current technology, without any impact on quality and detectability.

Dr. Knopp, director, Wright Center for Innovation and Biomedical Imaging, Ohio State University "The system and the technology have performed remarkably well. It allows us to visualize with a higher definition and higher reconstruction maintenance, which can translate into better lesion detectability and quantitative accuracy. Also, confidence of lesion detectability was rated significantly higher on the digital PET when evaluating lesions of less than 15 mm. This research demonstrates that the new generation of PET scanners can be used as a better clinical tool or biomarker, especially for today's targeted therapeutics. The images look crisper and more precise and provide a truer metabolic coefficient ratio. This technology can redefine our clinical work, especially with some of the exciting new tracer doses on the horizon."

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67 (335.9317779541): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

68 (45.061111450195): select jos_twitters.link from jos_twitters where cat=10

69 (27.894973754883): select jos_facebook.link from jos_facebook where cat=10

70 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

71 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

72 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294762106 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294762106 AND published='1' LIMIT 1

73 (34.093856811523): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

74 (240.80276489258): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

75 (204.08630371094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (38.14697265625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

77 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.153762817383): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

92 (33.855438232422): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

94 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

109 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

110 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

113 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

114 (65.803527832031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (613.21258544922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (787.01972961426): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (510.21575927734): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (159.97886657715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

119 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

120 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

122 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

123 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

124 (316.14303588867): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

125 (!!!!! 30033.826828003): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

126 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

127 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

128 (514.03045654297): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762106 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762106 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 402696.13265991): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (99.897384643555): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

132 (28.848648071289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

133 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

134 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

135 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

136 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

137 (495.19538879395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (472.06878662109): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

139 (264.88304138184): SELECT name FROM jos_deeppockets WHERE id=213

140 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=213

141 (452.99530029297): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (348.09112548828): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

143 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

144 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

145 (!!!!! 8126.974105835): TRUNCATE TABLE jos_trademed_module

146 (128.03077697754): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762106 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

148 (!!!!! 1078.1288146973): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

150 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

151 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

152 (!!!!! 1204.9674987793): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

153 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

154 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

155 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762106 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762106 AND type='deeppockets_item' AND published='1' LIMIT 1

156 (38.14697265625): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

157 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

158 (41.007995605469): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

159 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

160 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762106 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762106 AND published='1' LIMIT 1

161 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

162 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

163 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

164 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

165 (297.78480529785): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

166 (!!!!! 1204.9674987793): insert into jos_banners_delta values (14615,'2025-05-02 04:04:25','3.144.193.1','view'),(14202,'2025-05-02 04:04:25','3.144.193.1','view'),(14203,'2025-05-02 04:04:25','3.144.193.1','view')

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