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Cancer Pain Eased by MR-Guided, Focused Ultrasound Ablation Therapy

By MedImaging International staff writers
Posted on 18 Jun 2013
Patients with cancer that has metastasized to their bones are frequently treated with radiation therapy to reduce pain. But if that treatment does not work, or cannot be used again, a second, effective alternative, called magnetic resonance image-guided focused ultrasound (MRIgFU) ablation therapy, now exists.

The findings on the new therapy were presented in June 2013 at the annual meeting of the American Society of Clinical Oncology (ASCO), held in Chicago (IL, USA). Mark Hurwitz, MD, director of thermal oncology for the department of radiation oncology at Thomas Jefferson University (Philadelphia, PA, USA) and Hospital, reported that the treatment, MRIgFU ablation therapy, considerably decreases pain in 67% of patients who received the treatment. The device, known as ExAblate, uses many small ultrasound beams designed to converge on a tumor within bone, heat it, and destroy it.

“Pain is a common, often debilitating symptom of the spread of cancer to bones. We are pleased to now have a second therapy that can improve a patient’s enjoyment of life,” said Dr. Hurwitz, who led the clinical trial. A number of tumors metastasize to bones, and a substantial amount of patients live for years with these metastases, which can have a profound impact on a patient's quality of life, he added.

The findings of the trial led to approval of ExAblate last October by the US Food and Drug Administration (FDA) as second-line therapy for palliation of painful metastatic bone tumors. The first-line therapy is typically radiotherapy.

“The response to ExAblate was as good as radiotherapy, which was notable because it is very unusual to see a second-line treatment with a response rate that is as high as first-line therapy,” Dr. Hurwitz stated. He added that use of ExAblate offers several advantages compared to other ablative therapies. “It is noninvasive and provides more detailed anatomic information so that we can visualize the complete beam path to make sure that critical structures such as vessels and nerves are not in the way,” Dr. Hurwitz stated. “We are also able to monitor the temperature in the tumor as well as in nearby normal tissues so that we do not inadvertently heat normal organs and tissues.”

ExAblate has also been approved for treatment of uterine fibroids. The study led by Dr. Hurwitz is a multicenter, randomized, and placebo-controlled phase three clinical trial. The 142 patients enrolled could either not undergo, or had not responded to, radiation treatment. Three months after ExAblate therapy, 67% of treated patients reported significant improvement in pain, compared to 21% in the placebo arm. They typically rated their pain as “much improved” or “very much improved,” Dr. Hurwitz said.

A quality of life assessment in addition measured significant improvement. “The treatment is given just once, and a response occurs within days,” Dr. Hurwitz noted. “There are a lot of patients who could potentially benefit from MR guided focused ultrasound.”

The clinical trial was sponsored by Insightec, Ltd. (Tirat Carmel, Israel), who developed the ExAblate technology.

Related Links:

Thomas Jefferson University
Insightec


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92 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (111.81831359863): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
105 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
106 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (137.8059387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
109 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
110 (80.108642578125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (699.04327392578): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (699.99694824219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (622.98774719238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (211.95411682129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
115 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
116 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
117 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
118 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
119 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
120 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
121 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
122 (446.08116149902): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 22486.925125122): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (805.13954162598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746821 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746821 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 9137.8688812256): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (224.11346435547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (87.976455688477): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (250.10108947754): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (37.193298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (524.04403686523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (349.99847412109): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (221.01402282715): SELECT name FROM jos_deeppockets WHERE id=214
138 (51.021575927734): SELECT name FROM jos_deeppockets WHERE id=214
139 (621.79565429688): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (658.98895263672): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))214((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
142 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
143 (!!!!! 11435.985565186): TRUNCATE TABLE jos_trademed_module
144 (132.08389282227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746821 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (733.85238647461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
149 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
150 (!!!!! 1668.9300537109): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
152 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
153 (58.889389038086): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746821 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746821 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (49.114227294922): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=214 or channel_id is null)
156 (48.87580871582): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
158 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746821 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746821 AND published='1' LIMIT 1
159 (69.856643676758): select jos_twitters.link from jos_twitters where cat=10
160 (43.153762817383): select jos_facebook.link from jos_facebook where cat=10
161 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10
162 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10