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Molecular Breast Imaging a Useful Adjunct to Mammography

By MedImaging International staff writers
Posted on 29 May 2013

Molecular breast imaging (MBI), also known as breast-specific gamma imaging (BSGI), is a comparatively new form of breast cancer detection performed by injecting the patient in the arm with a specialized tracer and then obtaining images of the tracer distribution using detectors. The imaging procedure is similar to that of mammography, but with significantly less compression, and each image takes between 5–10 minutes to obtain.

Earlier research has established that it can detect tumors overlooked by mammography, especially in patients with dense breast tissue; however, this new research, published in the February 2013 issue of the European Journal of Nuclear Medicine and Molecular Imaging, is the largest analysis conducted to date.

Dr. Yu Sun, from the department of breast surgery, Guangxi Cancer Hospital, Affiliated Cancer Hospital of Guangxi Medical University (Nanning City, Guangxi, People’s Republic of China) and his research team evaluated hundreds of peer-reviewed articles published on this modality to determine the validity of the scientific methodology used in each study. Nineteen articles containing 3,093 patients met their precise criteria for inclusion. Their meta-analysis determined that MBI detected 95% of the tumors overall and that it was particularly useful in: cancers smaller than 1 cm; an early stage cancer called ductal carcinoma in-situ (DCIS); and a type of cancer called lobular carcinoma, which is difficult to detect with mammography with sensitivities of 84%, 88%, and 93%, respectively.

The smallest malignancy identified by MBI was 1 mm and it was able to detect breast cancer in four of every 100 women who had a negative mammogram. The authors also noted that MBI was as sensitive as breast MRI in the detection of breast cancer, but provided higher specificity (80%) meaning fewer positive findings in women without disease. Moreover, the MBI procedure can be performed for approximately one-third the cost of breast magnetic resonance imaging (MRI) and is useful for patients who cannot have an MRI study. Their findings also suggested that similar to breast MRI, MBI can detect additional tumors in six of every 100 women who have only one cancer seen by mammography and ultrasound and that it may be useful to help monitor the response of tumors to chemotherapy in patients who are receiving their chemotherapy before breast surgery.

Although the MBI procedure does expose the patient to some radiation, the radiation dose patients receive is similar to that of other diagnostic imaging studies routinely used in medical imaging and there are several researchers looking to reduce the dose even further in to expand its use into breast cancer screening.

The authors concluded, “Current evidence suggests that BSGI is an extremely useful adjunct to mammography for its ability to identify breast cancer with a high diagnostic performance.”

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65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

67 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

68 (87.02278137207): SELECT fid FROM jos_deeppockets WHERE id=294746516 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746516 AND published='1' LIMIT 1

69 (36.954879760742): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=213 ORDER BY `ordering`

70 (370.02563476562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (234.84230041504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.140182495117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (102.04315185547): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

105 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

106 (75.817108154297): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

109 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

110 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (577.92663574219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (666.14151000977): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (551.93901062012): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

115 (116.10984802246): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

116 (73.19450378418): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

117 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

118 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

120 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

121 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

122 (501.87110900879): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 24322.032928467): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (609.15946960449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746516 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746516 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8980.0357818604): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (129.93812561035): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (319.00405883789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (608.20579528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (476.83715820312): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (230.07392883301): SELECT name FROM jos_deeppockets WHERE id=213

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=213

139 (864.98260498047): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (653.02848815918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))213((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

142 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

143 (!!!!! 8953.8097381592): TRUNCATE TABLE jos_trademed_module

144 (118.97087097168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746516 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1155.8532714844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

149 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

150 (!!!!! 1564.0258789062): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

152 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

153 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746516 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746516 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (48.87580871582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

155 (42.200088500977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=213 or channel_id is null)

156 (42.915344238281): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

158 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746516 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746516 AND published='1' LIMIT 1

159 (40.054321289062): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

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